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Tetramer Stability and Functional Regulation of Tumor Suppressor Protein p53
This thesis presents the first report of the comprehensive and quantitative analysis of the effects of tumor-derived mutations on the tetrameric structure of tumor suppressor protein p53, which plays a central role in maintaining genomic integrity. Inactivation of p53 via mutation of its gene is a k...
| Call Number: | Libro Electrónico |
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| Main Author: | |
| Corporate Author: | |
| Format: | Electronic eBook |
| Language: | Inglés |
| Published: |
Tokyo :
Springer Japan : Imprint: Springer,
2012.
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| Edition: | 1st ed. 2012. |
| Series: | Springer Theses, Recognizing Outstanding Ph.D. Research,
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| Subjects: | |
| Online Access: | Texto Completo |
Table of Contents:
- Quantitative analysis for p53 tetramerization domain mutants reveals a low threshold for tumor suppressor inactivation
- Stabilization of mutant tetrameric structures by calixarene derivatives
- Inhibition of the transcriptional activity of p53 through hetero-oligomerization.