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|a 9780128193457
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|a Sex and gender differences in alzheimer's disease :
|b the women's brain project /
|c edited by Maria Teresa Ferretti, Annemarie Schumacher Dimech, Antonella Chadha Santuccione.
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|a London :
|b Academic Press,
|c 2021.
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|a 1 online resource
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|a Intro -- Sex and Gender Differences in Alzheimer's Disease: The Women's Brain Project -- Copyright -- Dedication -- Contents -- Contributors -- Acknowledgments -- Introduction -- Editors' biography -- Foreword -- Section 1: Sex differences in fundamental neurobiological processes that are relevant to Alzheimer's disease -- Chapter 1 Sex differences in Alzheimer's disease animal models -- Overview of Alzheimer's disease -- AD animal models -- Mutant APP mouse models -- Mouse models with multiple FAD mutations -- Mouse models of tau pathology -- Other AD mutant models -- Evidence for sex differences in AD animal models -- The triple transgenic AD mouse model: 3xTg-AD -- Age-dependent behavioral sex differences -- Sex differences in glucose homeostasis and immune function -- Olfaction and hormonal-related factors -- Lifespan -- APP and PSEN1 transgenic mouse models: TgCRND8, APPswe/PSEN1dE9, APPPS1, and PS2APP/Trem2KO -- ApoE transgenic mouse models: ApoE4/3xTg, 5xFAD/ApoE3, and 5xFAD/ApoE4 -- Tau mouse models: P301S, rTg4510, JNPL3 -- Nontransgenic animals -- Limitations -- Conclusion -- Chapter highlights -- References -- Chapter 2 Sex and sex hormone differences in hippocampal neurogenesis and their relevance to Alzheimer's disease -- Introduction -- Adult neurogenesis in the dentate gyrus -- The function of adult neurogenesis in the hippocampus -- Neurogenesis and aging -- Sex differences in neurogenesis -- Sex differences in neurogenesis in the context of cognitive training -- Alzheimer's disease -- Sex differences in Alzheimer's disease -- Animal models for Alzheimer's disease and sex differences -- Neurogenesis in Alzheimer's disease -- Neurogenesis in models of Alzheimer's disease -- Estrogens and aging -- Estrogens and neurogenesis -- Estrogens and neurogenesis in the context of aging -- Estrogens, aging, and cognition.
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|a Structural MRI -- Structural MRI sex differences in healthy subjects -- Structural MRI sex differences in dementia -- Conclusion -- Functional MRI -- fMRI sex differences in healthy subjects -- fMRI sex differences in dementia -- Conclusion -- Perfusion SPECT -- Perfusion SPECT sex differences in healthy subjects -- Perfusion SPECT sex differences in dementia -- Conclusion -- Dat Spect -- DAT SPECT sex differences in healthy subjects -- DAT SPECT sex differences in dementia -- Fdg-Pet -- FDG-PET sex differences in healthy subjects -- FDG-PET sex differences in dementia -- Amyloid PET -- Amyloid PET sex differences in healthy subjects -- Amyloid PET sex differences in dementia -- Conclusion -- Emerging PET modalities -- Tau PET sex differences in healthy subjects and dementia -- Neurotransmission PET sex differences in healthy subjects and dementia -- Neuroinflammation PET sex differences in healthy subjects and dementia -- Conclusion -- Chapter highlights -- References -- Chapter 6 Sex and gender differe nces in neuropsychological symptoms for clinical diagnosis of Alzheimer's disease -- Introduction -- Memory -- Introduction -- Sex/gender differences in verbal memory in healthy adults -- Sex/gender differences in verbal memory in mild cognitive impairment -- Sex/gender differences in verbal memory in AD -- Sex/gender differences and rates of verbal memory decline -- Summary -- Language -- Introduction -- Laterality, handedness, and connectivity of the language system -- Semantic dysfunction in neural disorders other than AD -- Critical semantic disruption in AD -- Executive function -- Introduction -- Sex/gender differences in executive function -- Sex/gender differences in cognitive reserve mechanisms -- Conclusion -- Chapter highlights -- Support -- References -- Chapter 7 Sex differences in psychiatric disorders and their implication for dementia.
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|a Psychiatric disorders matter as modifiable risk factors for dementia over the entire life span -- Major depression: A relevant modifiable risk factor for dementia with sex- and gender-related implications -- Social signal transduction theory of depression: A hypothesis to explain the female's increased vulnerability during child ... -- Late life versus earlier life depression and risk of developing dementia -- Depression or dementia? A key diagnostic challenge in the elderly -- Pharmacotherapy in the elderly: A major challenge with the risk of detrimental polypharmacy -- Antidepressants in dementia -- Polypharmacy -- Behavioral and psychological symptoms of dementia -- Treatment of BPSD: A key challenge in dementia care -- Benzodiazepines in the elderly -- Conclusion -- Chapter highlights -- References -- Chapter 8 Sleep disorders and dementia -- Why do we spend a third of life sleeping? An introduction to sleep and its main characteristics -- Sleep disorders and physiological sleep changes during aging -- Sex- and gender-related differences in sleep and sleep disorders -- Sleep disorders in Alzheimer's disease -- Sleep architecture in Alzheimer's disease -- Treating sleep disorders in Alzheimer's disease -- Sleep disorders and Alzheimer's disease: The caregiver's burden -- Key points -- Insomnia: An independent risk factor for cognitive impairment -- Treating sleep disorders in the elderly -- Key points -- Obstructive sleep apnea syndrome: A risk factor for cognitive impairment and Alzheimer's disease -- Obstructive sleep apnea syndrome and the different clinical pictures in male and female patients -- Obstructive sleep apnea syndrome in relation to cognitive impairment and Alzheimer's disease -- Biomarkers in OSAS and Alzheimer's disease -- Key points.
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|a REM sleep behavior disorder: A relevant parasomnia and an early clinical biomarker for neurodegenerative diseases -- REM sleep behavior disorder and sex- and gender-related differences -- REM sleep behavior disorder and the risk of clinical manifestation of a neurodegenerative disease -- Sundown syndrome in Alzheimer's disease is associated with RBD -- Key points -- Conclusion -- Chapter highlights -- References -- Chapter 9 Hormones and dementia -- Sex differences are hormone differences -- Hormones and cognition -- Estrogen -- Progesterone -- Testosterone and DHEA -- Menopause and cognition -- Natural menopause -- Surgical menopause -- Observational studies of hormone therapy use -- Interventional HT use -- Hormone therapy and cognition -- Hormone therapy in younger women -- The timing hypothesis -- Side-effect profile -- Hormones and cognition in men -- Gaps in knowledge -- The impact of hormones on known key risk factors for cognitive decline -- Vascular risk and disease (BMI, HT, lipids (APOE4)) -- Diabetes and impaired glucose tolerance -- Metabolic syndrome and inflammation -- Depression -- Sleep -- Midlife to late-life longitudinal prospective studies including hormone, cognitive, and neuropathological biomarkers -- Timing and therapeutic windows -- Information on all types of HT preparation -- Conclusion -- Chapter highlights -- References -- Chapter 10 Sex and gender differences in genetic and lifestyle risk and protective factors for dementia -- Introduction -- APOE allele -- Hormones, menopause, and andropause -- Hormone replacement therapy -- Reproductive history and timing of menopause -- Andropause -- Cardiometabolic risk factors -- Smoking and alcohol consumption -- Physical activity and exercise -- Nutrition -- Sleep disturbances -- Neural reserve and resilience -- Sex and gender dichotomies in cognitive aging research.
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|a Alzheimer's disease.
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|a Brain
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|a Women's health services.
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1 |
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|a Ferretti, Maria Teresa.
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1 |
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|a Dimech, Annemarie Schumacher.
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|a Santuccione, Antonella Chadha.
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|i Print version:
|z 0128193441
|z 9780128193440
|w (OCoLC)1201672970
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|u https://sciencedirect.uam.elogim.com/science/book/9780128193440
|z Texto completo
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