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200406s2020 ne o 000 0 eng d |
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|a YDX
|b eng
|e pn
|c YDX
|d OPELS
|d EBLCP
|d OCLCQ
|d OCLCF
|d CUS
|d UKMGB
|d DKU
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|a 019759680
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|a 1149188131
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|z 9780444642608
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|z (OCoLC)1149188131
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|a RC382
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|a 616.8/33
|2 23
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|a Recent advances in Parkinson's disease /
|c edited by Anders Bj�orklund, M. Angela Cenci.
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| 260 |
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|a Amsterdam :
|b Academic Press,
|c 2020.
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| 300 |
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|a 1 online resource
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a Progress in brain research ;
|v v. 252
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0 |
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|a Intro -- Recent Advances in Parkinson's Disease -- Copyright -- Contributors -- Contents -- Preface: The evolving scenario of Parkinson�s research -- Part I: Basic Science -- Chapter 1: What we can learn from iPSC-derived cellular models of Parkinson's disease -- 1. Introduction -- 2. Establishment of iPSC technology and methods of differentiation into DAns -- 2.1. Establishment of induced pluripotent stem cells -- 2.2. Differentiation into DAns -- 3. iPSC-derived neurons for disease modeling -- 3.1. Endoplasmic reticulum stress -- 3.2. Protein trafficking and degradation deficits
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| 505 |
8 |
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|a 3.3. Mitochondrial defects and oxidative stress -- 3.4. Alterations in calcium homeostasis -- 4. iPSC-derived glial cells for disease modeling -- 5. Co-culture systems, 3D cultures and organoids for disease modeling -- 6. iPSC-derived neurons for cell-based treatments -- 7. Limitations of iPSC-based models -- 8. Future applications -- 9. Conclusions -- Acknowledgments -- References -- Chapter 2: Animal models for preclinical Parkinson's research: An update and critical appraisal -- 1. Introduction -- 2. Models in different species -- 3. The importance of nigrostriatal dopaminergic degeneration
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| 505 |
8 |
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|a 4.3. Tertiary and quaternary structure of aSyn -- 4.4. The effect of PD-associated mutations in aSyn -- 4.5. Post-translational modifications -- 5. Alpha-synuclein pathology in the synapse -- 6. aSyn pathology in mitochondria -- 7. aSyn pathology in the ER-Golgi compartments -- 7.1. Degradation and clearance of aSyn -- 7.2. aSyn pathology and the cytoskeleton -- 7.3. Effects of aSyn in the nucleus -- 8. Spreading of aSyn pathology -- 9. The interplay between aSyn and the microbiome -- 10. Inflammation -- 11. Conclusions and outlook -- Acknowledgments -- References
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| 650 |
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0 |
|a Parkinson's disease.
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| 650 |
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2 |
|a Parkinson Disease
|0 (DNLM)D010300
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| 650 |
|
6 |
|a Maladie de Parkinson.
|0 (CaQQLa)201-0016037
|
| 650 |
|
7 |
|a Parkinson's disease.
|2 fast
|0 (OCoLC)fst01053693
|
| 655 |
|
4 |
|a Internet Resources.
|
| 655 |
|
4 |
|a Index not Present.
|
| 700 |
1 |
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|a Bj�orklund, Anders,
|d 1945-
|e editor.
|
| 700 |
1 |
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|a Cenci, M. Angela,
|e editor.
|
| 776 |
0 |
8 |
|i Print version:
|t Recent advances in Parkinson's disease.
|d Amsterdam : Academic Press, 2020
|z 0444642609
|z 9780444642608
|w (OCoLC)1111968015
|
| 830 |
|
0 |
|a Progress in brain research ;
|v v. 252.
|
| 856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/bookseries/00796123/252
|z Texto completo
|
