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Textbook of Hemophilia
| Autor principal: | |
|---|---|
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Newark :
John Wiley & Sons, Incorporated,
2014.
|
| Colección: | New York Academy of Sciences Ser.
|
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Cover
- Title page
- Copyright page
- Contents
- Contributors
- Historical introduction
- Early history
- Treatment
- Human immunodeficiency virus
- Hepatitis C virus
- New products
- Variant Creutzfeldt-Jakob disease
- The future
- Notes on this edition
- References
- PART I: Introduction
- CHAPTER 1: Overview of hemostasis
- Introduction
- Importance of complex assembly to coagulation
- Extrinsic pathway to blood coagulation
- Attenuation of the procoagulant response
- Conclusion
- Acknowledgment
- References
- Mutation nomenclature
- Disease severity
- References
- CHAPTER 4: Prophylaxis
- Rationale for prophylaxis
- Introduction of prophylaxis
- Prophylaxis in children
- When to start prophylaxis
- Prophylaxis in adults
- Prophylaxis versus on-demand therapy: issues of cost-effectiveness
- Optimal treatment regimen for prophylaxis
- Future issues in prophylaxis
- Conclusion
- References
- PART III: Inhibitors to factor VIII
- CHAPTER 5: Inhibitors to factor VIII: immunology
- Introduction
- Homeostasis of the antifactor VIII immune response
- Lessons from animal models
- Clinical observations
- Characterization of antifactor VIII antibodies
- Factor VIII-specific T cells
- Future perspectives
- References
- CHAPTER 6: Genetic and environmental risk factors for factor VIII inhibitor development
- Introduction
- Genetic factors
- Type of causative mutation
- Major histocompatibility complex
- Immune-regulatory molecules
- Environmental factors
- Factor concentrate-related factors
- Conclusion
- References
- CHAPTER 7: Epidemiology of inhibitors in hemophilia
- Introduction
- Definitions of epidemiology terms