Aquaporin Regulation /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Litwack, Gerald
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Cambridge : Elsevier, 2020.
Colección:Vitamins and hormones ; v. 112.
Temas:
Aquaporins.
Aquaporins
Aquaporines.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Front Cover
  • Aquaporin Regulation
  • Copyright
  • Former Editors
  • Contents
  • Contributors
  • Preface
  • Chapter One: Perspectives on the evolution of aquaporin superfamily
  • 1. Introduction: Aquaporin (AQP) superfamily
  • 2. Classification of AQPS
  • 3. Distribution of AQP subfamilies
  • 3.1. Bacterial AQPs: Origin of AQPs
  • 3.2. Unicellular eukaryotic AQPs: Variable wAQPs/gAQPs ratios
  • 3.3. Fungal AQPs: Osmoregulatory AQPs
  • 3.4. Plant AQPs: Diversified wAQPs after losing gAQPs
  • 3.5. Invertebrate AQPs: Acquisition of sAQPs
  • 3.6. Tick and insect AQPs: Eventual loss of gAQPs
  • 3.7. Vertebrate AQPs: More wAQPs?
  • 4. Summary and perspectives
  • Acknowledgment
  • Conflict of interest
  • References
  • Chapter Two: Structure and dynamics of aquaporin-1
  • 1. Introduction
  • 2. Model and method
  • 3. Results and discussion
  • 4. Conclusions and outlook
  • Acknowledgments
  • References
  • Chapter Three: Selectivity and transport in aquaporins from molecular simulation studies
  • 1. Conformational dynamics and water transport
  • 2. Selectivity: Proton exclusion
  • 3. Selectivity: Permeation of other solutes
  • 4. Quantifying water permeability
  • 5. Interaction with lipids
  • 6. Response to electric field
  • 7. In silico drug design
  • 8. Future directions
  • Acknowledgments
  • References
  • Chapter Four: Aquaporin regulation in metabolic organs
  • 1. Aquaporins and nuclear receptors
  • 2. Aquaporins regulation in the adipose tissue
  • 3. Aquaporins in the digestive system
  • 3.1. Aquaporins in the liver
  • 3.2. Aquaporin in pancreas
  • 3.3. Aquaporins in stomach and intestine
  • 4. Aquaporins regulation in kidney
  • 5. Aquaporins in muscle
  • 6. Clinical relevance of AQPs
  • 7. Conclusions and future directions
  • References
  • Chapter Five: Phosphorylation of human AQP2 and its role in trafficking
  • 1. The role of AQP2 in regulating urine volume
  • 2. Trafficking of AQP2
  • 2.1. AQP2 trafficking is controlled by post-translational modifications
  • 3. AQP2 phosphorylation and its role in trafficking
  • 3.1. Protein kinases and phosphatases in AQP2 trafficking
  • 4. Phosphorylation-dependent protein-protein interactions in AQP2 trafficking
  • 4.1. Heat shock proteins
  • 4.2. Actin cytoskeleton
  • 4.3. Annexin II
  • 4.4. Myelin and lymphocyte associated protein (MAL)
  • 4.5. 14-3-3 proteins
  • 4.6. Lysosomal trafficking regulator interacting protein 5 (LIP5)
  • 5. Concluding remarks
  • References
  • Chapter Six: Regulation of aquaporin-2 by RNA interference
  • 1. General features of RNA interference
  • 1.1. RNA interference by small RNAs
  • 1.2. Post-transcriptional regulation by miRNAs in the kidney
  • 1.3. Post-transcriptional regulation of renal aquaporins mediated by miRNAs
  • 2. Identification of small RNA molecules
  • 2.1. Identification of small RNA molecule expression
  • 2.2. Identification of small RNA molecules-target mRNA interaction

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