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00000cam a2200000 a 4500 |
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SCIDIR_on1344187640 |
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OCoLC |
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20231120010703.0 |
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m o d |
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cr un|---aucuu |
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220912s2022 mau o 000 0 eng d |
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|a YDX
|b eng
|c YDX
|d OPELS
|d EBLCP
|d OCLCF
|d OCLCQ
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|a 9780323997812
|q (electronic bk.)
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|a 0323997813
|q (electronic bk.)
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|z 9780323997805
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|z 0323997805
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|a (OCoLC)1344187640
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4 |
|a QP551
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0 |
4 |
|a 572.645
|2 23
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|a Disorders of protein synthesis /
|c Edited by Rossen Donev.
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| 260 |
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|a Cambridge, MA :
|b Academic Press,
|c 2022.
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|a 1 online resource.
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|a Advances in protein chemistry and structural biology ;
|v 132
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|a Print version record.
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|a Intro -- Disorders of Protein Synthesis -- Copyright -- Contents -- Contributors -- Chapter One: Translation termination codons in protein synthesis and disease -- 1. Ribosome fidelity and translation termination -- 2. Nonsense mutations and the mRNA quality control -- 3. Ribosome readthrough -- 3.1. Mechanism, programmed readthrough and natural vs premature stop codons -- 3.2. Readthrough-inducing compounds -- 3.3. The determinants of readthrough -- 3.3.1. The sequence context -- 3.3.2. The reinserted amino acid -- 4. Readthrough induction as a therapeutic approach for PTC suppression
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|a 4.1. Cystic fibrosis -- 4.2. Duchenne muscular dystrophy -- 4.3. Coagulation factor deficiencies -- 4.4. Lysosomal storage disorders -- 5. Conclusions -- Author contributions -- Funding -- Conflicts of interest -- References -- Chapter Two: The disturbance of protein synthesis/degradation homeostasis is a common trait of age-related neurodegenerat ... -- 1. Introduction -- 2. Proteostasis: The balance between synthesis, folding and degradation -- 2.1. Protein re-folding and surveillance -- 2.1.1. Molecular chaperones -- 2.1.2. The unfolded protein response -- 2.1.3. The integrated stress response
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|a 2.2. Protein degradation -- 2.2.1. The ubiquitin proteome system -- 2.2.2. Autophagy -- 3. The proteostasis network in the brain -- 3.1. Evidence of aberrant proteostasis in age-related neurodegenerative diseases -- 3.1.1. Alzheimer�s disease -- 3.1.2. Parkinson�s disease -- 3.1.3. Amyotrophic lateral sclerosis -- References -- Chapter Three: Computational and structural investigation of Palmitoyl-Protein Thioesterase 1 (PPT1) protein causing Neur ... -- 1. Introduction -- 2. Materials and methods -- 2.1. Sequence and mutations retrieval
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|a 2.2. Deleteriousness, stability, and conservation analysis -- 2.3. Structural effects prediction -- 2.4. Molecular dynamics simulation (MDS) analysis -- 3. Results -- 3.1. Sequence and mutations retrieval -- 3.2. Deleteriousness, stability, and conservation analysis -- 3.3. Structural effects prediction -- 3.4. Molecular dynamics simulations -- 4. Discussion -- 5. Conclusion -- Acknowledgment -- Role of funding source -- Author contributions -- Conflict of interest -- References
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|a Chapter Four: Translation initiation and its relationship with metabolic mechanisms in cancer development, progression an ... -- 1. Introduction -- 2. Translation initiation and its regulation -- 2.1. The formation of the preinitiation complex (PIC) -- 2.2. mRNA activation by assembly with eIF4F complex and binding to the 43S PIC -- 2.2.1. Formation of mRNA structures in 5 untranslated region (5UTR) -- 2.3. Scanning of the mRNA-bound ribosomal complex along with the 5UTR mRNA -- 2.4. Formation of the 80S ribosome -- 3. The impact of translation initiation in cancer
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|a Proteins
|x Synthesis.
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| 650 |
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7 |
|a Proteins
|x Synthesis.
|2 fast
|0 (OCoLC)fst01079764
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|a Electronic books.
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| 700 |
1 |
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|a Donev, Rossen.
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| 776 |
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|i ebook version :
|z 9780323997812
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| 776 |
0 |
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|c Original
|z 0323997805
|z 9780323997805
|w (OCoLC)1296534005
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| 856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/bookseries/18761623/132
|z Texto completo
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