The immune synapse as a novel target for therapy /

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The immune synapse can be compared to a molecular machine that controls T cell activation when getting in contact with an antigen-presenting cell (APC). The immune synapse is involved in the transfer of information across the T cell-APC junction. It plays an essential role in the control and nature...

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Détails bibliographiques
Cote:Libro Electrónico
Autres auteurs: Graca, Luis, MD
Format: Électronique eBook
Langue:Inglés
Publié: Basel ; Boston : [London] : Birkhäuser ; [Springer, distributor], ©2008.
Collection:PIR (Series)
Sujets:
Synapses.
Immune response > Molecular aspects.
Immune response > Regulation.
Antigen Presentation > physiology
Immunological Synapses > physiology
T-Lymphocytes > physiology
Synapses
Réaction immunitaire > Aspect moléculaire.
Réaction immunitaire > Régulation.
MEDICAL > Immunology.
T-Lymphocytes > physiology.
Lymphocyte Activation.
Antigens, CD > physiology.
Antigen Presentation.
Immune Tolerance.
Biomédecine.
Sciences de la vie.
Immune response > Molecular aspects
Immune response > Regulation
Accès en ligne:Texto completo
Table des matières:
  • The immune synapse and T cell activation: regulation by chemokines
  • The induction of regulatory T cells by targeting the immune synapse
  • Infiltrating the immunological synapse: prospects for the use of altered peptide ligands for the treatment of immune pathology
  • Targeting CD4 for the induction of dominant tolerance
  • Anti-CD3: from T cell depletion to tolerance induction
  • Immune modulation by CD40L blockade
  • CTLA-4-immunoglobulin and indoleamine 2,3-dioxygenase in dominant tolerance
  • Adhesion molecules as therapeutic targets
  • E3 ubiquitin ligases and immune tolerance: Targeting the immune synapse from within?
  • FOXP3 biochemistry will lead to novel drug approaches for vaccines and diseases that lack suppressor T cells
  • Transforming growth factor-?: From its effect in T cell activation to a role in dominant tolerance
  • From mice to men: the challenges of developing tolerance-inducing biological drugs for the clinic.

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