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Coeliac disease and gluten-related disorders /

Coeliac Disease and Gluten-Related Disorders provides an updated and comprehensive overview on the crucial aspects and clinical management of gluten-related disorders. It provides an overview of the scientific background, mechanisms involved, and emphasizes the translational effect of research on cl...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Schiepatti, Annalisa (Editor ), Sanders, David S. (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: London, United Kingdom : Academic Press, [2022]
Temas:
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Front cover
  • Half title
  • Title
  • Copyright
  • Contents
  • Contributors
  • Chapter 1 Epidemiology and clinical features of celiac disease in adults
  • 1.1 Introduction
  • 1.2 Initial epidemiological studies based on clinical symptoms
  • 1.3 Modern epidemiological study based on the serological test
  • 1.4 Global prevalence of CeD
  • 1.5 Global seroprevalence of CeD
  • 1.6 Global prevalence of biopsy-confirmed CeD
  • 1.7 Prevalence of CeD by gender and age
  • 1.8 Continent wise prevalence of CeD
  • 1.8.1 CeD in Europe
  • 1.8.2 Celiac disease in America (North and South America)
  • 1.8.3 Prevalence of CeD in Oceania
  • 1.8.4 Prevalence of CeD in Africa
  • 1.8.5 Prevalence of CeD in Asia
  • 1.8.6 Increase in the global prevalence of CeD over time
  • 1.8.7 Increase in the incidence of CeD
  • 1.8.8 Spectrum of clinical manifestations of CeD
  • 1.8.9 Gastrointestinal manifestations (Classical CeD)
  • 1.9 Extra-intestinal manifestations of CeD (Table 1.2 and Table 1.3)
  • 1.9.1 Hematological manifestations
  • 1.9.2 Endocrinological manifestations
  • 1.9.3 Skeletal manifestations (osteopenia and osteoporosis)
  • 1.9.4 Hepatic manifestations
  • 1.9.5 Metabolic manifestations
  • 1.9.6 Dermatological manifestations
  • 1.9.7 Reproductive manifestations
  • 1.9.8 Neuropsychiatric manifestations
  • 1.9.9 Oral cavity and dental manifestations
  • 1.10 Mortality in celiac disease
  • References
  • Chapter 2 Pediatric coeliac disease
  • 2.1 Introduction: Distinct features of pediatric coeliac disease
  • 2.2 Clinical presentation
  • 2.3 Diagnosis
  • 2.4 Screening of children for coeliac disease
  • 2.5 Treatment and monitoring of paediatric coeliac disease
  • 2.6 Toward primary prevention of coeliac disease?
  • 2.7 Summary
  • References
  • Chapter 3 Pathogenesis of coeliac disease
  • a disorder driven by gluten-specific CD4+ T cells.
  • 3.1 Inductive and effector sites within the gut immune system
  • 3.2 Induction of adaptive immune response to gluten
  • 3.2.1 Involvement HLA II molecules
  • 3.2.2 Transglutaminase 2 in CeD
  • 3.2.3 Gluten: The driver of T-cell response
  • 3.2.4 Gluten trafficking from lumen to lamina propria
  • 3.2.5 Antigen presenting cells in the lamina propria presenting gluten
  • 3.3 Gluten-specific CD4+ T cells
  • 3.3.1 HLA-DQ:gluten tetramers
  • 3.3.2 TCR recognition of gluten
  • 3.3.3 Molecular mimicry between gluten T-cell epitopes and bacterial peptides
  • 3.4 Functional role of gluten-specific CD4+ T cells
  • 3.4.1 Phenotype of gluten-specific CD4+ T cells
  • 3.4.2 Cytokine production
  • 3.4.3 T cell and B cell interaction: Antibody production and T-cell clonal expansion
  • 3.4.4 CD4+ T-cell help to intraepithelial lymphocytes (IELs)
  • 3.4.5 Mechanisms underlying villous blunting in CeD
  • 3.5 Concluding remarks
  • References
  • Chapter 4 Seronegative villous atrophy
  • 4.1 Introduction
  • 4.2 Seronegative coeliac disease
  • 4.3 Immunomediated non-coeliac enteropathies
  • 4.3.1 Autoimmune enteropathy
  • 4.3.2 Enteropathy associated to common variable immunodeficiency
  • 4.3.3 Iatrogenic forms of villous atrophy
  • 4.4 Enteropathies due to infectious causes
  • 4.5 Lymphoproliferative disorders causing villous atrophy
  • 4.6 Villous atrophy due to inflammatory disorders
  • 4.7 Idiopathic villous atrophy
  • 4.8 Methodological approach to differential diagnosis and management of seronegative villous atrophy
  • 4.8.1 Principles of management of seronegative villous atrophy
  • 4.9 Conclusions
  • References
  • Chapter 5 Nonresponsive and complicated coeliac disease
  • 5.1 Introduction
  • 5.2 Dietary indiscretion and mucosal healing
  • 5.3 An alternative pathology
  • 5.4 Refractory coeliac disease
  • 5.4.1 Treatment in refractory coeliac disease.
  • 8.1.1 Prevalence and incidence of dermatitis herpetiformis
  • 8.1.2 Gender and age at onset in dermatitis herpetiformis
  • 8.2 Pathogenesis of dermatitis herpetiformis: from gut to skin
  • 8.3 Clinical features of dermatitis herpetiformis
  • 8.4 Diagnosis of dermatitis herpetiformis
  • 8.4.1 Skin and small bowel biopsy findings
  • 8.4.2 Serum coeliac antibody measurements
  • 8.4.3 Diagnostic work-up of dermatitis herpetiformis
  • 8.5 Treatment of dermatitis herpetiformis
  • 8.5.1 Gluten-free diet
  • 8.5.2 Dapsone
  • 8.6 Long-term prognosis of dermatitis herpetiformis
  • 8.7 Concluding remarks
  • References
  • Chapter 9 Noncoeliac gluten sensitivity
  • 9.1 Introduction
  • 9.2 The clinical picture
  • 9.3 IBS
  • NCGS
  • or both?What can be learned from RCTs?
  • 9.4 The gluten-free market
  • 9.5 Immunobiology of gluten in NCGS (and CD)
  • 9.6 The possible culprits
  • 9.7 Serological and genetic markers
  • 9.8 Clinical investigation
  • the view of the clinical dietician
  • 9.9 The FODMAP approach
  • 9.10 Summary
  • References
  • Chapter 10 Pediatric noncoeliac gluten sensitivity
  • 10.1 Introduction
  • 10.2 Definition and epidemiology of NCGS/NCWS in children
  • 10.3 Clinical features and diagnosis of NCGS/NCWS in children
  • 10.3.1 Clinical features in adults and children
  • 10.3.2 Diagnosis of NCGS/NCWS
  • 10.3.3 Serological features of NCGS/NCWS in children
  • 10.4 Histological features of NCGS/NCWS in children
  • 10.5 Therapeutic approach to NCGS/NCWS in children
  • 10.6 Conclusion
  • References
  • Chapter 11 Neurological manifestations of gluten-related disorders
  • 11.1 Introduction
  • 11.2 Gluten ataxia
  • 11.3 Gluten neuropathy
  • 11.4 Gluten encephalopathy
  • 11.5 Epilepsy
  • 11.6 Gluten myopathy
  • 11.7 Pathophysiology
  • 11.8 Conclusions
  • References.
  • Chapter 12 The role of gluten in multiple sclerosis, psoriasis, autoimmune thyroid diseases and type 1 diabetes
  • 12.1 Introduction
  • 12.2 Gluten
  • 12.3 Multiple sclerosis
  • 12.3.1 Celiac disease and multiple sclerosis
  • 12.3.2 Can patients with multiple sclerosis benefit from a gluten-free diet?
  • 12.4 Psoriasis
  • 12.4.1 Celiac disease and psoriasis
  • 12.4.2 Gluten-related antibodies as markers of disease activity in psoriasis
  • 12.4.3 Can gluten intake affect the risk of psoriasis?
  • 12.4.4 Can patients with psoriasis benefit from a gluten-free diet?
  • 12.5 Autoimmune thyroid diseases
  • 12.5.1 Celiac disease and autoimmune thyroid diseases
  • 12.5.2 Gluten-related antibodies as markers of disease activity in autoimmune thyroid diseases
  • 12.5.3 Can patients with autoimmune thyroid diseases benefit from a gluten-free diet?
  • 12.6 Type 1 diabetes
  • 12.6.1 Celiac disease and type 1 diabetes
  • 12.6.2 Can gluten intake affect the risk of Type 1 Diabetes?
  • 12.6.3 Can patients with type 1 diabetes benefit from a gluten-free diet?
  • 12.7 Concluding remarks
  • References
  • Chapter 13 Irritable bowel syndrome
  • 13.1 Introduction
  • 13.2 Gluten free diet
  • 13.2.1 Nutritional adequacy
  • 13.2.2 Microbiota
  • 13.2.3 Wheat components
  • 13.2.4 Long term outcomes
  • 13.2.5 Adherence
  • 13.3 Low FODMAP diet
  • 13.3.1 Nutritional adequacy
  • 13.3.2 Microbiota
  • 13.3.3 Adherence
  • 13.3.4 Efficacy versus other dietary and nondietary therapies
  • 13.4 Traditional dietary advice
  • 13.5 Challenges of dietary studies
  • 13.6 Choice of dietary therapy
  • 13.7 Conclusion
  • References
  • Index
  • Back cover.