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Bioisosteres in medicinal chemistry.

Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. The first par...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Brown, Nathan (Medicinal chemist), Mannhold, Raimund, 1948-, Kubinyi, Hugo, Folkers, Gerd
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Hoboken : John Wiley & Sons, 2012.
Colección:Methods and principles in medicinal chemistry ; v. 54.
Temas:
Acceso en línea:Texto completo
Descripción
Sumario:Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered, while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part covers the four key methodologi.
Descripción Física:1 online resource
Bibliografía:References; Part Two: Data; 4 BIOSTER: A Database of Bioisosteres and Bioanalogues; 4.1 Introduction; 4.2 Historical Overview and the Development of BIOSTER; 4.2.1 Representation of Chemical Transformations for Reaction Databases; 4.2.2 The Concept of ''Biosteric Transformation''; 4.2.3 Other Analogue and Bioisostere Databases; 4.3 Description of BIOSTER Database; 4.3.1 Coverage and Selection Criteria; 4.3.2 Sources; 4.3.3 Description of the Layout of Database Records; 4.3.3.1 ID Code; 4.3.3.2 Biosteric Transformation; 4.3.3.3 Citation (s); 4.3.3.4 Activity; 4.3.3.5 Fragments.
ISBN:9783527654307
3527654305
9783527654338
352765433X