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Bidirectional gene promoters : transcription system and chromosomal structure /
Recent studies in human genetics and in silico analyses have revealed that a number of genes are head-head orientated with other genes or non-coding RNAs. The expression of regulatory element-containing 5'-upstream regions of gene pairs are referred to as bi-directional promoters and are though...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
[Place of publication not identified] :
Elsevier,
2022.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Intro
- Bidirectional Gene Promoters: Transcription System and Chromosomal Structure
- Copyright
- Contents
- Preface
- Chapter 1: Introductory Chapter: DNA Replication and Transcription
- DNA replication origin in eukaryotic cells
- Helicases that regulate transcription and DNA replication
- From the RNA world to the DNA/RNA/protein world
- Viruses and transposable elements
- Alterations in transcriptional state during the aging process
- Conclusion
- References
- Section I: Biological significances of the bidirectional transcription in eukaryotic cells
- Chapter 2: Mitochondrial function and immune response-regulating factor-encoding gene promoters
- Origin of mitochondria and endosymbiosis
- Known functions of mitochondria
- Mitochondrial dysfunction and human diseases
- Bidirectional promoters of human mitochondrial function-associated genes
- Immune responses and mitochondrial functions are dependent on each other
- Bidirectional promoters of human interferon-stimulated gene (ISG) promoters
- Glycolysis enzyme-encoding gene promoters
- Conclusion
- References
- Chapter 3: DNA repair factor-encoding gene promoters
- Slight but appropriate low levels of mutation are essential for evolution
- Classification of the DNA repair systems in mammalian cells
- Dysfunctions in the DNA repair system that cause human diseases
- Xeroderma pigmentosum (XP) and Cockayne syndrome (CS)
- Fanconi anemia (FA)
- Ataxia telangiectasia (AT)
- Bloom syndrome (BS), Rothmund-Thomson syndrome (RTS), and Werner syndrome (WS)
- Immunological diseases
- Cancer
- Neurodegenerative diseases
- Bidirectional promoters of human DNA repair factor-encoding genes
- Mitonuclear communication, telomere maintenance, and nicotinamide adenine dinucleotide (NAD+)
- DNA repair factors that localize in mitochondria
- Cross-talk between DNA repair and immunological responses
- Conclusion
- References
- Chapter 4: Regulation of non-coding RNA promoters
- From the RNA world: re-evaluation of non-coding RNAs (ncRNAs)
- Classification of ncRNAs and relationships with DNA repair, mitochondrial function, and the immune system
- The ncRNAs that may play roles in pathogenesis of age-related human diseases
- Bidirectional promoters of lncRNAs and the head-head linked genes
- ANRIL_CDKN2A (p16-encoding)
- BACE1-AS_BACE1 (overlapping)
- BDNF-AS_LIN7C
- GAS5_ZBTB37
- HOTAIR_HOX11 (overlapping)
- NBR2_BRCA1
- NEAT1_LOC107984338
- SOD2 (GClnc1)_ACAT2
- TUG1_MORC2
- ZFAS1_ZNFX1
- Bidirectional promoters of the miRNA host and the oppositely transcribed partner genes
- DNA replication/repair/cell cycle control: MCM7, CTDSPL
- Apoptosis and autophagy: AATK, AEN, VMP1
- Mitochondrial functions and metabolisms: ATP5MD, PANK1, PANK2, PDE4D, SREBF2