Vitamin B12

Bibliographic Details
Call Number:Libro Electrónico
Other Authors: Litwack, Gerald
Format: Electronic eBook
Language:Inglés
Published: Cambridge, MA : Academic Press, 2022.
Series:Vitamins and hormones ; v. 119.
Subjects:
Vitamin B12.
Vitamin B 12
Vitamine B12.
Vitamin B12
Online Access:Texto completo
Table of Contents:
  • Intro
  • Vitamin B12
  • Copyright
  • Contents
  • Contributors
  • Preface
  • Chapter One: Insertion of cobalt into tetrapyrroles
  • 1. Introduction
  • 1.1. Vitamin B12 synthesis
  • 1.2. Cobalt selectivity
  • 2. Aerobic B12 biosynthesis
  • 2.1. CobNST structure
  • 2.2. CobNST function
  • 2.3. CobNST selectivity
  • 3. Anaerobic B12 biosynthesis
  • 3.1. Historical background
  • 3.2. CbiK structure
  • 3.3. CbiK function
  • 3.4. CbiK selectivity
  • 4. Conclusions and future directions
  • References
  • Chapter Two: Application of bioorganometallic B12 in green organic synthesis
  • 1. Vitamin B12
  • 1.1. Design for vitamin B12 inspired reactions
  • 1.2. Vitamin B12 derivatives
  • 2. B12 inspired reactions
  • 2.1. Photo-driven B12 catalyzed dechlorination reaction
  • 2.2. Photo-driven B12 catalyzed organic synthesis
  • 2.3. B12-titania hybrid catalyst system
  • 3. Electrochemical reactions catalyzed by vitamin B12 derivative
  • 3.1. B12 catalyzed electrochemical dehalogenation of organic halides pollutants
  • 3.2. Electroorganic synthesis catalyzed by vitamin B12 derivative
  • Co-H complex of vitamin B12 derivative for alkene and alkyne reduction
  • 4. Conclusion and future directions
  • Acknowledgments
  • References
  • Chapter Three: Cobamide remodeling
  • 1. Introduction
  • 2. Cobamide diversity and distribution
  • 2.1. Cobamide analogs
  • 2.2. Distribution of cobamide analogs
  • 2.3. Biosynthesis of cobamide analogs
  • 3. Cobamide remodeling proteins
  • 3.1. Amidohydrolase CbiZ
  • 3.2. Phosphodiesterase CbiR
  • 3.3. CobS-mediated direct remodeling
  • 4. Conclusions and outlook
  • References
  • Chapter Four: Cubilin, the intrinsic factor-vitamin B12 receptor
  • 1. Introduction
  • 2. Expression sites of cubilin, Lrp2 and Amn
  • 3. Cubilin, the intrinsic factor-vitamin B12 receptor
  • 4. Amnionless
  • 5. Megalin/Lrp2
  • 6. The receptor complex CUBN/AMN, LRP2 and their partners (Fig. 2)
  • 7. Cubilin in the kidney
  • 8. Cubilin and receptor-mediated endocytosis
  • 9. Cubilin/Amn, Lrp2, DAB2
  • 10. Regulation of cubilin expression
  • 11. Cubilin in vitamin B12 homeostasis vitamin B12 (Fig. 3)
  • 12. Cobalamin absorption and transport (Fig. 4)
  • 13. Renal handling of vitamin B12
  • 14. IGS or juvenile megaloblastic anemia (Fig. 5)
  • 15. Cubilin in pathology
  • 15.1. Renal pathology
  • 16. Cubilin dysfunction in Fanconi-Bickel, Dent and Lowe syndromes
  • 17. Cubilin in diabetes, the vitamin D/micronutrient connection
  • 18. Cubilin in neural tube defects
  • 19. Cubilin as a risk variant and/or prognostic factor in cancer progression
  • 20. Cubilin in animal studies
  • 20.1. Cubilin in embryonic nutrition and development (Fig. 6)
  • 20.2. Cubilin inactivation in the mouse
  • 20.3. Cubilin inactivation in the kidney
  • 21. Breed-specific cubilin mutations in dogs
  • 22. Conclusion
  • References
  • Chapter Five: Membrane transport of cobalamin
  • 1. Introduction

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