Analysis of complex disease association studies : a practical guide /

According to the National Institute of Health, a genome-wide association study is defined as any study of genetic variation across the entire human genome that is designed to identify genetic associations with observable traits (such as blood pressure or weight), or the presence or absence of a dise...

Descripción completa

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Zeggini, Eleftheria, Morris, Andrew Paul
Formato: Electrónico eBook
Idioma:Inglés
Publicado: London : Elsevier/Academic, 2011.
Temas:
Human genetics > Variation.
Genetic disorders.
Genetic Diseases, Inborn > genetics
Genome-Wide Association Study > methods
Genetic Predisposition to Disease > genetics
Genetics, Population > methods
Linkage Disequilibrium > genetics
Genetic Variation
Genetic Diseases, Inborn
Variabilit�e g�en�etique.
Maladies g�en�etiques.
Genetic disorders
Human genetics > Variation
Genetik
Krankheit
Erbkrankheit.
Forschung.
Internet Resources.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Genetic architecture of complex disease
  • Population genetics and linkage disequilibrium
  • Genetic association study design
  • Selection of SNPs
  • Genotype calling
  • Data handling
  • Data quality control
  • Single-locus tests of association for population-based studies
  • Population structure
  • Haplotype-based methods
  • Interaction analyses
  • Copy number variant analysis
  • Analysis of family-based association studies
  • Bioinformatics approaches
  • Interpreting association signals
  • Delineating association signals
  • Case study: obesity
  • Case study: rheumatoid arthritis.

Ejemplares similares