Wound healing, tissue repair, and regeneration in diabetes /

Wound Healing, Tissue Repair and Regeneration in Diabetes explores a wide range of topics related to wound healing, tissue repair and regeneration, putting a special focus on diabetes and obesity. The book addresses the molecular and cellular pathways involved in the process of wound repair and rege...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Bagchi, Debasis, Das, Amitava, Roy, Sashwati
Formato: Electrónico eBook
Idioma:Inglés
Publicado: [S.l.] : ELSEVIER ACADEMIC PRESS, 2020.
Temas:
Diabetes.
Wound healing.
Diabetes Mellitus
Wound Healing
Cicatrisation.
Diab�ete.
Diabetes
Wound healing
Acceso en línea:Texto completo
Tabla de Contenidos:
  • References
  • Chapter 2: Role of oxidants and antioxidants in diabetic wound healing
  • 1. Introduction
  • 2. Oxidative stress and wound healing
  • 3. Antioxidants and wound healing
  • 3.1. Examples of enzymatic antioxidants
  • 3.1.1. SOD, GSTs, GPx, NADPH
  • 3.1.2. Heme-oxygenase 1 (HO-1)
  • 3.1.3. Peroxiredoxins and thioredoxins
  • 3.2. Nonenzymatic antioxidants
  • 3.2.1. Vitamin C
  • 3.2.2. Vitamin E
  • 3.2.3. Vitamin D
  • 3.2.4. Alpha-lipoic acid (-LA) and its reduced form of dihydrolipoic acid (DHLA)
  • 3.2.5. N-acetyl-cysteine (NAC)
  • 3.3. Other small molecules
  • 3.4. Herbal extracts
  • Front Cover
  • Wound Healing, Tissue Repair, and Regeneration in Diabetes
  • Copyright
  • Dedication
  • Contents
  • Contributors
  • About the authors
  • Preface
  • Part 1: Background and overview
  • Chapter 1: The diabetic foot
  • 1. Introduction
  • 2. Clinical classification
  • 2.1. Definition
  • 2.2. Risk factors
  • 2.3. Etiology
  • 2.4. Epidemiology
  • 3. The complicated diabetic foot
  • 3.1. Vascular
  • 3.2. Neural
  • 3.3. Skin and soft tissue
  • 3.4. Bone
  • 3.5. Infection
  • 4. Care and management
  • 4.1. Treatment
  • 4.1.1. Other factors
  • 4.2. Prevention
  • 5. Conclusion
  • 3.4.1. Curcumin
  • 3.4.2. Honey
  • 3.5. Factor-E2-related factor (Nrf2)
  • 4. Diabetes, oxidative stress, and impaired/chronic wounds
  • 5. OS and the triggering of wound chronicity
  • 6. Conclusions
  • References
  • Further reading
  • Chapter 3: Chronic infection and inflammation: Hallmarks of diabetic foot ulcers
  • 1. Background
  • 2. Chronicity of wound infection
  • 2.1. Antibiotic resistance (ABR)
  • 2.2. Biofilm infection
  • 2.3. Novel approaches for therapeutics
  • 2.3.1. Electroceuticals
  • 2.3.2. Bacteriophage
  • 3. Dysregulated resolution of wound inflammation
  • 3.1. miRNA
  • 3.2. Macrophage function and phenotypes
  • 3.3. Efferocytosis
  • 4. Conclusion
  • References
  • Chapter 4: Diabetic peripheral neuropathy: An insight into the pathophysiology, diagnosis, and therapeutics
  • 1. Introduction
  • 2. Neuropathy
  • 2.1. Peripheral neuropathy
  • 2.2. Cranial neuropathy
  • 2.3. Autonomic neuropathy
  • 2.4. Focal neuropathy
  • 2.4.1. Mononeuropathy
  • 2.4.2. Polyneuropathy
  • 3. Experimental mouse models for DPN
  • 3.1. Diet-induced DPN mouse model
  • 3.2. Chemically induced DPN mouse model
  • 3.3. Genetically modified DPN mouse model
  • 4. Nociception assays
  • 4.1. Mechanical stimuli
  • 4.1.1. The manual von Frey test
  • 4.1.2. The electronic von Frey
  • 4.1.3. Randall-Selitto test
  • 4.2. Heat stimuli
  • 4.2.1. The tail-flick test
  • 4.2.2. Hot plate test
  • 4.2.3. Hargreaves test
  • 4.2.4. Thermal probe test
  • 4.3. Cold stimuli
  • 4.3.1. Cold plate test
  • 4.3.2. Acetone evaporation test
  • 4.3.3. Cold plantar assay
  • 4.3.4. Temperature preference test
  • 5. Nonstimulus evoked nociception
  • 5.1. Grimace scales
  • 5.2. Burrowing
  • 5.3. Weight-bearing and gait analysis
  • 5.4. Automated behavioral analysis

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