Molecular and Cellular Toxicology An Introduction.

Detalles Bibliográficos
Autor principal: Stanley, Lesley
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Newark : John Wiley & Sons, Incorporated, 2014.
Colección:New York Academy of Sciences Ser.
Temas:
Electronic books.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Cover
  • Title Page
  • Copyright
  • Contents
  • Foreword
  • Preface
  • Acknowledgements
  • Abbreviations
  • About the Companion Website
  • Chapter 1 Background to Molecular and Cellular Toxicology
  • 1.1 What do we mean by molecular and cellular toxicology?
  • 1.2 Tissues and their maintenance
  • 1.2.1 Stem cells
  • 1.3 Tissue damage
  • 1.3.1 Consequences of tissue injury
  • 1.3.2 Reversible changes in cells and tissues
  • 1.3.3 Irreversible changes in cells and tissues
  • 1.4 Tissue responses to injury
  • 1.4.1 Oxidative stress
  • 1.4.2 Necrosis and apoptosis
  • 1.4.3 Neoplasia
  • 1.4.4 The initiation-promotion paradigm
  • 1.5 Key concepts in toxicology
  • 1.5.1 Risk and hazard
  • 1.5.2 Variability and uncertainty
  • 1.5.3 Threshold and non-threshold dose responses
  • 1.5.4 The regulatory context
  • 1.5.5 Limitations of whole animal studies
  • 1.5.6 Use of human tissues in toxicology
  • 1.6 Summing up
  • Self-assessment questions
  • Background Reading
  • References
  • Chapter 2 Individual Susceptibility to Toxic Chemicals
  • 2.1 Introduction
  • 2.2 Toxicogenetics and toxicogenomics
  • 2.3 Genotyping and phenotyping
  • 2.3.1 Genotyping
  • 2.3.2 Phenotyping
  • 2.3.3 Correlating genotype and phenotype
  • 2.4 Polymorphic xenobiotic metabolism
  • 2.4.1 Polymorphic xenobiotic metabolising enzymes
  • 2.4.2 The role of xenobiotic metabolising polymorphisms in susceptibility to toxic agents
  • 2.5 Study numbers and effect size
  • 2.6 Recent developments
  • 2.6.1 Genome-wide association studies
  • 2.6.2 Collaborative programmes
  • 2.7 The UK Biobank
  • 2.8 Conclusions
  • Self-assessment questions
  • Background Reading
  • References
  • Chapter 3 'Omics Techniques
  • 3.1 'Omics and bioinformatics
  • 3.2 Transcriptomics
  • 3.2.1 Methodology
  • 3.2.2 Proof of principle
  • 3.2.3 Hepatotoxicity
  • 3.2.4 Extrahepatic toxicity
  • 3.3 Proteomics
  • 3.3.1 Methodology
  • 3.4 Metabolomics/metabonomics
  • 3.4.1 MS-based metabolomics
  • 3.4.2 NMR-based metabolomics
  • 3.5 Integrating different types of `omics data
  • 3.5.1 'Omics in drug discovery
  • 3.5.2 'Omics profiles as biomarkers of toxicity
  • 3.6 Remaining issues with `omics approaches
  • 3.7 Conclusions
  • Self-assessment questions
  • Background Reading
  • References
  • Chapter 4 In Vitro Methods for Predicting In Vivo Toxicity
  • 4.1 In vitro toxicology
  • 4.2 Tissue culture
  • 4.2.1 Primary cell cultures
  • 4.2.2 Established cell lines
  • 4.3 Acute toxicity in vitro
  • 4.3.1 Cytotoxicity testing
  • 4.3.2 Choice of cell line
  • 4.3.3 Liver
  • 4.3.4 Skin
  • 4.3.5 Eye
  • 4.4 Repeated dose toxicity
  • 4.5 Reproductive toxicity
  • 4.6 Stem cell-derived systems
  • 4.7 Conclusions
  • Self-assessment questions
  • Background Reading
  • References
  • Chapter 5 In Vitro Methods for Absorption, Distribution, Metabolism and Excretion
  • 5.1 Why study ADME in vitro?
  • 5.2 Absorption
  • 5.2.1 Dermal penetration
  • 5.2.2 Gastrointestinal absorption
  • 5.3 Distribution

Ejemplares similares