Ionizing radiation and the immune response. Part A /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Mirjolet, C�eline, Galluzzi, Lorenzo
Formato: Electrónico eBook
Idioma:Inglés
Publicado: [S.l.] : Academic Press, 2023.
Colección:International review of cell and molecular biology ; v. 376
Temas:
Ionizing radiation > Health aspects.
Immune response.
R�eaction immunitaire.
Immune response
Ionizing radiation > Health aspects
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • Ionizing Radiation and the Immune Response
  • Part A
  • Copyright
  • Contents
  • Contributors
  • Chapter One: Are charged particles a good match for combination with immunotherapy? Current knowledge and perspectives
  • 1. Introduction
  • 2. Charged particles: physics and biology
  • 2.1. Physical characteristics of charged particle therapy as opposed to photon therapy
  • 2.2. Resulting biological effects and enhanced biological effectiveness for cell death related effects
  • 3. Impact of charged particles on the immune response
  • 3.1. Biological differences with respect to immunogenicity of the cell death modality
  • 3.2. Pre-clinical studies suggesting a match of charged particles with immunotherapy
  • 3.3. Impact on immune cells and the tumor immune microenvironment
  • 3.4. Sparing of normal tissue leads to reduced lymphopenia
  • 3.5. Potential for charged particles in combination with immunotherapy and clinical studies
  • 4. Future perspectives
  • 5. Conclusions
  • Reference
  • Chapter Two: Radiation-induced immune response in novel radiotherapy approaches FLASH and spatially fractionated radiothe ...
  • 1. Introduction
  • 2. FLASH radiation therapy and the immune system
  • 2.1. Immune cell sparing in blood and normal tissues
  • 2.2. FLASH-RT effects on tumor immune microenvironment
  • 2.3. FLASH-RT effects on cytokines production and distant effects
  • 2.4. Combination of FLASH-RT with immunotherapy
  • 3. Spatially fractionated radiotherapy and radiation-induced immune response
  • 3.1. Impact of SFRT on the tumor microenvironment
  • 3.2. SFRT effects on inflammation and cytokine secretion
  • 3.3. SFRT impact on peripheral immune cells
  • 3.4. Abscopal effect and distant effect of healthy tissue irradiation
  • 3.5. Long-term antitumor immunity
  • 3.6. Combination of SFRT and immunotherapy
  • 4. Conclusions
  • Acknowledgments.
  • 3.2.1. T cells
  • 3.2.2. Tumor-associated macrophages and myeloid derived suppressor cells
  • 3.2.3. Dendritic cells
  • 3.2.4. Natural killers
  • 4. Radiation therapy and fatty acid metabolism
  • 4.1. Fatty acid metabolism promotes radiation therapy resistance
  • 4.2. Impact of FA metabolism on RT-induced type I IFN
  • 5. Conclusions
  • Acknowledgments
  • Conflict of interest statement
  • References
  • Chapter Six: Chemotherapy to potentiate the radiation-induced immune response
  • 1. Introduction
  • 2. Immunostimulating effects of chemoradiation
  • 2.1. Inducing immunogenic cell death
  • 2.2. Increase of tumor mutational burden
  • 2.3. Promoting dendritic cell maturation and trafficking
  • 2.4. Inducing intratumoral T cells infiltration
  • 3. Immune suppressive effects of chemoradiation therapy
  • 3.1. Regulatory T cells
  • 3.2. Macrophages and myeloid-derived-suppressor-cells
  • 3.3. Adaptive immune resistance
  • 4. Combining CRT with immunotherapy: A promising strategy
  • 4.1. Preclinical studies
  • 4.2. Synergistic effects of CRT-IO combo in human cancers
  • 5. Conclusion
  • Acknowledgments
  • Author contributions
  • References.

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