Nanopharmaceuticals : expectations and realities of multifunctional drug delivery systems. Volume 1 /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Shegokar, Ranjita
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Amsterdam : Elsevier, 2020.
Temas:
Drug delivery systems.
Nanoparticles.
Drug Delivery Systems
Nanoparticles
Syst�emes d'administration de m�edicaments.
Nanoparticules.
Drug delivery systems
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Front Cover
  • NANOPHARMACEUTICALS
  • NANOPHARMACEUTICALS
  • Copyright
  • Contents
  • Contributors
  • Preface
  • 1
  • Solid lipid nanoparticles (SLN): prediction of toxicity, metabolism, fate and physicochemical properties
  • 1. Introduction
  • 2. Toxicity profiling
  • 3. Physicochemical properties
  • 3.1 Encapsulation parameters
  • 3.2 Particle size
  • 3.3 Zeta potential
  • 3.4 Particle morphology
  • 3.5 Differential scanning calorimetry
  • 3.6 Stability of formulations and release profile
  • 4. Administration routes and drug bioavailability
  • 4.1 Topical and dermal routes
  • 4.2 Ocular delivery
  • 4.3 Oral administration
  • 4.4 Parenteral administration
  • 4.5 Nasal and pulmonary delivery
  • 5. Conclusions
  • Abbreviations
  • Acknowledgments
  • References
  • 2
  • Role of nanocarriers and their surface modification in targeting delivery of bioactive compounds
  • 1. Bioactive compounds as promising therapeutic agents
  • 1.1 Curcuma sp
  • 1.2 Zingiber officinale
  • 1.3 Silybum marianum L
  • 1.4 Gnetum gnemon
  • 1.5 Physalis angulata
  • 2. Complexity of bioactive compounds
  • 3. Biological barriers
  • 3.1 Physical barriers
  • 3.2 Biochemical barriers
  • 4. Nanocarrier: a strategy to overcome biological barriers
  • 4.1 Lipid-based nanocarrier systems
  • 4.1.1 Liposomes
  • 4.1.2 Nanoemulsions
  • 4.1.3 Solid lipid nanoparticles
  • 5. Safe-by-design bioactive-loaded nanocarrier system development
  • 6. Cellular uptake capability of bioactive-loaded nanocarrier system
  • 7. Surface modification of nanocarriers
  • 8. Biokinetic profile of bioactive-loaded nanocarriers
  • 9. Challenges of bioactive-loaded nanocarrier to clinical translation
  • 9.1 Patents on herbal nanoparticles for breast cancer
  • 10. Conclusion
  • References
  • 3
  • Polymeric nanomicelles as versatile tool for multidrug delivery in chemotherapy
  • 1. Introduction
  • 2. Micelles, principles and characterization
  • 2.1 Preparation methods
  • 2.2 Characterization techniques
  • 2.3 Drug-loading methods
  • 3. Polymeric micelles for codelivery of chemotherapeutics
  • 3.1 Codelivery of chemotherapeutics to overcome multidrug resistance
  • 3.1.1 Codelivery of chemotherapeutics and chemosensitizers
  • 3.1.2 Codelivery of chemotherapeutics and downregulating gene agents
  • 3.2 Codelivery of chemotherapeutics to achieve synergistic effects by methods other than effects on MDR
  • 3.3 Codelivery of chemotherapeutics to mitigate side effects
  • 4. Stimuli-responsive codelivery of polymeric micelles
  • 4.1 pH-sensitive codelivery systems
  • 4.2 Redox-sensitive codelivery systems
  • 5. Targeted codelivery of polymeric micelles
  • 6. Application of polymeric micelles in codelivery for multiple therapies
  • 6.1 Chemo-immunotherapy
  • 6.2 Chemo-angiogenic therapy
  • 6.3 Chemo-photothermal therapy
  • 6.4 Chemo-radiotherapy
  • 6.5 Chemo-enzyme prodrug therapy

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