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|a The stem cell niche during ageing /
|c edited by Susie Nilsson.
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| 250 |
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|a First edition.
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| 264 |
|
1 |
|a Cambridge, MA :
|b Academic Press,
|c 2020.
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| 264 |
|
4 |
|c �2020
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| 300 |
|
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|a 1 online resource (x, 242 pages) :
|b illustrations (chiefly color)
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| 336 |
|
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
|
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a Advances in stem cells and their niches ;
|v volume 4
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| 504 |
|
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|a Includes bibliographical references.
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| 505 |
8 |
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|a Intro -- The Stem Cell Niche during Ageing -- Copyright -- Contents -- Contributors -- Chapter One: The aging hematopoietic stem cell niche -- 1. Introduction -- 2. Cellular components of the aged HSC niche -- 2.1. Megakaryocytes (MK) -- 2.2. OBL (osteoblastic lineage) cells -- 2.3. Mesenchymal stromal cells (MSC) -- 2.4. Adipocytes -- 2.5. Endothelial cells -- 2.6. Nervous system -- 3. Extracellular components of the aged HSC niche -- 3.1. Cytokines -- 3.2. Extra-cellular matrix (ECM) molecules -- 4. Other factors involved in the aged HSC phenotype -- 4.1. Vitamins and dietary nutrients
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| 505 |
8 |
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|a 4.2. Metal ions -- 4.3. Oxygen -- 5. The human context -- 6. Summary -- Acknowledgments -- Conflicts of interest -- References -- Chapter Two: Aging of intestinal stem cells and associated niche -- 1. Introduction -- 2. Intestinal stem cells and their associated niche -- 2.1. Lgr5+ intestinal stem and progenitor cells -- 2.2. Epithelial and mesenchymal niches -- 3. Age-related alterations in the intestine -- 3.1. Morphological and cellular alterations -- 3.2. Age-mediated signaling alterations -- 4. Strategies for restoring youthful function of aged intestinal stem cells
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| 505 |
8 |
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|a 4.1. Manipulating WNT signaling -- 4.2. Restoring energy metabolism -- 5. Conclusions -- References -- Chapter Three: The aging spermatogonial stem cell niche -- 1. Introduction -- 2. Spermatogonial stem cell niche -- 2.1. Composition and characteristics -- 2.2. Niche factors regulating SSC maintenance and spermatogenesis -- 3. Aging of the spermatogonial stem cell niche -- 3.1. Effects of aging on reproductive health -- 3.2. Effects of an aging niche on SSC function -- 3.2.1. Effects of aging on function of the SSC niche in rodents
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| 505 |
8 |
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|a 3.2.2. Insight into mechanisms of germline aging from Drosophila -- 3.2.3. Intrinsic mechanisms underlying SSC failure during aging -- 3.3. Paternal age effect mutations in humans -- 4. Conclusions -- References -- Chapter Four: The aging epidermal skin niche -- 1. Introduction -- 2. Morphological organization of skin into discrete compartments -- 3. Gross morphological changes in the epidermis and dermis that affect skin renewal with aging -- 4. Epidermal dependency on microenvironmental signals from the dermis
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| 505 |
8 |
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|a 5. Intrinsic regulation of skin renewal: Epidermal stem and progenitor cell contributions -- 6. Extrinsic regulation of skin renewal: Dermal mesenchymal contributions -- 6.1. Dermal fibroblast heterogeneity -- 6.2. Dermal pericytes in the epidermal niche -- 6.3. Changes to ECM composition of the dermis with skin aging -- 6.3.1. Changes to collagen composition in aged skin -- 6.3.2. Changes to dermal proteoglycans and gycosaminoglycans in aging skin -- 6.3.2.1. Hyaluronic acid -- 6.3.2.2. Sulfated proteoglycans -- 7. Conclusions -- References
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| 588 |
0 |
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|a Online resource; title from digital title page (viewed on September 22, 2020).
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| 650 |
|
0 |
|a Stem cells.
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| 650 |
|
0 |
|a Aging
|x Molecular aspects.
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| 650 |
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0 |
|a Aging.
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| 650 |
|
2 |
|a Stem Cell Niche
|0 (DNLM)D055153
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| 650 |
|
2 |
|a Stem Cells
|0 (DNLM)D013234
|
| 650 |
|
2 |
|a Aging
|0 (DNLM)D000375
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| 650 |
|
6 |
|a Cellules souches.
|0 (CaQQLa)201-0058821
|
| 650 |
|
6 |
|a Vieillissement
|x Aspect mol�eculaire.
|0 (CaQQLa)201-0203052
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| 650 |
|
6 |
|a Vieillissement.
|0 (CaQQLa)201-0020292
|
| 650 |
|
7 |
|a Aging
|2 fast
|0 (OCoLC)fst00800293
|
| 650 |
|
7 |
|a Aging
|x Molecular aspects
|2 fast
|0 (OCoLC)fst00800318
|
| 650 |
|
7 |
|a Stem cells
|2 fast
|0 (OCoLC)fst01132975
|
| 700 |
1 |
|
|a Nilsson, Susie,
|e editor.
|
| 776 |
0 |
8 |
|i Print version:
|t Stem cell niche during ageing.
|b First edition.
|d Cambridge, MA : Academic Press, 2020
|z 0128220198
|z 9780128220191
|w (OCoLC)1141024783
|
| 830 |
|
0 |
|a Advances in stem cells and their niches ;
|v volume 4.
|
| 856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/bookseries/24685097/4
|z Texto completo
|
