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DNA repair : new research /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Kimura, Sakura, Shimizu, Sora
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York : Nova Science Publishers, Inc., [2012]
Colección:DNA and RNA-properties and modifications, functions and interactions, recombination and applications.
Cell biology research progress.
Temas:
Acceso en línea:Texto completo

MARC

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245 0 0 |a DNA repair :  |b new research /  |c Sakura Kimura and Sora Shimizu, editors. 
264 1 |a New York :  |b Nova Science Publishers, Inc.,  |c [2012] 
300 |a 1 online resource. 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
490 1 |a DNA and RNA : properties and modifications, functions and interactions, recombination and applications 
490 1 |a Cell biology research progress 
500 |a Includes bibliographical references and index. 
588 |a Description based on print version record. 
504 |a Includes bibliographical references and index. 
546 |a English. 
505 0 |a DNA REPAIR NEW RESEARCH; DNA REPAIR NEW RESEARCH; LIBRARY OF CONGRESS CATALOGING-IN-PUBLICATION DATA; CONTENTS; PREFACE; Chapter 1: DNA REPAIR AS THE PRIMARY ADAPTIVE FUNCTION OF SEX IN BACTERIA AND EUKARYOTES; ABSTRACT; INTRODUCTION; DNA DAMAGE, A BASIC PROBLEM FOR LIFE; BACTERIAL TRANSFORMATION IS AN ADAPTIVE SEXUAL PROCESS; COMPETENCE DEVELOPMENT IS USUALLY ASSOCIATED WITH STRESSFUL CONDITIONS; BACTERIAL TRANSFORMATION, AS AN ADAPTATION FOR DNA REPAIR; SEX WAS PRESENT EARLY IN THE EVOLUTION OF EUKARYOTES; THE SEXUAL CYCLE IN EUKARYOTIC MICROORGANISMS OCCURS UNDER STRESSFUL CONDITIONS. 
505 8 |a THE SEXUAL CYCLE IN UNICELLULAR OR SIMPLE MULTICELLULAR EUKARYOTES AS A RESPONSE TO DNA DAMAGING CONDITIONSBACTERIAL TRANSFORMATION AND EUKARYOTIC MEIOSIS HAVE FUNDAMENTAL SIMILARITIES; ROLE OF THE RECA PROTEININ TRANSFORMATION; ROLE OF RECA ORTHOLOGS IN MEIOSIS OF UNICELLULAR EUKARYOTES; ROLE OF RECA ORTHOLOGS IN MEIOSIS OF COMPLEX MULTICELLULAR EUKARYOTES; DNA DAMAGE INCREASES MEIOTIC RECOMBINATION; CROSSOVER AND NON-CROSSOVER RECOMBINATION: IMPLICATIONS FOR VARIATION THEORIES; THE FUNCTION OF NCO RECOMBINATION; MEIOTIC HRR IS ESSENTIAL FOR FERTILITY AND EARLY EMBRYONIC SURVIVAL. 
505 8 |a DNA DAMAGES ARE REPAIRED BY HRR DURING MEIOSIS AND MITOSISDURING MEIOSIS HRR LIKELY REMOVES A CLASS OF DNA DAMAGES THAT CANNOT BE ACCURATELY REMOVED DURING MITOSIS; WHAT ARE THE CONSEQUENCES OF DNA DAMAGES IN THE MITOTIC DIVISIONS PRECEDING MEIOSIS IN THE GERM LINE OF MULTICELLULAR ORGANISMS?; CROSSOVER HOTSPOTS IN MEIOSIS; EVOLUTIONARY FORCES MAINTAINING SEX; BENEFITS OF OUTCROSSING SEX; AGING, SEX AND REJUVENATION; PARTHENOGENESIS; CONCLUSION; ACKNOWLEDGMENTS; REFERENCES; Chapter 2: DNA REPAIR AS A NOVEL THERAPEUTIC TARGET IN BREAST CANCER; ABSTRACT; 1. INTRODUCTION. 
505 8 |a 2. DNA-DAMAGING AGENTS IN CANCER TREATMENTS3. DNA-DAMAGE CHECKPOINTS; 4. DNA REPAIR PATHWAYS; 4.1. Homologous Recombination Repair (HRR); 4.2. Non-Homologous End Joining; 4.3. Base Excision Repair; 4.4. Nucleotide Excision Repair; 4.5. Mismatch Repair; 4.6. Direct Repair; 5. DNA REPAIR PROTEINS AS THERAPEUTICTARGETS IN CANCER; 6. TARGETING DNA DOUBLE STRAND BREAKS REPAIR; 6.1. Inhibition of the HRR Pathway by Targeting ATM; 6.2. Inhibition of the NHEJ Pathway by Targeting DNA-PKs; 7. DNA-REPAIR PROTEINS DEREGULATED IN BREAST CANCER. 
505 8 |a 8. THERAPEUTIC INTERVENTION OF BRCA1 AND BRCA2 DEFICIENT BREAST TUMORS9. POLY (ADP-RIBOSE) POLYMERASE (PARP) INHIBITORS; CONCLUSION; ACKNOWLEDGMENTS; REFERENCES; Chapter 3: DNA REPAIR IN THE NERVOUS SYSTEM:A NEW RESEARCH FORNEUROLOGICAL DISORDERS; ABSTRACT; INTRODUCTION; 1. CLASSICAL OVERVIEW OF DNA REPAIR DEFICIENCY AND NEURODEGENERATIVE DISORDERS; 2. DEFECTIVE DNA REPAIR IN MAJOR NEURODEGENERATIVE DISEASES; 3. DEFECTIVE DNA REPAIR IN NEURODEVELOPMENTAL DISORDERS; CONCLUSION; ACKNOWLEDGMENTS; REFERENCES; Chapter 4: TARGETING THE BRCA1 DNA REPAIR PATHWAY FOR CANCER CHEMOTHERAPY; ABSTRACT. 
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650 0 |a DNA repair. 
650 6 |a ADN  |x Réparation. 
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650 7 |a DNA repair.  |2 fast  |0 (OCoLC)fst00886599 
700 1 |a Kimura, Sakura. 
700 1 |a Shimizu, Sora. 
776 0 8 |i Print version:  |t DNA repair  |d New York : Nova Science Publishers, Inc., [2012]  |z 9781621007562 (hardcover)  |w (DLC) 2011038504 
830 0 |a DNA and RNA-properties and modifications, functions and interactions, recombination and applications. 
830 0 |a Cell biology research progress. 
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