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Organofluorine compounds in biology and medicine /
This book covers topics on biochemically relevant organofluorine compounds and their synthesis and biochemical pathways. Organofluorine compounds have renewed interest in pharmaceutical industry, and therefore a concise book on this topic is highly relevant to the scientific community involved in th...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam, Netherlands :
Elsevier,
[2015]
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| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 100 | 1 | |a Reddy, V. Prakash. | |
| 245 | 1 | 0 | |a Organofluorine compounds in biology and medicine / |c V. Prakash Reddy. |
| 260 | |a Amsterdam, Netherlands : |b Elsevier, |c [2015] | ||
| 300 | |a 1 online resource | ||
| 336 | |a text |b txt |2 rdacontent | ||
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| 347 | |a text file | ||
| 588 | 0 | |a Print version record. | |
| 504 | |a Includes bibliographical references and index. | ||
| 520 | |a This book covers topics on biochemically relevant organofluorine compounds and their synthesis and biochemical pathways. Organofluorine compounds have renewed interest in pharmaceutical industry, and therefore a concise book on this topic is highly relevant to the scientific community involved in this area. | ||
| 505 | 0 | |a Front Cover; Organofluorine Compounds in Biology and Medicine; Copyright; To My Parents and Teachers; Contents; Short Biography; Preface; Importance of this Book; Chapter 1 -- General Aspects of Organofluorine Compounds; 1. INTRODUCTION; 2. C-F BOND STRENGTHS; 3. EFFECT OF THE NEIGHBORING C-F BONDS ON THE C-H BOND DISSOCIATION ENERGIES; 4. EFFECT OF FLUORINE ON THE ACIDITY AND BASICITY; 5. EFFECT OF FLUORINE ON THE METABOLIC STABILITY; 6. EFFECT OF FLUORINE ON THE BIOAVAILABILITY; 7. POSITRON EMISSION TOMOGRAPHY TRACERS; 8. 19F NMR SPECTROSCOPIC TECHNIQUES FOR PROBING BIOCHEMICAL MECHANISMS. | |
| 505 | 8 | |a 9. SUMMARY AND OUTLOOKREFERENCES; Chapter 2 -- Fluorinated Compounds in Enzyme-Catalyzed Reactions; 1. INTRODUCTION; 2. BACTERIAL METABOLISM OF THE FLUOROACETATE; 3. BIOSYNTHESIS OF FLUOROACETATE AND FLUOROTHREONINE; 4. ENZYMATIC DEFLUORINATION; 5. MECHANISM-BASED ENZYME INHIBITORS; 6. REVERSIBLE INHIBITORS; 7. SUMMARY AND OUTLOOK; REFERENCES; Chapter 3 -- Synthetic Methods; 1. INTRODUCTION; 2. FLUORINATION BY ELEMENTAL FLUORINE; 3. HYDROGEN FLUORIDE AND ITS AMINE COMPLEXES; 4. SELECTIVE ORTHO-FLUORINATION OF PYRIDINES BY AGF2; 5. DEOXYFLUORINATIONS BY DAST AND RELATED REAGENTS. | |
| 505 | 8 | |a 6. DEDIAZONIATION-FLUORINATION OF AMINES7. GEM-DIFLUORINATIONS; 8. TRIFLUOROMETHYLATIONS; 9. PENTAFLUOROSULFANYL COMPOUNDS; 10. SUMMARY AND OUTLOOK; REFERENCES; Chapter 4 -- Fluorinated Amino Acids, Peptides, and Proteins; 1. INTRODUCTION; 2. FLUORINATED LEUCINE; 3. FLUORINATED PROLINE AND ITS EFFECT ON COLLAGEN; 4. FLUORINATED METHIONINES; 5. FLUORINATED TYROSINES; 6. FLUORINATED PHENYLALANINE; 7. PEPTIDE MIMETICS IN DRUG DISCOVERY; 8. SUMMARY AND OUTLOOK; REFERENCES; Chapter 5 -- Organofluorine Pharmaceuticals; 1. INTRODUCTION. | |
| 505 | 8 | |a 2. PHARMACEUTICALS WITH GEM-DIFLUOROMETHYLENE AND TRIFLUOROMETHYL MOIETIES3. ANTIBACTERIALS; 4. ANTIMALARIALS; 5. ANTIDIABETICS; 6. NONSTEROIDAL ANTIINFLAMMATORY DRUGS; 7. CORTICOSTEROIDS; 8. ANTIVIRAL DRUGS; 9. ANTIDEPRESSANT DRUGS; 10. ANTIHYPERCHOLESTEROLEMIA DRUGS; 11. ANTICOAGULATING (BLOOD-THINNING) AGENTS; 12. SUMMARY AND OUTLOOK; REFERENCES; Chapter 6 -- Organofluorine Anesthetics; 1. INTRODUCTION; 2. MECHANISM OF ACTION OF INHALATION ANESTHETICS; 3. CHIRAL ANESTHETICS; 4. ENVIRONMENTAL IMPACT OF FLUORINATED ANESTHETICS; 5. SYNTHESIS AND TOXICITY OF FLUORINATED ANESTHETICS. | |
| 650 | 0 | |a Organofluorine compounds. | |
| 650 | 2 | |a Fluorine |x therapeutic use |0 (DNLM)D005461Q000627 | |
| 650 | 6 | |a Compos�es organiques fluor�es. |0 (CaQQLa)201-0027565 | |
| 650 | 7 | |a SCIENCE |x Chemistry |x Organic. |2 bisacsh | |
| 650 | 7 | |a Organofluorine compounds |2 fast |0 (OCoLC)fst01047935 | |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780444537485 |z Texto completo |