Systems immunology and infection microbiology /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Chen, Bor-Sen (Autor)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Amsterdam : Academic Press, 2021.
Temas:
Immune system > Mathematical models.
Infection > Mathematical models.
Syst�eme immunitaire > Mod�eles math�ematiques.
Infection > Mod�eles math�ematiques.
Infection > Mathematical models
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Front Cover
  • Systems Immunology and Infection Microbiology
  • Copyright Page
  • Contents
  • Preface
  • 1 Introduction to systems immunology and infection microbiology
  • 1.1 Introduction
  • 1.2 Content and general outline of the book
  • I. Systems Immunology
  • 2 Biological network modeling and system identification in systems immunology and infection microbiology
  • 2.1 System identification for gene regulatory network
  • 2.1.1 Least square parameter estimation method
  • 2.1.2 Maximum likelihood parameter estimation method
  • 2.2 System identification of protein-protein interaction network
  • 2.3 System identification of integrated genetic and epigenetic network via high throughput next generation sequencing data
  • 2.4 Conclusion
  • 3 Identifying the gene regulatory network of systems inflammation in humans by system dynamic model via microarray data and ...
  • 3.1 Introduction
  • 3.2 Construction of candidate inflammatory gene regulatory network in response to inflammatory stimulus
  • 3.3 Pruning the candidate gene regulatory network via a dynamic gene regulatory model
  • 3.4 On the construction of inflammatory gene regulatory network in immune system
  • 3.5 Biological insight and discussion
  • 3.6 Conclusion
  • 3.7 Material and methods
  • 3.7.1 Dataset selection
  • 3.7.2 Construction of candidate gene networks of systematic inflammation
  • 3.7.3 Constructing a dynamic regulatory model for gene regulatory network via microarray data
  • 3.7.4 Pruning the candidate gene regulatory network
  • 3.8 Appendix
  • 3.8.1 Dataset selection
  • 3.8.2 Gene network construction
  • 3.8.3 Discussion
  • 4 Dynamic cross-talk analysis among signaling transduction pathways in the vascular endothelial inflammatory response syste ...
  • 4.1 Introduction
  • 4.3.3 Investigation of the interleukin-1 receptor and Toll-like receptor 4 signaling pathways
  • 4.3.4 Cross-talk analysis of the protein-protein interaction networks
  • 4.4 Discussion
  • 4.4.1 Dynamic progression of the protein-protein interaction networks
  • 4.4.2 Specific architecture in the signaling transduction network
  • 4.4.3 Possible existence of Toll-like receptor 4 endogenous ligand
  • 4.4.4 Negative feedback controls of the cross talks among multiple signaling pathways
  • 4.5 Conclusion
  • 4.6 Appendix: Supplementary methods

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