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Improving the therapeutic ratio in head and neck cancer /
Improving the Therapeutic Ratio in Head and Neck Cancer provides a complete review of current approaches to modulating therapeutic sensitivity in head and neck cancer. It presents a broad background of current approaches and by highlighting the potential for clinical translational, introduces a road...
| Clasificación: | Libro Electrónico |
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| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London, United Kingdom ; Cambridge, MA :
Academic Press, an imprint of Elsevier,
[2020]
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| Edición: | First edition. |
| Colección: | Cancer sensitizing agents for chemotherapy ;
v. 6. |
| Temas: | |
| Acceso en línea: | Texto completo |
| Sumario: | Improving the Therapeutic Ratio in Head and Neck Cancer provides a complete review of current approaches to modulating therapeutic sensitivity in head and neck cancer. It presents a broad background of current approaches and by highlighting the potential for clinical translational, introduces a roadmap for how to move promising preclinical findings into the clinic. The book discusses topics such as immunotherapy and molecularly targeted therapies in head and neck cancer, PI3k/mTOR pathway, autophagy inhibition to sensitize HNC to radiation and chemotherapy, TAM and Eph/Ephrin family proteins and metabolic reprogramming to modulate therapeutic sensitivity. Additionally, it details approaches to improve the response to immunotherapy, and Chk1/2 inhibition in radiation and cetuximab resistance. This book is a valuable source to head and neck cancer researchers and advanced students, and to those studying specific approaches in other model systems and disease sites. |
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| Notas: | Restoration of wild-type p53 confirmation and function in HNSCC as a novel therapeutic approach |
| Descripción Física: | 1 online resource (378 pages) |
| Bibliografía: | Includes bibliographical references and index. |
| ISBN: | 9780128178690 0128178698 |