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Imidazole-based drug discovery /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Agarwal, Shikha (Autor)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Amsterdam, Netherlands ; Oxford, United Kingdom ; Cambridge, MA, United States : Elsevier, [2022]
Colección:Heterocyclic drug discovery.
Temas:
Acceso en línea:Texto completo

MARC

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100 1 |a Agarwal, Shikha,  |e author. 
245 1 0 |a Imidazole-based drug discovery /  |c Shikha Agarwal. 
264 1 |a Amsterdam, Netherlands ;  |a Oxford, United Kingdom ;  |a Cambridge, MA, United States :  |b Elsevier,  |c [2022] 
264 4 |c �2022 
300 |a 1 online resource (xix, 351 pages) :  |b illustrations. 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
490 1 |a Heterocyclic drug discovery series 
504 |a Includes bibliographical references and index. 
505 8 |6 880-01  |a 2.3.5 Using benzil, aldehyde, and ammonium acetate -- 2.4 Tetra-substituted imidazole derivatives -- 2.4.1 Using aminoethylpiperazine -- 2.4.2 Using prop-2-ynylamine -- 2.4.3 Using benzil, aldehydes, ammonium acetate, and aniline -- 3 Imidazole hybrids -- 3.1 Imidazole fused heterocycles -- 3.2 Benzimidazole fused heterocycles -- 4 Benzimidazole -- 4.1 Hoebrecker synthesis -- 4.2 Synthesis of benzimidazoles using o -phenylenediamine and acids -- 4.3 Synthesis of benzimidazoles using o -phenylenediamine and acid anhydride -- 4.4 Synthesis of benzimidazoles using o -phenylenediamine and alcohols 
505 8 |a 4.5 Synthesis of benzimidazoles using o -phenylenediamine and alkyl halides -- 4.6 Synthesis of benzimidazoles using ketones -- 4.7 Synthesis of benzimidazoles using o -phenylenediamine and aldehydes -- 5 Conclusion -- Conflict of interest -- Acknowledgments -- Funding source -- References -- Chapter 2 Biological profile of imidazole-based compounds as anticancer agents -- 1 Introduction -- 2 Imidazole-based heterocycles -- 2.1 Imidazole as the main nucleus in the anticancer compounds -- 2.1.1 Mono-substituted imidazole derivatives -- 2.1.2 Disubstituted imidazole derivatives 
505 8 |a 2.1.3 Trisubstituted imidazole derivatives -- 2.1.4 Tetra-substituted imidazole derivatives -- 2.2 Imidazole hybrids as anticancer agents -- 2.3 Imidazole fused heterocycles -- 2.3.1 Imidazole fused heterocycles -- 2.3.2 Benzimidazole fused heterocycles -- 2.4 Imidazole-based metal complexes as anticancer agents -- 3 Conclusion and future challenges -- Conflict of interest -- Acknowledgment -- Funding source -- References -- Chapter 3 Recent advancements on imidazole containing heterocycles as antitubercular agents -- 1 Introduction -- 2 Imidazole-based heterocycles -- 2.1 Substituted imidazoles 
505 8 |a 2.2 Hybrid Imidazoles -- 2.3 Fused imidazoles -- 2.4 Linker imidazole -- 2.5 Benzimidazole -- 3 Conclusion -- Conflict of interest -- Acknowledgments -- Funding source -- References -- Chapter 4 Imidazole derivatives: Impact and prospects in antiviral drug discovery -- 1 Introduction -- 2 Imidazole derivatives and their action against different viruses -- 2.1 Zika virus -- 2.2 Influenza -- 2.3 SARS-COVID -- 2.4 Dengue -- 2.5 Hepatitis -- 2.6 HIV -- 2.7 Miscellaneous -- 3 Conclusion -- Acknowledgments -- Conflict of interest -- Funding source -- References 
500 |a Chapter 5 Imidazole heterocycles: Therapeutically potent lead compounds as antimicrobials. 
588 0 |a Online resource; title from PDF title page (ScienceDirect platform, viewed April 19, 2022). 
650 0 |a Imidazoles. 
650 0 |a Drugs. 
650 0 |a Drug development. 
650 2 |a Imidazoles  |0 (DNLM)D007093 
650 2 |a Pharmaceutical Preparations  |0 (DNLM)D004364 
650 6 |a Imidazole.  |0 (CaQQLa)201-0026559 
650 6 |a M�edicaments.  |0 (CaQQLa)201-0002990 
650 6 |a M�edicaments  |x D�eveloppement.  |0 (CaQQLa)201-0306620 
650 7 |a Drug development  |2 fast  |0 (OCoLC)fst00898670 
650 7 |a Drugs  |2 fast  |0 (OCoLC)fst00898761 
650 7 |a Imidazoles  |2 fast  |0 (OCoLC)fst01715755 
776 0 8 |i Print version:  |z 0323854796  |w (OCoLC)1257403690 
830 0 |a Heterocyclic drug discovery. 
856 4 0 |u https://sciencedirect.uam.elogim.com/science/book/9780323854795  |z Texto completo 
880 0 |6 505-01/(S  |a Intro -- Imidazole-Based Drug Discovery -- Copyright -- Dedication -- Contents -- Contributors -- About the authors -- Preface -- Acknowledgments -- Chapter 1 Imidazole and its derivatives: Introduction and synthetic aspects -- 1 Introduction -- 2 Synthesis of substituted imidazoles -- 2.1 Mono-substituted imidazole derivatives -- 2.2 Di-substituted imidazole derivatives -- 2.3 Tri-substituted imidazole derivatives -- 2.3.1 Using 2,3-diaminomaleonitrile -- 2.3.2 Using the Van Leusen method -- 2.3.3 Using 2,3-dioxo-3-substituted propanoates -- 2.3.4 Using α -aminoketones