The stem cell niche during ageing /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Nilsson, Susie (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Cambridge, MA : Academic Press, 2020.
Edición:First edition.
Colección:Advances in stem cells and their niches ; volume 4.
Temas:
Stem cells.
Aging > Molecular aspects.
Aging.
Stem Cell Niche
Stem Cells
Aging
Cellules souches.
Vieillissement > Aspect mol�eculaire.
Vieillissement.
Aging > Molecular aspects
Stem cells
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • The Stem Cell Niche during Ageing
  • Copyright
  • Contents
  • Contributors
  • Chapter One: The aging hematopoietic stem cell niche
  • 1. Introduction
  • 2. Cellular components of the aged HSC niche
  • 2.1. Megakaryocytes (MK)
  • 2.2. OBL (osteoblastic lineage) cells
  • 2.3. Mesenchymal stromal cells (MSC)
  • 2.4. Adipocytes
  • 2.5. Endothelial cells
  • 2.6. Nervous system
  • 3. Extracellular components of the aged HSC niche
  • 3.1. Cytokines
  • 3.2. Extra-cellular matrix (ECM) molecules
  • 4. Other factors involved in the aged HSC phenotype
  • 4.1. Vitamins and dietary nutrients
  • 4.2. Metal ions
  • 4.3. Oxygen
  • 5. The human context
  • 6. Summary
  • Acknowledgments
  • Conflicts of interest
  • References
  • Chapter Two: Aging of intestinal stem cells and associated niche
  • 1. Introduction
  • 2. Intestinal stem cells and their associated niche
  • 2.1. Lgr5+ intestinal stem and progenitor cells
  • 2.2. Epithelial and mesenchymal niches
  • 3. Age-related alterations in the intestine
  • 3.1. Morphological and cellular alterations
  • 3.2. Age-mediated signaling alterations
  • 4. Strategies for restoring youthful function of aged intestinal stem cells
  • 4.1. Manipulating WNT signaling
  • 4.2. Restoring energy metabolism
  • 5. Conclusions
  • References
  • Chapter Three: The aging spermatogonial stem cell niche
  • 1. Introduction
  • 2. Spermatogonial stem cell niche
  • 2.1. Composition and characteristics
  • 2.2. Niche factors regulating SSC maintenance and spermatogenesis
  • 3. Aging of the spermatogonial stem cell niche
  • 3.1. Effects of aging on reproductive health
  • 3.2. Effects of an aging niche on SSC function
  • 3.2.1. Effects of aging on function of the SSC niche in rodents
  • 3.2.2. Insight into mechanisms of germline aging from Drosophila
  • 3.2.3. Intrinsic mechanisms underlying SSC failure during aging
  • 3.3. Paternal age effect mutations in humans
  • 4. Conclusions
  • References
  • Chapter Four: The aging epidermal skin niche
  • 1. Introduction
  • 2. Morphological organization of skin into discrete compartments
  • 3. Gross morphological changes in the epidermis and dermis that affect skin renewal with aging
  • 4. Epidermal dependency on microenvironmental signals from the dermis
  • 5. Intrinsic regulation of skin renewal: Epidermal stem and progenitor cell contributions
  • 6. Extrinsic regulation of skin renewal: Dermal mesenchymal contributions
  • 6.1. Dermal fibroblast heterogeneity
  • 6.2. Dermal pericytes in the epidermal niche
  • 6.3. Changes to ECM composition of the dermis with skin aging
  • 6.3.1. Changes to collagen composition in aged skin
  • 6.3.2. Changes to dermal proteoglycans and gycosaminoglycans in aging skin
  • 6.3.2.1. Hyaluronic acid
  • 6.3.2.2. Sulfated proteoglycans
  • 7. Conclusions
  • References

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