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016 7 |a 020985451  |2 Uk 
019 |a 1379193420 
020 |a 9780323917155  |q (electronic bk.) 
020 |a 0323917151  |q (electronic bk.) 
020 |z 9780323913676 
020 |z 0323913679 
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050 4 |a RC271 
060 1 0 |a QZ 202 
082 0 4 |a 616.994042  |2 23/eng/20230523 
245 0 0 |a Epigenetic cancer therapy /  |c edited by Steven Gray. 
250 |a Second edition. 
264 1 |a Amsterdam :  |b Academic Press,  |c 2023. 
300 |a 1 online resource (xxv, 745 pages) :  |b illustrations 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
490 1 |a Translational epigenetics series 
504 |a Includes bibliographical references and index. 
588 0 |a Print version record. 
505 0 |a <P>1. Introduction</p> <p><b>Part 1: Introduction and Key Concepts</b> 2. DNA Methylation and Hydroxymethylation in Cancer 3. Writers, Readers, and Erasers of Epigenetic Marks 4. Oncohistones 5. MicroRNAs, epi-miRNAs and Cancer 6. Long Noncoding RNAs and Cancer 7. The Epitranscriptome 8. Mining the Epigenetic Landscape: Surface Mining or Deep Underground - Alecsandar Milosavljevic 9: Epigenetics Clocks: Concepts for Carcinogenesis10: Environmental Pollution Epigenetics and Cancer</p> <p><b>Part 2: Epigenetics and Cancer</b> 11. Development of Epigenetic Targeted Therapies in Hematological Malignancies: From Serendipity to Synthetic Lethality 12. Epigenetic Therapy in Lung Cancer 13. Breast Cancer Epigenetics 14. Therapeutic Applications of the Prostate Cancer Epigenome 15. Neuroblastoma</p> <p><b>Part 3: Targeting Aberrant Epigenetics</b> 16. Nutritional Epigenetic Regulators in the Field of Cancer: New Avenues for Chemopreventive Approaches -- 17. Emerging Epigenetic Therapies- Lysine Methyltransferase/PRC Complex Inhibitors 18. Inhibitors of Jumonji C-Domain Histone Demethylases 19. Emerging Epigenetic Therapies: Lysine Acetyltransferase Inhibitors 20: Histone Deacetylases 21. Emerging Epigenetic Therapies</p> <p><b>Part 4: Issues to Overcome/Areas of Concern</b> 22. Genetic Intratumoral Heterogeneity 23. Challenges for single cell epigenetic analysis 24. Epigenetics Underpinning DNA Damage Repair 25. Epigenetics of Cisplatin Resistance 26. Therapeutically Targeting Epigenetic Regulation of Cancer Stem Cells </p> <p><b>Part 5: Future Directions: Translation to the Clinic</b> 27. Personalized Epigenetic Therapy-Chemosensitivity Testing 28. Personalized Therapy-Epigenetic Profiling as Predictors of Prognosis and Response 29. Epigenetic Priming - Fact or Fallacy 30. CRISPR and epigenetics 31. Epigenetics and CAR-T </p> 
650 0 |a Cancer  |x Genetic aspects. 
650 0 |a Cancer  |x Treatment. 
650 0 |a Epigenesis. 
650 2 |a Neoplasms  |x genetics  |0 (DNLM)D009369Q000235 
650 2 |a Epigenesis, Genetic  |0 (DNLM)D044127 
650 2 |a Neoplasms  |x therapy  |0 (DNLM)D009369Q000628 
650 2 |a Genetic Therapy  |0 (DNLM)D015316 
650 6 |a Cancer  |x Aspect g&#xFFFD;en&#xFFFD;etique.  |0 (CaQQLa)201-0004687 
650 6 |a Cancer  |x Traitement.  |0 (CaQQLa)201-0004693 
650 6 |a &#xFFFD;Epig&#xFFFD;en&#xFFFD;ese.  |0 (CaQQLa)201-0066257 
650 6 |a Th&#xFFFD;erapie g&#xFFFD;enique.  |0 (CaQQLa)201-0193146 
650 7 |a Cancer  |x Genetic aspects  |2 fast  |0 (OCoLC)fst00845368 
650 7 |a Cancer  |x Treatment  |2 fast  |0 (OCoLC)fst00845538 
650 7 |a Epigenesis  |2 fast  |0 (OCoLC)fst00914128 
700 1 |a Gray, Steven G.  |c (Thoracic oncology researcher),  |e editor. 
776 0 8 |i Print version:  |t Epigenetic cancer therapy.  |b Second edition.  |d Amsterdam : Academic Press, 2023  |z 9780323913676  |w (OCoLC)1372469054 
830 0 |a Translational epigenetics series. 
856 4 0 |u https://sciencedirect.uam.elogim.com/science/book/9780323913676  |z Texto completo