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Role of inflammation in environmental neurotoxicity /
Role of Inflammation in Environmental Neurotoxicity, Volume Three, in this comprehensive serial, addresses contemporary advances in neurotoxicology by providing authoritative review articles on key issues in the field. Edited by leading subject experts, topics of note in this new release include Neu...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Cambridge, MA, United States :
Academic Press,
2019.
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| Edición: | First edition. |
| Colección: | Advances in neurotoxicology ;
v. 3. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Intro; Title page; Table of Contents; Copyright; Contributors; Preface; Chapter One: An introduction to innate immunity in the central nervous system; Abstract; 1 Immune privilege in the CNS; 2 Innate immunity; 3 Inflammasome activation; 4 Primary CNS cells for innate immunity; 5 The neurovascular unit; 6 Astrocytes; 7 Microglia; 8 Summary; Chapter Two: Neuroinflammation in organophosphate-induced neurotoxicity; Abstract; 1 Introduction; 2 Overview of neuroinflammation; 3 Neuroinflammatory responses to neurotoxic OP exposures; 4 How do OPs trigger neuroinflammatory responses?
- 5 What is the pathophysiologic relevance of OP-induced neuroinflammation?6 Critical data gaps and conclusions; Chapter Three: Neuroimmunotoxicology of the heavy metal toxicant lead; Abstract; 1 Introduction; 2 Developmental neuroimmunologic events; 3 Pb effect on the immune system; 4 Pb influence on cytokines in the CNS and immune system; 5 Function of immune system cells and factors in the brain and Pb modulation; 6 Posited common Pb effects on macrophages/microglia and neurons; 7 Influence of Pb on the HPA axis and sex hormone effects
- 8 Pb effect on endocrine function that may modulate neuroimmune activity9 Summary; Acknowledgments; Chapter Four: The role of manganese in neuroinflammation; Abstract; 1 Introduction; 2 Role of manganese in regulating astrocyte function; 3 Role of manganese in regulating microglial biology; 4 Concluding remarks; Acknowledgments; Chapter Five: Inflammatory mechanisms of abused drugs; Abstract; 1 Introduction; 2 Drugs of abuse and inflammation; 3 Implications; 4 Summary and conclusions; Acknowledgments
- Chapter Six: Overview of peripheral and central inflammatory responses and their contribution to neurotoxicityAbstract; 1 Overview of the inflammatory process; 2 Peripheral inflammation and its contribution to non-neurodegenerative diseases; 3 Selected examples of toxicant or toxicant-pathogen exposures where peripheral inflammation is a major consequence of the exposure and a contributor to the toxicant-induced pathology in the periphery; 4 Central inflammation, a.k.a., neuroinflammation; 5 Overview of microglia
- 6 Role of aging, diet, and sex on microglia phenotype and (inflammatory) function7 Neuroinflammation as a feature of major neurodegenerative diseases; 8 Selected examples of toxicant or toxicant/pathogen exposures where neuroinflammation is a major consequence of the exposure and a contributor to the toxicant-induced pathology in the brain; 9 Contribution of peripherally initiated inflammation to brain dysfunction and pathology; 10 Contribution of centrally initiated inflammation to peripheral dysfunction and pathology