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EBOOKCENTRAL_on1347029813 |
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OCoLC |
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20240329122006.0 |
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m o d |
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230209s2014 xx o ||| 0 eng d |
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|a EBLCP
|b eng
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|d OCLCQ
|d OCLCO
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|d OCLCQ
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| 066 |
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|c (S
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| 020 |
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|a 9781118398272
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| 020 |
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|a 1118398270
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| 035 |
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|a (OCoLC)1347029813
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| 082 |
0 |
4 |
|a 616.1/572
|q OCoLC
|2 23/eng/20230216
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| 049 |
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|a UAMI
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| 100 |
1 |
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|a Lee, Christine A.
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| 245 |
1 |
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|a Textbook of Hemophilia
|h [electronic resource].
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| 260 |
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|a Newark :
|b John Wiley & Sons, Incorporated,
|c 2014.
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| 300 |
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|a 1 online resource (570 p.).
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| 490 |
1 |
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|a New York Academy of Sciences Ser.
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| 500 |
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|a Description based upon print version of record.
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| 505 |
0 |
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|a Cover -- Title page -- Copyright page -- Contents -- Contributors -- Historical introduction -- Early history -- Treatment -- Human immunodeficiency virus -- Hepatitis C virus -- New products -- Variant Creutzfeldt-Jakob disease -- The future -- Notes on this edition -- References -- PART I: Introduction -- CHAPTER 1: Overview of hemostasis -- Introduction -- Importance of complex assembly to coagulation -- Extrinsic pathway to blood coagulation -- Attenuation of the procoagulant response -- Conclusion -- Acknowledgment -- References
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| 505 |
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|a Mutation nomenclature -- Disease severity -- References -- CHAPTER 4: Prophylaxis -- Rationale for prophylaxis -- Introduction of prophylaxis -- Prophylaxis in children -- When to start prophylaxis -- Prophylaxis in adults -- Prophylaxis versus on-demand therapy: issues of cost-effectiveness -- Optimal treatment regimen for prophylaxis -- Future issues in prophylaxis -- Conclusion -- References -- PART III: Inhibitors to factor VIII -- CHAPTER 5: Inhibitors to factor VIII: immunology -- Introduction -- Homeostasis of the antifactor VIII immune response -- Lessons from animal models
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| 505 |
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|a Clinical observations -- Characterization of antifactor VIII antibodies -- Factor VIII-specific T cells -- Future perspectives -- References -- CHAPTER 6: Genetic and environmental risk factors for factor VIII inhibitor development -- Introduction -- Genetic factors -- Type of causative mutation -- Major histocompatibility complex -- Immune-regulatory molecules -- Environmental factors -- Factor concentrate-related factors -- Conclusion -- References -- CHAPTER 7: Epidemiology of inhibitors in hemophilia -- Introduction -- Definitions of epidemiology terms
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| 500 |
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|a Definitions relating to inhibitor terms
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| 590 |
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|a ProQuest Ebook Central
|b Ebook Central Academic Complete
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| 758 |
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|i has work:
|a Textbook of hemophilia (Text)
|1 https://id.oclc.org/worldcat/entity/E39PCGWwwCqxYmmkKTwR7MVW8P
|4 https://id.oclc.org/worldcat/ontology/hasWork
|
| 776 |
0 |
8 |
|i Print version:
|a Lee, Christine A.
|t Textbook of Hemophilia
|d Newark : John Wiley & Sons, Incorporated,c2014
|z 9781118398241
|
| 830 |
|
0 |
|a New York Academy of Sciences Ser.
|
| 856 |
4 |
0 |
|u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=7103607
|z Texto completo
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| 880 |
8 |
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|6 505-00/(S
|a CHAPTER 2: Cellular processing of factor VIII and factor IX -- Factor VIII and hemophilia A -- Factor VIII expression -- Domain structure of factor VIII -- Disulfide bond formation -- Asparagine- and serine/threonine-linked glycosylation -- Chaperone-assisted factor VIII folding -- Tyrosine sulfation -- Phosphorylation of serine and threonine residues -- Proteolytic processing -- Summary -- Factor IX and hemophilia B -- Domain structure of factor IX -- Disulfide bond formation -- Asparagine- and serine/threonine-linked glycosylation -- γ-Carboxylation of glutamic acid residues
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| 880 |
8 |
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|6 505-00/(S
|a β-Hydroxylation of aspartic acid and asparagine -- Tyrosine sulfation -- Phosphorylation of serine and threonine residues -- Factor IX Padua -- Proteolytic processing -- Summary -- Acknowledgments -- References -- PART II: Hemophilia A -- CHAPTER 3: Molecular basis of hemophilia A -- Introduction -- Structure and function of the factor VIII gene (F8) and protein -- F8 gene -- Production of factor VIII protein -- F8 gene defects found in hemophilia A -- Gene rearrangements -- Single-base substitutions in the F8 gene -- Sequence insertions and deletions -- Conclusion -- Public database
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| 938 |
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|a ProQuest Ebook Central
|b EBLB
|n EBL7103607
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| 994 |
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|a 92
|b IZTAP
|
