GPCR signaling in cancer /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Shukla, Arun K.
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Cambridge : Academic Press, 2020.
Colección:Advances in cancer research ; v. 145.
Temas:
Cancer > Molecular aspects.
G proteins.
GTP-Binding Proteins
Neoplasms
Cancer > Aspect mol�eculaire.
Prot�eines G.
Cancer > Molecular aspects
G proteins
Internet Resources.
Index not Present.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • GPCR Signaling in Cancer
  • Copyright
  • Contents
  • Contributors
  • Chapter One: Atypical chemokine receptors in tumor cell growth and metastasis
  • 1. Introduction
  • 2. Specific ACKRs
  • 2.1. ACKR1/DARC
  • 2.2. ACKR2/D6
  • 2.3. ACKR3/RDC1/CXCR7
  • 2.3.1. Normal tissue distribution of ACKR3
  • 2.3.2. ACKR3 expression in tumor tissues and cells
  • 2.3.3. Structure and function of ACKR3
  • 2.3.4. ACKR3 and mitogenic signaling
  • 2.3.5. ACKR3 as a regulator of tumor cell migration
  • 2.3.6. ACKR3 as a biomarker for tumor progression
  • 2.3.7. Inhibitors of ACKR3 activities
  • 2.4. ACKR4/CCRL1
  • 2.5. ACKR5/CCRL2
  • 2.6. ACKR6/PITPNM3/Nir1
  • Acknowledgment
  • References
  • Chapter Two: The G protein coupled receptor CCR5 in cancer
  • 1. Genetics of cysteine-cysteine chemokine receptor type (CCR5)
  • 2. CCR5 and biochemical signaling
  • 3. CCR5 antagonists retasked in cancer (Jiao et al., 2018)
  • 4. CCR5 induces the hallmarks of cancer
  • 4.1. Activating invasion and metastasis (Jiao et al., 2018
  • Velasco-Velazquez et al., 2012)
  • 4.2. Avoiding immune destruction-the anti-tumor immune response (Blattner et al., 2018
  • Hawila et al., 2017)
  • 4.3. Induction of proliferative signaling, angiogenesis (Ben-Baruch, 2012
  • Soria Ben-Baruch, 2008) and resistance to cell ...
  • 4.4. Deregulated cellular energetics and cancer stem cells
  • 5. Preclinical analysis of CCR5 inhibition in metastatic cancer
  • 6. Clinical studies
  • Acknowledgments
  • Conflict of interest
  • References
  • Chapter Three: Targeting G protein-coupled receptors in cancer therapy
  • 1. Introduction
  • 2. Domain-specific GPCR-targeted therapeutics
  • 3. GPCR extracellular domain-specific targeted therapy
  • 3.1. Chemokine receptors
  • 3.2. Protease-activated receptors
  • 3.3. Lysophosphatidic acid receptors
  • 3.4. Sphingosine-1-phosphate receptors
  • 4. The intracellular domain as an attractive therapeutic target
  • 5. Targeting the GPCR ICD and its signaling proteins
  • 6. Targeting GPCR-specific signal transduction intermediates
  • 7. GPCR-derived Hippo-YAP-TAZ signaling as a therapeutic target
  • 8. GPCR-derived Wnt signaling as a therapeutic target
  • 9. Future perspectives
  • Funding
  • Conflicts of interest
  • References
  • Chapter Four: The diverse and complex roles of atypical chemokine receptors in cancer: From molecular biology to clinical ...
  • 1. Introduction
  • 2. Molecular cell biology and physiological roles of ACKRs
  • 2.1. ACKR1
  • 2.2. ACKR2
  • 2.3. ACKR3
  • 2.4. ACKR4
  • 3. The roles of ACKRs in animal tumor models
  • 3.1. ACKRs in primary tumor growth and metastasis
  • 3.2. ACKRs in angiogenesis
  • 3.3. ACKRs in inflammation and tumor immunity
  • 3.4. Dual, tumor context-specific effects of ACKRs
  • 4. ACKR expression in patient samples and correlation with clinical outcome
  • 4.1. ACKR1 and ACKR2
  • 4.2. ACKR3
  • 4.3. ACKR4
  • 4.4. Co-expression of ACKR1, ACKR2 and ACKR4
  • 4.5. ACKRs predicting therapy response

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