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EBOOKCENTRAL_on1347028535 |
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OCoLC |
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20240329122006.0 |
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m o d |
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230209s2014 xx o ||| 0 eng d |
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|a EBLCP
|b eng
|c EBLCP
|d OCLCQ
|d OCLCO
|d OCLCQ
|d EBLCP
|d OCLCQ
|d OCLCL
|d OCLCQ
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| 020 |
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|a 9781118526064
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| 020 |
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|a 1118526066
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| 035 |
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|a (OCoLC)1347028535
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| 082 |
0 |
4 |
|a 615.9/07
|q OCoLC
|2 23/eng/20230216
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| 049 |
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|a UAMI
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| 100 |
1 |
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|a Stanley, Lesley.
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| 245 |
1 |
0 |
|a Molecular and Cellular Toxicology
|h [electronic resource] :
|b An Introduction.
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| 260 |
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|a Newark :
|b John Wiley & Sons, Incorporated,
|c 2014.
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| 300 |
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|a 1 online resource (435 p.).
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| 490 |
1 |
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|a New York Academy of Sciences Ser.
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| 500 |
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|a Description based upon print version of record.
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| 505 |
0 |
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|a Cover -- Title Page -- Copyright -- Contents -- Foreword -- Preface -- Acknowledgements -- Abbreviations -- About the Companion Website -- Chapter 1 Background to Molecular and Cellular Toxicology -- 1.1 What do we mean by molecular and cellular toxicology? -- 1.2 Tissues and their maintenance -- 1.2.1 Stem cells -- 1.3 Tissue damage -- 1.3.1 Consequences of tissue injury -- 1.3.2 Reversible changes in cells and tissues -- 1.3.3 Irreversible changes in cells and tissues -- 1.4 Tissue responses to injury -- 1.4.1 Oxidative stress -- 1.4.2 Necrosis and apoptosis -- 1.4.3 Neoplasia
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| 505 |
8 |
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|a 1.4.4 The initiation-promotion paradigm -- 1.5 Key concepts in toxicology -- 1.5.1 Risk and hazard -- 1.5.2 Variability and uncertainty -- 1.5.3 Threshold and non-threshold dose responses -- 1.5.4 The regulatory context -- 1.5.5 Limitations of whole animal studies -- 1.5.6 Use of human tissues in toxicology -- 1.6 Summing up -- Self-assessment questions -- Background Reading -- References -- Chapter 2 Individual Susceptibility to Toxic Chemicals -- 2.1 Introduction -- 2.2 Toxicogenetics and toxicogenomics -- 2.3 Genotyping and phenotyping -- 2.3.1 Genotyping -- 2.3.2 Phenotyping
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| 505 |
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|a 2.3.3 Correlating genotype and phenotype -- 2.4 Polymorphic xenobiotic metabolism -- 2.4.1 Polymorphic xenobiotic metabolising enzymes -- 2.4.2 The role of xenobiotic metabolising polymorphisms in susceptibility to toxic agents -- 2.5 Study numbers and effect size -- 2.6 Recent developments -- 2.6.1 Genome-wide association studies -- 2.6.2 Collaborative programmes -- 2.7 The UK Biobank -- 2.8 Conclusions -- Self-assessment questions -- Background Reading -- References -- Chapter 3 'Omics Techniques -- 3.1 'Omics and bioinformatics -- 3.2 Transcriptomics -- 3.2.1 Methodology
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| 505 |
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|a 3.2.2 Proof of principle -- 3.2.3 Hepatotoxicity -- 3.2.4 Extrahepatic toxicity -- 3.3 Proteomics -- 3.3.1 Methodology -- 3.4 Metabolomics/metabonomics -- 3.4.1 MS-based metabolomics -- 3.4.2 NMR-based metabolomics -- 3.5 Integrating different types of `omics data -- 3.5.1 'Omics in drug discovery -- 3.5.2 'Omics profiles as biomarkers of toxicity -- 3.6 Remaining issues with `omics approaches -- 3.7 Conclusions -- Self-assessment questions -- Background Reading -- References -- Chapter 4 In Vitro Methods for Predicting In Vivo Toxicity -- 4.1 In vitro toxicology -- 4.2 Tissue culture
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| 505 |
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|a 4.2.1 Primary cell cultures -- 4.2.2 Established cell lines -- 4.3 Acute toxicity in vitro -- 4.3.1 Cytotoxicity testing -- 4.3.2 Choice of cell line -- 4.3.3 Liver -- 4.3.4 Skin -- 4.3.5 Eye -- 4.4 Repeated dose toxicity -- 4.5 Reproductive toxicity -- 4.6 Stem cell-derived systems -- 4.7 Conclusions -- Self-assessment questions -- Background Reading -- References -- Chapter 5 In Vitro Methods for Absorption, Distribution, Metabolism and Excretion -- 5.1 Why study ADME in vitro? -- 5.2 Absorption -- 5.2.1 Dermal penetration -- 5.2.2 Gastrointestinal absorption -- 5.3 Distribution
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| 500 |
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|a 5.3.1 Protein binding
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| 590 |
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|a ProQuest Ebook Central
|b Ebook Central Academic Complete
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| 655 |
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0 |
|a Electronic books.
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| 758 |
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|i has work:
|a Molecular and cellular toxicology (Text)
|1 https://id.oclc.org/worldcat/entity/E39PCGQYX4MT9HF4hJxTHkr76q
|4 https://id.oclc.org/worldcat/ontology/hasWork
|
| 776 |
0 |
8 |
|i Print version:
|a Stanley, Lesley
|t Molecular and Cellular Toxicology
|d Newark : John Wiley & Sons, Incorporated,c2014
|z 9781119952060
|
| 830 |
|
0 |
|a New York Academy of Sciences Ser.
|
| 856 |
4 |
0 |
|u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=7103769
|z Texto completo
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| 938 |
|
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|a ProQuest Ebook Central
|b EBLB
|n EBL7103769
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| 994 |
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|a 92
|b IZTAP
|
