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Progress in medicinal chemistry. Volume 47 /
This volume provides reviews of six topics demonstrating the breadth of the field and recent successes in medicinal chemistry. Each of the first five chapters takes an important biochemical target as its theme and provides an insight into current progress in drug design. The last chapter focuses on...
| Clasificación: | Libro Electrónico |
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| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
[Place of publication not identified] :
Elsevier Science,
2009.
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| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
Tabla de Contenidos:
- Front cover; Progress in Medicinal Chemistry 47; Copyright page; Preface; Contents; List of Contributors; Chapter 1. Calcitonin Gene-Related Peptide Receptor Antagonists for the Treatment of Migraine; Introduction; Migraine and a role for CGRP; Pharmacological characterization of the CGRP receptor; Discovery of CGRP receptor antagonists; Conclusion; Acknowledgements; References; Chapter 2. PDE4 Inhibitors
- A Review of the Current Field; Introduction to the PDE family, focusing on PDE4; Published PDE4 inhibitors; Conclusion and outlook; References
- Chapter 3. Hplus/Kplus ATPase Inhibitors in the Treatment of Acid-Related DisordersIntroduction; The irreversible proton pump inhibitors (PPIs); Modifications to the PPI theme; Acid suppression
- General considerations; Reversible inhibition of Hplus/Kplus ATPase; The binding site for potassium-competitive inhibitors; Concluding remarks; References; Chapter 4. The Adenosine A1 Receptor and its Ligands; Introduction; Pharmacology of Adenosine A1 Receptors; Chemistry of Adenosine A1 Receptor Agonists; Conclusions; References
- Chapter 5. Endothelin Receptor Antagonists: Status and Learning 20 Years OnIntroduction; Medicinal chemistry; Conclusions; References; Chapter 6. Cytochrome P450 Metabolism and Inhibition: Analysis for Drug Discovery; Introduction; Sources of Drug Metabolising Enzymes; In vitro Strategies to Assess Drug Metabolism; Reversible Inhibition; Mechanism-Based Inhibition; In vitro-in vivo Extrapolations (IVIVE) and Associated Prediction of Clinical Risk; CYP Structure-Activity Relationships; CYP1A2; CYP2C9; CYP2C19; CYP2D6; CYP3A4; Other CYP Enzymes; Medicinal Chemistry Design Case Studies
- ConclusionsReferences; Subject Index; Cumulative Index of Authors for Volumes 1-47; Cumulative Index of Subjects for Volumes 1- 47