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Organofluorine compounds in biology and medicine /
This book covers topics on biochemically relevant organofluorine compounds and their synthesis and biochemical pathways. Organofluorine compounds have renewed interest in pharmaceutical industry, and therefore a concise book on this topic is highly relevant to the scientific community involved in th...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam, Netherlands :
Elsevier,
[2015]
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Organofluorine Compounds in Biology and Medicine; Copyright; To My Parents and Teachers; Contents; Short Biography; Preface; Importance of this Book; Chapter 1
- General Aspects of Organofluorine Compounds; 1. INTRODUCTION; 2. C-F BOND STRENGTHS; 3. EFFECT OF THE NEIGHBORING C-F BONDS ON THE C-H BOND DISSOCIATION ENERGIES; 4. EFFECT OF FLUORINE ON THE ACIDITY AND BASICITY; 5. EFFECT OF FLUORINE ON THE METABOLIC STABILITY; 6. EFFECT OF FLUORINE ON THE BIOAVAILABILITY; 7. POSITRON EMISSION TOMOGRAPHY TRACERS; 8. 19F NMR SPECTROSCOPIC TECHNIQUES FOR PROBING BIOCHEMICAL MECHANISMS.
- 9. SUMMARY AND OUTLOOKREFERENCES; Chapter 2
- Fluorinated Compounds in Enzyme-Catalyzed Reactions; 1. INTRODUCTION; 2. BACTERIAL METABOLISM OF THE FLUOROACETATE; 3. BIOSYNTHESIS OF FLUOROACETATE AND FLUOROTHREONINE; 4. ENZYMATIC DEFLUORINATION; 5. MECHANISM-BASED ENZYME INHIBITORS; 6. REVERSIBLE INHIBITORS; 7. SUMMARY AND OUTLOOK; REFERENCES; Chapter 3
- Synthetic Methods; 1. INTRODUCTION; 2. FLUORINATION BY ELEMENTAL FLUORINE; 3. HYDROGEN FLUORIDE AND ITS AMINE COMPLEXES; 4. SELECTIVE ORTHO-FLUORINATION OF PYRIDINES BY AGF2; 5. DEOXYFLUORINATIONS BY DAST AND RELATED REAGENTS.
- 6. DEDIAZONIATION-FLUORINATION OF AMINES7. GEM-DIFLUORINATIONS; 8. TRIFLUOROMETHYLATIONS; 9. PENTAFLUOROSULFANYL COMPOUNDS; 10. SUMMARY AND OUTLOOK; REFERENCES; Chapter 4
- Fluorinated Amino Acids, Peptides, and Proteins; 1. INTRODUCTION; 2. FLUORINATED LEUCINE; 3. FLUORINATED PROLINE AND ITS EFFECT ON COLLAGEN; 4. FLUORINATED METHIONINES; 5. FLUORINATED TYROSINES; 6. FLUORINATED PHENYLALANINE; 7. PEPTIDE MIMETICS IN DRUG DISCOVERY; 8. SUMMARY AND OUTLOOK; REFERENCES; Chapter 5
- Organofluorine Pharmaceuticals; 1. INTRODUCTION.
- 2. PHARMACEUTICALS WITH GEM-DIFLUOROMETHYLENE AND TRIFLUOROMETHYL MOIETIES3. ANTIBACTERIALS; 4. ANTIMALARIALS; 5. ANTIDIABETICS; 6. NONSTEROIDAL ANTIINFLAMMATORY DRUGS; 7. CORTICOSTEROIDS; 8. ANTIVIRAL DRUGS; 9. ANTIDEPRESSANT DRUGS; 10. ANTIHYPERCHOLESTEROLEMIA DRUGS; 11. ANTICOAGULATING (BLOOD-THINNING) AGENTS; 12. SUMMARY AND OUTLOOK; REFERENCES; Chapter 6
- Organofluorine Anesthetics; 1. INTRODUCTION; 2. MECHANISM OF ACTION OF INHALATION ANESTHETICS; 3. CHIRAL ANESTHETICS; 4. ENVIRONMENTAL IMPACT OF FLUORINATED ANESTHETICS; 5. SYNTHESIS AND TOXICITY OF FLUORINATED ANESTHETICS.