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EBSCO_on1162567687 |
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20231017213018.0 |
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110929s2012 nyua ob 001 0 eng |
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|a 2019714275
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|a DLC
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|a 828424701
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|a 9781621008088
|q ebook
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|a 1621008088
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|z 9781621007562
|q hardcover
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|z 1621007561
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|a (OCoLC)1162567687
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|a 572.8/6459
|2 23
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|a UAMI
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245 |
0 |
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|a DNA repair :
|b new research /
|c Sakura Kimura and Sora Shimizu, editors.
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264 |
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|a New York :
|b Nova Science Publishers, Inc.,
|c [2012]
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300 |
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|a 1 online resource.
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336 |
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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338 |
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|a online resource
|b cr
|2 rdacarrier
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490 |
1 |
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|a DNA and RNA : properties and modifications, functions and interactions, recombination and applications
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490 |
1 |
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|a Cell biology research progress
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500 |
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|a Includes bibliographical references and index.
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588 |
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|a Description based on print version record.
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504 |
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|a Includes bibliographical references and index.
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546 |
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|a English.
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505 |
0 |
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|a DNA REPAIR NEW RESEARCH; DNA REPAIR NEW RESEARCH; LIBRARY OF CONGRESS CATALOGING-IN-PUBLICATION DATA; CONTENTS; PREFACE; Chapter 1: DNA REPAIR AS THE PRIMARY ADAPTIVE FUNCTION OF SEX IN BACTERIA AND EUKARYOTES; ABSTRACT; INTRODUCTION; DNA DAMAGE, A BASIC PROBLEM FOR LIFE; BACTERIAL TRANSFORMATION IS AN ADAPTIVE SEXUAL PROCESS; COMPETENCE DEVELOPMENT IS USUALLY ASSOCIATED WITH STRESSFUL CONDITIONS; BACTERIAL TRANSFORMATION, AS AN ADAPTATION FOR DNA REPAIR; SEX WAS PRESENT EARLY IN THE EVOLUTION OF EUKARYOTES; THE SEXUAL CYCLE IN EUKARYOTIC MICROORGANISMS OCCURS UNDER STRESSFUL CONDITIONS.
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505 |
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|a THE SEXUAL CYCLE IN UNICELLULAR OR SIMPLE MULTICELLULAR EUKARYOTES AS A RESPONSE TO DNA DAMAGING CONDITIONSBACTERIAL TRANSFORMATION AND EUKARYOTIC MEIOSIS HAVE FUNDAMENTAL SIMILARITIES; ROLE OF THE RECA PROTEININ TRANSFORMATION; ROLE OF RECA ORTHOLOGS IN MEIOSIS OF UNICELLULAR EUKARYOTES; ROLE OF RECA ORTHOLOGS IN MEIOSIS OF COMPLEX MULTICELLULAR EUKARYOTES; DNA DAMAGE INCREASES MEIOTIC RECOMBINATION; CROSSOVER AND NON-CROSSOVER RECOMBINATION: IMPLICATIONS FOR VARIATION THEORIES; THE FUNCTION OF NCO RECOMBINATION; MEIOTIC HRR IS ESSENTIAL FOR FERTILITY AND EARLY EMBRYONIC SURVIVAL.
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505 |
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|a DNA DAMAGES ARE REPAIRED BY HRR DURING MEIOSIS AND MITOSISDURING MEIOSIS HRR LIKELY REMOVES A CLASS OF DNA DAMAGES THAT CANNOT BE ACCURATELY REMOVED DURING MITOSIS; WHAT ARE THE CONSEQUENCES OF DNA DAMAGES IN THE MITOTIC DIVISIONS PRECEDING MEIOSIS IN THE GERM LINE OF MULTICELLULAR ORGANISMS?; CROSSOVER HOTSPOTS IN MEIOSIS; EVOLUTIONARY FORCES MAINTAINING SEX; BENEFITS OF OUTCROSSING SEX; AGING, SEX AND REJUVENATION; PARTHENOGENESIS; CONCLUSION; ACKNOWLEDGMENTS; REFERENCES; Chapter 2: DNA REPAIR AS A NOVEL THERAPEUTIC TARGET IN BREAST CANCER; ABSTRACT; 1. INTRODUCTION.
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505 |
8 |
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|a 2. DNA-DAMAGING AGENTS IN CANCER TREATMENTS3. DNA-DAMAGE CHECKPOINTS; 4. DNA REPAIR PATHWAYS; 4.1. Homologous Recombination Repair (HRR); 4.2. Non-Homologous End Joining; 4.3. Base Excision Repair; 4.4. Nucleotide Excision Repair; 4.5. Mismatch Repair; 4.6. Direct Repair; 5. DNA REPAIR PROTEINS AS THERAPEUTICTARGETS IN CANCER; 6. TARGETING DNA DOUBLE STRAND BREAKS REPAIR; 6.1. Inhibition of the HRR Pathway by Targeting ATM; 6.2. Inhibition of the NHEJ Pathway by Targeting DNA-PKs; 7. DNA-REPAIR PROTEINS DEREGULATED IN BREAST CANCER.
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505 |
8 |
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|a 8. THERAPEUTIC INTERVENTION OF BRCA1 AND BRCA2 DEFICIENT BREAST TUMORS9. POLY (ADP-RIBOSE) POLYMERASE (PARP) INHIBITORS; CONCLUSION; ACKNOWLEDGMENTS; REFERENCES; Chapter 3: DNA REPAIR IN THE NERVOUS SYSTEM:A NEW RESEARCH FORNEUROLOGICAL DISORDERS; ABSTRACT; INTRODUCTION; 1. CLASSICAL OVERVIEW OF DNA REPAIR DEFICIENCY AND NEURODEGENERATIVE DISORDERS; 2. DEFECTIVE DNA REPAIR IN MAJOR NEURODEGENERATIVE DISEASES; 3. DEFECTIVE DNA REPAIR IN NEURODEVELOPMENTAL DISORDERS; CONCLUSION; ACKNOWLEDGMENTS; REFERENCES; Chapter 4: TARGETING THE BRCA1 DNA REPAIR PATHWAY FOR CANCER CHEMOTHERAPY; ABSTRACT.
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590 |
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|a eBooks on EBSCOhost
|b EBSCO eBook Subscription Academic Collection - Worldwide
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650 |
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0 |
|a DNA repair.
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650 |
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6 |
|a ADN
|x Réparation.
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650 |
|
7 |
|a SCIENCE
|x Life Sciences
|x Genetics & Genomics.
|2 bisacsh
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650 |
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7 |
|a DNA repair.
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|0 (OCoLC)fst00886599
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700 |
1 |
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|a Kimura, Sakura.
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700 |
1 |
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|a Shimizu, Sora.
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776 |
0 |
8 |
|i Print version:
|t DNA repair
|d New York : Nova Science Publishers, Inc., [2012]
|z 9781621007562 (hardcover)
|w (DLC) 2011038504
|
830 |
|
0 |
|a DNA and RNA-properties and modifications, functions and interactions, recombination and applications.
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830 |
|
0 |
|a Cell biology research progress.
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856 |
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