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| LEADER |
00000cam a2200000 a 4500 |
| 001 |
SCIDIR_on1281957819 |
| 003 |
OCoLC |
| 005 |
20231120010613.0 |
| 006 |
m o d |
| 007 |
cr un|---aucuu |
| 008 |
211030s2021 cau o 000 0 eng d |
| 040 |
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|a EBLCP
|b eng
|e pn
|c EBLCP
|d YDX
|d OPELS
|d OCLCF
|d N$T
|d OCLCO
|d OCLCQ
|d OCLCO
|d K6U
|d OCLCQ
|d SFB
|d OCLCQ
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| 019 |
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|a 1280389859
|a 1280461216
|a 1280603410
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| 020 |
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|a 012821435X
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| 020 |
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|a 9780128214350
|q (electronic bk.)
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| 020 |
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|z 9780128214336
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| 020 |
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|z 0128214333
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| 035 |
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|a (OCoLC)1281957819
|z (OCoLC)1280389859
|z (OCoLC)1280461216
|z (OCoLC)1280603410
|
| 050 |
|
4 |
|a QP551
|
| 082 |
0 |
4 |
|a 572.6
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| 100 |
1 |
|
|a Yao, Xudong.
|
| 245 |
1 |
0 |
|a Advances in chemical proteomics
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| 260 |
|
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|a San Diego :
|b Elsevier,
|c 2021.
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| 300 |
|
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|a 1 online resource (270 pages)
|
| 336 |
|
|
|a text
|b txt
|2 rdacontent
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| 337 |
|
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a Developments in Organic Chemistry Ser.
|
| 505 |
0 |
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|a Front Cover -- ADVANCES IN CHEMICAL PROTEOMICS -- ADVANCES IN CHEMICAL PROTEOMICS -- Copyright -- Contents -- Contributors -- Biography -- 1 -- Concepts and principles -- 1 -- Introduction to proteomics for chemical biology -- 1.1 Multi-omics as a promising path to precision healthcare -- 1.2 The bottom-up proteomics workflow -- 1.2.1 Overview of proteomics -- 1.2.2 Sample preparation -- 1.2.2.1 Cell lysis -- 1.2.2.2 Total protein quantitation assay -- 1.2.2.3 Size-exclusion chromatography -- 1.2.2.4 Gel electrophoresis -- 1.2.2.5 Affinity capture -- 1.2.2.6 Protein digestion
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| 505 |
8 |
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|a 1.2.2.7 Offline peptide fractionation -- 1.2.3 Liquid chromatography -- 1.2.4 Mass spectrometry instrumentation and implementation in proteomics -- 1.2.4.1 Ion sources -- 1.2.4.2 Mass analyzers -- 1.2.4.3 Gas-phase peptide fragmentation and tandem mass spectrometry -- 1.2.4.4 Modes of spectral data acquisition in bottom-up proteomics -- 1.2.5 Bioinformatics of database search and peptide identification -- 1.2.5.1 Input pre-processing -- 1.2.5.2 In silico protein digestion -- 1.2.5.3 Peptide mass filtering -- 1.2.5.4 Peptide-spectrum matching and scoring
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| 505 |
8 |
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|a 1.3 Tools and strategies in chemical proteomics -- 1.3.1 Compound-centric versus activity-based probes -- 1.3.2 Chemical tagging on peptides -- 1.3.3 Metabolic labeling on proteins -- 1.4 Challenges and opportunities in chemical proteomics -- 1.4.1 Alternative bio-orthogonal affinity tags and trypsin-resistant affinity binders -- 1.4.2 Reactivity and selectivity of chemical probes -- 1.4.3 Bioinformatics for modification-specific proteomics -- 1.5 Conclusion -- References -- 2 -- Warheads for designing covalent inhibitors and chemical probes -- 2.1 Definitions -- 2.2 Foundational knowledge
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| 505 |
8 |
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|a 2.3 Recent developments -- 2.4 Points of view/opinions -- 2.4.1 Strategic considerations for the selection and optimization of the warheads -- 2.5 Summary and outlook -- References -- 3 -- Chemical derivatization of peptides for quantitative proteomics -- 3.1 Introduction -- 3.2 Quantitative proteomics concepts -- 3.2.1 Quantification methods -- 3.2.2 Data acquisition strategies -- 3.3 Labeling techniques for MS1-based quantification -- 3.3.1 General considerations -- 3.3.2 Isotope-coded affinity tag -- 3.3.3 Reductive dimethylation -- 3.3.4 Other MS1-based isotope labeling methods
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| 505 |
8 |
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|a 3.3.5 Labeling methods that do not use isotopic labeling -- 3.4 Labeling techniques for MS2- and MS3-based quantification -- 3.4.1 General considerations -- 3.4.2 Tandem Mass Tags -- 3.4.3 iTRAQ -- 3.4.4 Other isobaric tagging concepts based on reporter ion quantification -- 3.4.5 Quantification based on isobaric tagging and complementary fragment ions -- 3.4.6 Use of isobaric tags for sample amplification: application to single-cell proteomics -- 3.5 Achieving higher-order multiplexing by combining labeling strategies -- 3.6 Summary and outlook -- References
|
| 505 |
8 |
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|a 4 -- Open search algorithms discover patterns of chemical modifications via LC-MS/MS
|
| 588 |
0 |
|
|a Print version record.
|
| 650 |
|
0 |
|a Proteomics.
|
| 650 |
|
0 |
|a Biochemistry.
|
| 650 |
|
0 |
|a Chemistry, Organic.
|
| 650 |
|
2 |
|a Proteomics
|0 (DNLM)D040901
|
| 650 |
|
2 |
|a Biochemistry
|0 (DNLM)D001671
|
| 650 |
|
2 |
|a Chemistry, Organic
|0 (DNLM)D002625
|
| 650 |
|
6 |
|a Prot�eomique.
|0 (CaQQLa)201-0363192
|
| 650 |
|
6 |
|a Biochimie.
|0 (CaQQLa)201-0001077
|
| 650 |
|
6 |
|a Chimie organique.
|0 (CaQQLa)201-0004956
|
| 650 |
|
7 |
|a biochemistry.
|2 aat
|0 (CStmoGRI)aat300054538
|
| 650 |
|
7 |
|a organic chemistry.
|2 aat
|0 (CStmoGRI)aat300054541
|
| 650 |
|
7 |
|a Biochemistry
|2 fast
|0 (OCoLC)fst00831961
|
| 650 |
|
7 |
|a Chemistry, Organic
|2 fast
|0 (OCoLC)fst00853501
|
| 650 |
|
7 |
|a Proteomics
|2 fast
|0 (OCoLC)fst01079785
|
| 776 |
0 |
8 |
|i Print version:
|a Yao, Xudong.
|t Advances in Chemical Proteomics.
|d San Diego : Elsevier, �2021
|z 9780128214336
|
| 830 |
|
0 |
|a Developments in Organic Chemistry.
|
| 856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/book/9780128214336
|z Texto completo
|
