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Medical epigenetics /
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London, United Kingdom :
Academic Press,
2021.
|
| Edición: | Second edition. |
| Colección: | Translational epigenetics series ;
v. 29. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Intro
- Medical Epigenetics
- Copyright
- Contents
- Contributors
- Preface
- Section A Overview
- Chapter 1 Advances in medical epigenetics
- Introduction
- Basic principles of epigenetics
- General medical aspects of epigenetics
- Epigenetics of system disorders
- Multisystem medical epigenetics
- Bioinformatics of epigenetic medicine
- Pharmacology of epigenetics
- Therapeutic epigenetics
- Medical epigenetics: Future prospects
- Conclusion
- References
- Section B General medical aspects of epigenetics
- Chapter 2 Environmental epigenetic epidemiology
- Introduction
- Malnutrition
- Environmental pollutants
- Air pollution
- Endocrine-disrupting chemicals
- Heavy metals
- Substance abuse
- Alcohol
- Tobacco smoking
- Marijuana smoking
- Opioids
- Infection
- Conclusions and perspectives
- Acknowledgment
- References
- Chapter 3 Lifestyle and preventive medical epigenetics
- Introduction
- Epigenetics
- How epigenetics influence risk of diseases
- How lifestyle determines epigenetics
- How knowledge on epigenetics could be used to prevent diseases
- Impact of dietary pattern on the epigenome
- Carbohydrates and epigenetic modifications
- Proteins and epigenetic modifications
- Fatty acids and epigenetic modifications
- Role of micronutrients in epigenetics
- Essential vitamins
- Mineral elements
- Bioactive compounds
- Exercise and epigenetics
- Environmental factors and epigenetic modification
- Lifestyle modification as a preventive tool for medical epigenetics
- Conclusion
- References
- Chapter 4 Environmental medical epigenetics: A review of epigenetically induced medical risks generated from exposures in our air, f ...
- Introduction
- Allergens
- Aeroallergens
- Food allergens
- Secondhand cigarette smoke and vaping
- Traffic-related air pollution
- PM 2.5.
- Diesel exhaust particles
- Polycyclic aromatic hydrocarbons
- Trace metals
- Heavy metals
- Chromium
- Arsenic
- Lead
- Cadmium
- Endocrine-disrupting chemicals
- Bisphenol A
- Phthalates
- Parabens
- Flame retardants/polybrominated diphenyl ethers
- Pesticides and fungicides
- Vinclozolin
- Persistent organic pollutants and other pesticides
- Volatile organic compounds
- Farm exposure
- Diet
- Folic acid and other methyl donors
- Additional vitamin and antioxidant supplementation
- Dietary fat, sucrose
- Famine
- Conclusions/outstanding questions
- Glossary
- References
- Chapter 5 Behavioral medical epigenetics
- Introduction
- Impact of environmental factors on behavior
- Animal models and studies of human behavior
- Environmental stressors and epigenetic mediators of the stress response
- Nonepigenetic and alternate mechanisms of stress
- The HPA axis and the stress response
- Glucocorticoid signaling and epigenetics
- HPA axis genes: Genes that regulate glucocorticoid signaling
- Chronic stress and glucocorticoid resistance
- Glucocorticoid resistance and epigenetics
- HPA axis genes: Genes that regulate tissue-specific processes
- Environmental stressors and neurotransmitters
- Interconnectivity of the neurotransmitter systems
- The dopaminergic system
- Behavioral disorders associated with the dopaminergic system
- Evidence for glucocorticoid effect on dopaminergic transmission
- Glucocorticoids and dopamine in drug addiction
- Epigenetic mediators of glucocorticoids on dopamine-related behavior
- Adrenergic and noradrenergic systems
- Behavioral disorders associated with the adrenergic and noradrenergic system
- Evidence for glucocorticoid effect on adrenergic and noradrenergic transmission
- Epigenetic mediators of glucocorticoids on adrenaline- and noradrenaline-related behavior.
- The serotonergic (5-HT) system
- Behavioral disorders associated with the serotonergic system
- Evidence for glucocorticoid effect on serotonergic transmission
- Epigenetic mediators of glucocorticoids on serotonin-related behavior
- Glutamate and GABA systems
- Behavioral disorders associated with the glutamate and GABA system
- Evidence for glucocorticoid effect on glutamate and GABA system
- Epigenetic mediators of glucocorticoids on glutamate and GABA-related behavior
- Conclusion
- References
- Chapter 6 Medical epigenetics and twins
- Introduction
- Monogenic disorders: Twin studies and the epigenetics of imprinting disorders
- Twin studies and Beckwith-Wiedemann syndrome
- Twin studies and Silver-Russell syndrome
- Twin studies and the epigenetics of multifactorial disorders
- Twin studies and the epigenetics of cardiovascular diseases
- Twin studies and the epigenetics of psychiatric disorders
- Twin studies and the epigenetics of autism
- Twin studies and the epigenetics of schizophrenia
- Twin studies and the epigenetics of depression
- Twin studies and the epigenetics of aging
- Twin studies and the epigenetics of metabolic traits and disease
- Body mass index
- Diabetes
- Twin studies and epigenetic mechanisms
- Rett syndrome
- Caveats
- Future directions
- Conclusions
- References
- Chapter 7 Epigenetic biomarkers of disease
- Introduction
- Epigenetic biomarkers
- Disruption of the "epigenetic machinery" in cancer
- Epigenetic mechanisms of acquired drug resistance
- Types of epigenetic modifications
- DNA methylation
- Noncoding RNAs (miRNAs)
- Histone modifications
- Chromatin remodeling
- Epigenetic biomarkers in cancer
- Diagnosis, prognosis, and drug response epigenetic biomarkers in solid biopsies
- Lung cancer
- Breast cancer
- Colorectal cancer
- Prostate cancer.
- Diagnosis, prognosis, and drug response biomarkers in liquid biopsies
- Lung cancer
- Breast cancer
- Colorectal cancer
- Prostate cancer
- Head and neck squamous cell carcinoma
- Pancreatic cancer
- Melanoma
- Hepatocellular carcinoma
- Methods for assessing epigenetic changes for biomarkers
- Genome-wide epigenetic analysis
- Enrichment-based methods
- Bisulfite conversion-based methods
- Specific methods for 5hmC
- miRNA genome-wide profiling
- Locus-specific epigenetic analysis
- Pyrosequencing
- Targeted next-generation sequencing
- Amplicon melting-based method
- RT-PCR based for 5mC and 5hmC targeted screening
- Specific methods for liquid biopsy
- Bioinformatic analysis
- Clinical application of epigenetic biomarkers
- Epigenetic biomarkers in precision medicine
- Epigenetic plasticity as a therapeutic target
- Epigenomic modulation drugs
- Future perspectives
- Conclusion
- References
- Chapter 8 Prognostic epigenetics
- Introduction
- DNA methylation markers of cancer prognosis
- Histone modifications as markers of cancer prognosis
- Noncoding RNA prognostic markers in cancer
- Prognostic epigenetic markers in nonmalignant pathology
- The future
- Conflict of interest statement
- References
- Section C Epigenetics of system disorders
- Chapter 9 Autoimmune disease and epigenetics
- Autoimmune disease overview
- Autoimmune disease etiology
- Epigenetics and autoimmunity
- Epigenetic regulation of T cell subset differentiation
- DNA methylation and autoimmune disease
- DNA hypomethylation
- DNA hypermethylation
- DNA hydroxymethylation
- Histone modifications and autoimmune disease
- Histone acetylation
- Histone methylation
- RNA modifications in autoimmune disease
- Environmental epigenetics
- Environmental epigenetics and autoimmunity
- Xenobiotics and autoimmunity.
- Mechanisms of xenobiotic-induced autoimmunity
- Xenobiotic-induced epigenetic changes and autoimmunity
- Trichloroethylene
- Trichloroethylene-mediated immunotoxicity
- Trichloroethylene and autoimmunity
- Trichloroethylene-induced autoimmunity in experimental models
- Trichloroethylene-mediated epigenetic changes in CD4 + T cells
- Conclusions
- References
- Chapter 10 Epigenetics of pulmonary diseases
- Introduction
- Epigenetic basics
- Epigenetics in disease
- Epigenetics in the lungs
- Epigenetics in pulmonary diseases
- Lung cancer
- Pulmonary hypertension
- Chronic obstructive pulmonary disease
- Idiopathic pulmonary fibrosis
- Tuberculosis
- Conclusion
- Grants
- Disclosures
- Author contributions
- References
- Chapter 11 Cardiovascular disorders and epigenetics
- Introduction
- Early heart development and the fetal origin of cardiovascular disease
- Epigenetic involvement in cardiovascular risk factors
- Smoking
- Age
- Hypertension
- Obesity and dyslipidemia
- Diabetes
- Epigenetics and cardiovascular disease
- Endothelial dysfunction and atherosclerosis
- Ischemic heart disease
- Stroke
- Vascular disease
- Cardiac hypertrophy
- Heart failure
- Epigenetic-based cardiovascular therapy
- Conclusion
- References
- Chapter 12 Epigenomics of intestinal disease
- Introduction
- Epigenetics and intestinal development
- Intestinal homeostasis and the microbiota
- Epigenetics, intestinal homeostasis, and the microbiota
- Microbiota-derived metabolites
- Diet and the intestinal epigenome
- Colon cancer
- Inflammatory bowel disease
- Irritable bowel syndrome
- Celiac disease
- Therapeutics
- Future directions
- Glossary
- Acknowledgments
- References
- Chapter 13 Epigenetics of skin disorders
- Immunologic skin diseases
- Introduction
- Epigenetics in systemic lupus erythematosus.