Genome editing : a practical guide to research and clinical applications /

"Genome Editing: A Practical Guide to Research and Clinical Applications is geared towards investigators interested in learning how to use CRISPR-Cas9-based technologies, with a focus on cardiovascular research and clinical applications. Covering a range of topics from the basics of genome edit...

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Bibliographic Details
Call Number:Libro Electrónico
Main Author: Musunuru, Kiran (Author)
Format: Electronic eBook
Language:Inglés
Published: London : Academic Press, 2021.
Subjects:
Gene editing.
CRISPR-associated protein 9.
CRISPR (Genetics)
Cardiovascular system > Diseases > Genetic aspects.
Gene Editing
CRISPR-Associated Protein 9
Clustered Regularly Interspaced Short Palindromic Repeats
�Edition g�enique.
Prot�eine-9 associ�ee �a CRISPR.
Appareil cardiovasculaire > Maladies > Aspect g�en�etique.
CRISPR (G�en�etique)
Cardiovascular system > Diseases > Genetic aspects
CRISPR-associated protein 9
Gene editing
Online Access:Texto completo
Table of Contents:
  • A brief history and primer on genome editing
  • Choosing a genome editing strategy and target site
  • Choosing a nuclease, guide RNA, and repair template
  • Assessing the outcomes of genome editing
  • Assessing for off-target mutagenesis
  • Base editing
  • Alternative types of editing
  • Genome editing for cellular disease modeling
  • Genome editing for functional experiments and screens
  • Therapeutic genome editing.

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