Coeliac disease and gluten-related disorders /
Coeliac Disease and Gluten-Related Disorders provides an updated and comprehensive overview on the crucial aspects and clinical management of gluten-related disorders. It provides an overview of the scientific background, mechanisms involved, and emphasizes the translational effect of research on cl...
Clasificación: | Libro Electrónico |
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Otros Autores: | , |
Formato: | Electrónico eBook |
Idioma: | Inglés |
Publicado: |
London, United Kingdom :
Academic Press,
[2022]
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Temas: | |
Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front cover
- Half title
- Title
- Copyright
- Contents
- Contributors
- Chapter 1 Epidemiology and clinical features of celiac disease in adults
- 1.1 Introduction
- 1.2 Initial epidemiological studies based on clinical symptoms
- 1.3 Modern epidemiological study based on the serological test
- 1.4 Global prevalence of CeD
- 1.5 Global seroprevalence of CeD
- 1.6 Global prevalence of biopsy-confirmed CeD
- 1.7 Prevalence of CeD by gender and age
- 1.8 Continent wise prevalence of CeD
- 1.8.1 CeD in Europe
- 1.8.2 Celiac disease in America (North and South America)
- 1.8.3 Prevalence of CeD in Oceania
- 1.8.4 Prevalence of CeD in Africa
- 1.8.5 Prevalence of CeD in Asia
- 1.8.6 Increase in the global prevalence of CeD over time
- 1.8.7 Increase in the incidence of CeD
- 1.8.8 Spectrum of clinical manifestations of CeD
- 1.8.9 Gastrointestinal manifestations (Classical CeD)
- 1.9 Extra-intestinal manifestations of CeD (Table 1.2 and Table 1.3)
- 1.9.1 Hematological manifestations
- 1.9.2 Endocrinological manifestations
- 1.9.3 Skeletal manifestations (osteopenia and osteoporosis)
- 1.9.4 Hepatic manifestations
- 1.9.5 Metabolic manifestations
- 1.9.6 Dermatological manifestations
- 1.9.7 Reproductive manifestations
- 1.9.8 Neuropsychiatric manifestations
- 1.9.9 Oral cavity and dental manifestations
- 1.10 Mortality in celiac disease
- References
- Chapter 2 Pediatric coeliac disease
- 2.1 Introduction: Distinct features of pediatric coeliac disease
- 2.2 Clinical presentation
- 2.3 Diagnosis
- 2.4 Screening of children for coeliac disease
- 2.5 Treatment and monitoring of paediatric coeliac disease
- 2.6 Toward primary prevention of coeliac disease?
- 2.7 Summary
- References
- Chapter 3 Pathogenesis of coeliac disease
- a disorder driven by gluten-specific CD4+ T cells.
- 3.1 Inductive and effector sites within the gut immune system
- 3.2 Induction of adaptive immune response to gluten
- 3.2.1 Involvement HLA II molecules
- 3.2.2 Transglutaminase 2 in CeD
- 3.2.3 Gluten: The driver of T-cell response
- 3.2.4 Gluten trafficking from lumen to lamina propria
- 3.2.5 Antigen presenting cells in the lamina propria presenting gluten
- 3.3 Gluten-specific CD4+ T cells
- 3.3.1 HLA-DQ:gluten tetramers
- 3.3.2 TCR recognition of gluten
- 3.3.3 Molecular mimicry between gluten T-cell epitopes and bacterial peptides
- 3.4 Functional role of gluten-specific CD4+ T cells
- 3.4.1 Phenotype of gluten-specific CD4+ T cells
- 3.4.2 Cytokine production
- 3.4.3 T cell and B cell interaction: Antibody production and T-cell clonal expansion
- 3.4.4 CD4+ T-cell help to intraepithelial lymphocytes (IELs)
- 3.4.5 Mechanisms underlying villous blunting in CeD
- 3.5 Concluding remarks
- References
- Chapter 4 Seronegative villous atrophy
- 4.1 Introduction
- 4.2 Seronegative coeliac disease
- 4.3 Immunomediated non-coeliac enteropathies
- 4.3.1 Autoimmune enteropathy
- 4.3.2 Enteropathy associated to common variable immunodeficiency
- 4.3.3 Iatrogenic forms of villous atrophy
- 4.4 Enteropathies due to infectious causes
- 4.5 Lymphoproliferative disorders causing villous atrophy
- 4.6 Villous atrophy due to inflammatory disorders
- 4.7 Idiopathic villous atrophy
- 4.8 Methodological approach to differential diagnosis and management of seronegative villous atrophy
- 4.8.1 Principles of management of seronegative villous atrophy
- 4.9 Conclusions
- References
- Chapter 5 Nonresponsive and complicated coeliac disease
- 5.1 Introduction
- 5.2 Dietary indiscretion and mucosal healing
- 5.3 An alternative pathology
- 5.4 Refractory coeliac disease
- 5.4.1 Treatment in refractory coeliac disease.
- 8.1.1 Prevalence and incidence of dermatitis herpetiformis
- 8.1.2 Gender and age at onset in dermatitis herpetiformis
- 8.2 Pathogenesis of dermatitis herpetiformis: from gut to skin
- 8.3 Clinical features of dermatitis herpetiformis
- 8.4 Diagnosis of dermatitis herpetiformis
- 8.4.1 Skin and small bowel biopsy findings
- 8.4.2 Serum coeliac antibody measurements
- 8.4.3 Diagnostic work-up of dermatitis herpetiformis
- 8.5 Treatment of dermatitis herpetiformis
- 8.5.1 Gluten-free diet
- 8.5.2 Dapsone
- 8.6 Long-term prognosis of dermatitis herpetiformis
- 8.7 Concluding remarks
- References
- Chapter 9 Noncoeliac gluten sensitivity
- 9.1 Introduction
- 9.2 The clinical picture
- 9.3 IBS
- NCGS
- or both?What can be learned from RCTs?
- 9.4 The gluten-free market
- 9.5 Immunobiology of gluten in NCGS (and CD)
- 9.6 The possible culprits
- 9.7 Serological and genetic markers
- 9.8 Clinical investigation
- the view of the clinical dietician
- 9.9 The FODMAP approach
- 9.10 Summary
- References
- Chapter 10 Pediatric noncoeliac gluten sensitivity
- 10.1 Introduction
- 10.2 Definition and epidemiology of NCGS/NCWS in children
- 10.3 Clinical features and diagnosis of NCGS/NCWS in children
- 10.3.1 Clinical features in adults and children
- 10.3.2 Diagnosis of NCGS/NCWS
- 10.3.3 Serological features of NCGS/NCWS in children
- 10.4 Histological features of NCGS/NCWS in children
- 10.5 Therapeutic approach to NCGS/NCWS in children
- 10.6 Conclusion
- References
- Chapter 11 Neurological manifestations of gluten-related disorders
- 11.1 Introduction
- 11.2 Gluten ataxia
- 11.3 Gluten neuropathy
- 11.4 Gluten encephalopathy
- 11.5 Epilepsy
- 11.6 Gluten myopathy
- 11.7 Pathophysiology
- 11.8 Conclusions
- References.
- Chapter 12 The role of gluten in multiple sclerosis, psoriasis, autoimmune thyroid diseases and type 1 diabetes
- 12.1 Introduction
- 12.2 Gluten
- 12.3 Multiple sclerosis
- 12.3.1 Celiac disease and multiple sclerosis
- 12.3.2 Can patients with multiple sclerosis benefit from a gluten-free diet?
- 12.4 Psoriasis
- 12.4.1 Celiac disease and psoriasis
- 12.4.2 Gluten-related antibodies as markers of disease activity in psoriasis
- 12.4.3 Can gluten intake affect the risk of psoriasis?
- 12.4.4 Can patients with psoriasis benefit from a gluten-free diet?
- 12.5 Autoimmune thyroid diseases
- 12.5.1 Celiac disease and autoimmune thyroid diseases
- 12.5.2 Gluten-related antibodies as markers of disease activity in autoimmune thyroid diseases
- 12.5.3 Can patients with autoimmune thyroid diseases benefit from a gluten-free diet?
- 12.6 Type 1 diabetes
- 12.6.1 Celiac disease and type 1 diabetes
- 12.6.2 Can gluten intake affect the risk of Type 1 Diabetes?
- 12.6.3 Can patients with type 1 diabetes benefit from a gluten-free diet?
- 12.7 Concluding remarks
- References
- Chapter 13 Irritable bowel syndrome
- 13.1 Introduction
- 13.2 Gluten free diet
- 13.2.1 Nutritional adequacy
- 13.2.2 Microbiota
- 13.2.3 Wheat components
- 13.2.4 Long term outcomes
- 13.2.5 Adherence
- 13.3 Low FODMAP diet
- 13.3.1 Nutritional adequacy
- 13.3.2 Microbiota
- 13.3.3 Adherence
- 13.3.4 Efficacy versus other dietary and nondietary therapies
- 13.4 Traditional dietary advice
- 13.5 Challenges of dietary studies
- 13.6 Choice of dietary therapy
- 13.7 Conclusion
- References
- Index
- Back cover.