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Epigenetics of stress and stress disorders /
Epigenetics of Stress and Stress Disorders, Volume 31 in the Translational Epigenetics series, examines the epigenetic mechanisms involved in modifying DNA or gene expression following prolonged stress and/or trauma. Sections introduce both genetic and psychiatric foundations, including modes of epi...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London, United Kingdom ; San Diego, CA, United States ; Cambridge, MA, United States ; Kidlington, Oxford, United Kingdom :
Elsevier, Academic Press, an Imprint of Elsevier,
[2022]
|
| Colección: | Translational epigenetics series ;
v. 31. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Intro
- Epigenetics of Stress and Stress Disorders
- Copyright
- Contents
- Contributors
- Foreword
- Acknowledgments
- Chapter 1 The physiology of stress and the human body's response to stress
- Introduction
- Stress as an environmental factor
- The basics of the stress response
- Sympathetic and parasympathetic systems
- Allostasis and allostatic load
- Allostatic load and disease burden
- Allostatic load and the brain
- Cortisol as the primary driver of the chronic stress response
- Glucocorticoids and the brain
- Molecular mechanism of cortisol action
- Intracellular negative feedback and glucocorticoid resistance
- Epigenetics
- Effect of chronic stress on systemic cortisol dynamics
- Effect of chronic stress on neurotransmitter function and behavior
- Conclusion
- Acknowledgments
- References
- Chapter 2 Posttraumatic stress disorder: Diagnosis, measurement, and assessment
- Introduction to PTSD and stress-related disorders
- Proper diagnosis according to DSM-5
- Risk factors for PTSD
- Comorbidities and complications of PTSD
- Differential diagnosis of PTSD
- PTSD vs acute stress disorder
- Tools for diagnosis
- Life events checklist for DSM 5 (LEC-5)
- PTSD checklist for DSM-5 (PCL-5)
- Clinician-administered PTSD scale 5 (CAPS-5)
- References
- Chapter 3 Nikola Tesla: An autobiographical case study of trauma and resilience
- Introduction a
- Nikola Tesla's mental symptoms and mental experiences
- References
- Chapter 4 Management of posttraumatic stress disorder
- Introduction
- Management algorithm
- Treatment algorithm
- Shared decision making
- The role of PTSD checklist-5 (PCL-5) in management
- Trauma-focused psychotherapies
- Prolonged exposure therapy
- Cognitive processing therapy
- Eye movement desensitization and reprocessing
- Specific cognitive-behavioral therapies for PTSD.
- Brief eclectic psychotherapy
- Narrative exposure therapy
- Written narrative exposure
- Second-line therapies
- Nontrauma-based psychotherapies
- Other psychotherapies
- First-line pharmacotherapies
- Second-line pharmacotherapies
- Medications to avoid in PTSD treatment
- Complementary and alternative techniques
- Internet-based and tele-therapies
- Management of PTSD comorbidities
- Summary
- References
- Chapter 5 Depression and epigenetics: Epidemiology, pathophysiology, diagnosis, and assessment
- Epidemiology
- Neurobiology and pathophysiology
- Genetic predisposition
- Environmental factors and gene-environment interactions
- Epigenetic mechanisms
- Pathophysiology
- Monoamine dysfunction
- Glutamate dysfunction
- Hypothalamic-pituitary-adrenal (HPA) axis dysfunction
- Immune system dysregulation
- Dysfunction of neuroplasticity and neurogenesis
- Circadian rhythm dysregulation
- Dysregulation of opioid and endocannabinoid systems
- Diagnosis and assessment
- Diagnostic criteria, classification, and symptomatology
- Major depressive disorder
- MDD subtypes and specifiers
- Comorbidities
- Suicide risk
- Screening, diagnosis, and measurement-based care
- Screening and diagnosis
- Measurement-based care
- References
- Chapter 6 Depression management and pharmacoepigenetics
- Principles of depression management
- General principles
- Treatment phases
- Measurement-based and evidence-informed care
- Stepped care and chronic disease management model
- Depression management strategies
- Suicide risk management
- Treatment selection
- Pharmacotherapy
- Antidepressant selection: Clinical factors
- Antidepressant selection: Nonclinical factors
- Management of partial or lack of response
- Monitoring and management of adverse reactions
- Psychotherapy
- Neurostimulation.
- Depression management in special populations
- Pharmacoepigenetics
- References
- Chapter 7 Psychotherapy for stress disorders: A military perspective
- Overview of behavioral health in the military health system
- Posttraumatic stress disorder
- Pretraumatic factors
- Peritraumatic factors
- Posttraumatic factors
- Treatment
- Psychotherapy for PTSD
- Prolonged exposure
- Cognitive processing therapy
- Eye movement desensitization and reprocessing
- Conclusion
- Depression
- Treatment
- Epigenetics and psychotherapy
- Conclusion
- References
- Further reading
- Chapter 8 How stress affects gene expression through epigenetic modifications
- Introduction-Biology of stress
- Epigenetics
- DNA methylation
- Histone modification and noncoding RNA
- Gene expression
- Stress-induced epigenetic and gene expression changes in animal models
- Stress-induced epigenetic modifications and gene expression changes in humans
- DNA methylation and gene expression changes of candidate genes
- Genome-wide studies of DNA methylation and gene expression changes
- Timing of stress is important-epigenetic modifications and gene expression changes at different times during life
- Epigenetic effects of stress in early life
- Epigenetic effects of stress in childhood
- Effects of stress in adulthood
- Transgenerational transmission of stress-induced epigenetic marks
- Limitations and future directions
- References
- Chapter 9 Proposed effect of epigenetic alterations on stress-related disorders
- Introduction
- Genetic background and mechanisms of stress-related disorders
- Genetic background of depressive disorders
- Genetic background of posttraumatic stress disorder
- From genetics to epigenetics
- Epigenetic mechanisms in the process of stress-related disorders
- The influences of psychosocial stress on an epigenetic level.
- Epigenetic correlates of stress-reducing interventions and psychotherapies
- Conclusion
- References
- Chapter 10 PTSD and physiology: The long-term effects of PTSD and relation to epigenetics, physical health, and chronic dis...
- Introduction
- PTSD and adverse physical health
- Epigenetic studies of PTSD and implications for physical health
- EWAS of PTSD
- Comparing EWAS study characteristics
- Replicated findings
- EWAS results and implications for physical health
- Nervous system-related genes
- Inflammation and immune-related genes
- Endocrine-related genes
- Cardiovascular-related genes
- Metabolic disease-related genes
- Summary
- PTSD and epigenetic aging
- Summary
- Future directions
- Conclusions
- References
- Chapter 11 Epigenomic biomarkers of posttraumatic stress disorder
- Introduction
- Genetics of PTSD
- Epigenetics of PTSD
- DNA methylation
- Accelerated epigenetic aging and PTSD
- Histone modifications
- Noncoding RNAs
- Toward the development of PTSD multiomics biomarkers
- Gaps, challenges, and future directions
- Acknowledgments
- References
- Chapter 12 Adversity across time: Do sensitive periods across the life span determine adversity-induced epigenetic changes?
- Introduction
- Studies by timing of stress exposure
- Prenatal
- Postnatal to preadolescence (0-12 years old)
- Adolescence (12-20 years old)
- Adulthood ( >
- 20 years old)
- Intergenerational
- Methodological considerations
- Summary and concluding remarks
- Funding
- References
- Chapter 13 PTSD, telomeres, and aging
- Introduction
- Methods
- Results
- Kang et al. 24
- Kim et al. 25
- Avetyan et al. 27
- Connolly et al. 29
- Roberts et al. 30
- Bersani et al. 28
- Boks et al. 26
- Shalev et al. 31
- Zhang et al. 22
- Jergovi et al. 19
- Ladwig et al. 23
- O'Donovan et al. 21
- Malan et al. 20.
- Discussion
- References
- Chapter 14 Accelerated aging in mood disorders
- Introduction
- Mood disorders
- Major depressive disorder
- Bipolar disorder
- Clinical evidence of accelerated aging in mood disorders
- Major depressive disorder
- Bipolar disorder
- Pathophysiology of accelerated aging in mood disorders
- Biological clock findings in mood disorders
- Major depressive disorder
- Bipolar disorder
- Antiaging effects of antidepressants and mood stabilizers
- Conclusions
- References
- Chapter 15 Epigenetics, stress, and depression
- Introduction
- Materials and methods
- Results
- Chan et al. 5
- H|ls et al. 6
- Humphreys et al. 7
- Starnawska et al. 8
- Zhu et al. 9
- Bost�rm et al. 10
- Ciuculete et al. 11
- Kuan et al. 12
- Bustamante et al. 13
- Kaut et al. 14
- Dell'Osso et al. 15
- Davies et al. 16
- Weder et al. 17
- Melas et al. 18
- Numata et al. 19
- Discussion
- References
- Chapter 16 Capturing the epigenome: Differences among blood, saliva, and brain samples
- Introduction
- Early days of research on neuropsychiatric epigenetics in animals and humans
- Comparison of DNA methylation among blood, saliva, and buccal samples
- Salivary DNA methylation analyses
- Salivary DNA methylation studies of PTSD and trauma
- Studies on correlations between brain and peripheral tissue DNA methylation and its databases
- Conclusion
- References
- Chapter 17 Posttraumatic stress disorder, major depressive disorder, and noncoding RNAs
- Introduction
- Posttraumatic stress disorder
- Major depressive disorder
- MicroRNAs
- Long noncoding RNAs
- MicroRNA and posttraumatic stress disorder
- MicroRNAs and major depressive disorder
- Long noncoding RNAs and posttraumatic stress disorder
- Long noncoding RNAs and major depressie disorder.