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00000cam a2200000 a 4500 |
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SCIDIR_on1141666732 |
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OCoLC |
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20231120010438.0 |
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m o d |
| 007 |
cr |n||||||||| |
| 008 |
200224s2020 mau o 000 0 eng d |
| 040 |
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|a YDX
|b eng
|e pn
|c YDX
|d UIU
|d EBLCP
|d OPELS
|d UKAHL
|d OCLCQ
|d OHS
|d OCLCO
|d OCLCF
|d OCLCA
|d OCLCQ
|d OCLCO
|d OCLCQ
|d CASUM
|d OCLCO
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| 020 |
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|a 9780128202319
|q (electronic bk.)
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| 020 |
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|a 0128202319
|q (electronic bk.)
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| 020 |
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|z 9780128202302
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| 020 |
|
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|z 0128202300
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| 035 |
|
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|a (OCoLC)1141666732
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| 050 |
|
4 |
|a RC268.4
|
| 082 |
0 |
4 |
|a 616.99/4
|2 23
|
| 245 |
0 |
0 |
|a GPCR signaling in cancer /
|c edited by Arun K. Shukla.
|
| 260 |
|
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|a Cambridge :
|b Academic Press,
|c 2020.
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| 300 |
|
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|a 1 online resource
|
| 336 |
|
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|a text
|b txt
|2 rdacontent
|
| 337 |
|
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|a computer
|b c
|2 rdamedia
|
| 338 |
|
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a Advances in cancer research ;
|v v. 145
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| 505 |
0 |
|
|a Intro -- GPCR Signaling in Cancer -- Copyright -- Contents -- Contributors -- Chapter One: Atypical chemokine receptors in tumor cell growth and metastasis -- 1. Introduction -- 2. Specific ACKRs -- 2.1. ACKR1/DARC -- 2.2. ACKR2/D6 -- 2.3. ACKR3/RDC1/CXCR7 -- 2.3.1. Normal tissue distribution of ACKR3 -- 2.3.2. ACKR3 expression in tumor tissues and cells -- 2.3.3. Structure and function of ACKR3 -- 2.3.4. ACKR3 and mitogenic signaling -- 2.3.5. ACKR3 as a regulator of tumor cell migration -- 2.3.6. ACKR3 as a biomarker for tumor progression -- 2.3.7. Inhibitors of ACKR3 activities
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| 505 |
8 |
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|a 2.4. ACKR4/CCRL1 -- 2.5. ACKR5/CCRL2 -- 2.6. ACKR6/PITPNM3/Nir1 -- Acknowledgment -- References -- Chapter Two: The G protein coupled receptor CCR5 in cancer -- 1. Genetics of cysteine-cysteine chemokine receptor type (CCR5) -- 2. CCR5 and biochemical signaling -- 3. CCR5 antagonists retasked in cancer (Jiao et al., 2018) -- 4. CCR5 induces the hallmarks of cancer -- 4.1. Activating invasion and metastasis (Jiao et al., 2018 -- Velasco-Velazquez et al., 2012) -- 4.2. Avoiding immune destruction-the anti-tumor immune response (Blattner et al., 2018 -- Hawila et al., 2017)
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| 505 |
8 |
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|a 4.3. Induction of proliferative signaling, angiogenesis (Ben-Baruch, 2012 -- Soria Ben-Baruch, 2008) and resistance to cell ... -- 4.4. Deregulated cellular energetics and cancer stem cells -- 5. Preclinical analysis of CCR5 inhibition in metastatic cancer -- 6. Clinical studies -- Acknowledgments -- Conflict of interest -- References -- Chapter Three: Targeting G protein-coupled receptors in cancer therapy -- 1. Introduction -- 2. Domain-specific GPCR-targeted therapeutics -- 3. GPCR extracellular domain-specific targeted therapy -- 3.1. Chemokine receptors -- 3.2. Protease-activated receptors
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| 505 |
8 |
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|a 3.3. Lysophosphatidic acid receptors -- 3.4. Sphingosine-1-phosphate receptors -- 4. The intracellular domain as an attractive therapeutic target -- 5. Targeting the GPCR ICD and its signaling proteins -- 6. Targeting GPCR-specific signal transduction intermediates -- 7. GPCR-derived Hippo-YAP-TAZ signaling as a therapeutic target -- 8. GPCR-derived Wnt signaling as a therapeutic target -- 9. Future perspectives -- Funding -- Conflicts of interest -- References -- Chapter Four: The diverse and complex roles of atypical chemokine receptors in cancer: From molecular biology to clinical ...
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| 505 |
8 |
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|a 1. Introduction -- 2. Molecular cell biology and physiological roles of ACKRs -- 2.1. ACKR1 -- 2.2. ACKR2 -- 2.3. ACKR3 -- 2.4. ACKR4 -- 3. The roles of ACKRs in animal tumor models -- 3.1. ACKRs in primary tumor growth and metastasis -- 3.2. ACKRs in angiogenesis -- 3.3. ACKRs in inflammation and tumor immunity -- 3.4. Dual, tumor context-specific effects of ACKRs -- 4. ACKR expression in patient samples and correlation with clinical outcome -- 4.1. ACKR1 and ACKR2 -- 4.2. ACKR3 -- 4.3. ACKR4 -- 4.4. Co-expression of ACKR1, ACKR2 and ACKR4 -- 4.5. ACKRs predicting therapy response
|
| 650 |
|
0 |
|a Cancer
|x Molecular aspects.
|
| 650 |
|
0 |
|a G proteins.
|
| 650 |
|
2 |
|a GTP-Binding Proteins
|0 (DNLM)D019204
|
| 650 |
|
2 |
|a Neoplasms
|0 (DNLM)D009369
|
| 650 |
|
6 |
|a Cancer
|x Aspect mol�eculaire.
|0 (CaQQLa)201-0212614
|
| 650 |
|
6 |
|a Prot�eines G.
|0 (CaQQLa)201-0203891
|
| 650 |
|
7 |
|a Cancer
|x Molecular aspects
|2 fast
|0 (OCoLC)fst00845397
|
| 650 |
|
7 |
|a G proteins
|2 fast
|0 (OCoLC)fst00936830
|
| 655 |
|
4 |
|a Internet Resources.
|
| 655 |
|
4 |
|a Index not Present.
|
| 700 |
1 |
|
|a Shukla, Arun K.
|
| 776 |
0 |
8 |
|i Print version:
|z 0128202300
|z 9780128202302
|w (OCoLC)1109974816
|
| 830 |
|
0 |
|a Advances in cancer research ;
|v v. 145.
|
| 856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/bookseries/0065230X/145
|z Texto completo
|
