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Cancer Stem Cells /
Cancer Stem Cells, Volume 141 in the Advances in Cancer Research series, presents the latest release in this ongoing, well-regarded serial that provides invaluable information on the exciting and fast-moving field of cancer research. Topics covered in this new release include SIX-EYA-DACH network co...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Cambridge, MA :
Academic Press,
2019.
|
| Edición: | First edition. |
| Colección: | Advances in cancer research ;
v. 141. |
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 245 | 0 | 0 | |a Cancer Stem Cells / |c edited by Curt I. Civin, Tami J. Kingsbury, Minjung Kim. |
| 250 | |a First edition. | ||
| 264 | 1 | |a Cambridge, MA : |b Academic Press, |c 2019. | |
| 300 | |a 1 online resource | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 490 | 1 | |a Advances in cancer research ; |v volume 141 | |
| 504 | |a Includes bibliographical references. | ||
| 588 | 0 | |a Online resource; title from PDF title page (EBSCO, viewed January 31, 2019). | |
| 505 | 0 | |a Front Cover; Cancer Stem Cells; Copyright; Contents; Contributors; Preface; References; Chapter One: Regulation of cancer stem cell properties by SIX1, a member of the PAX-SIX-EYA-DACH network; 1. Introduction; 2. Cancer stem cells (CSCs); 3. SIX1 and CSCs; 4. Sustained proliferative signaling; 5. Evading growth suppressors; 6. Enabling replicative immortality; 7. Resisting cell death; 8. Genome instability and mutation; 9. Deregulating cellular energetics; 10. Inducing angiogenesis; 11. Regulation of SIX1 expression; 12. SIX1 clinical significance; 13. EYA; 14. DACH; 15. Concluding remarks. | |
| 505 | 8 | |a AcknowledgmentsConflict of interest; References; Chapter Two: Dormancy and cancer stem cells: An enigma for cancer therapeutic targeting; 1. Introduction; 1.1. Classification of cancer stem cells and non-stem cancer cells based on dormancy; 1.2. Different forms of dormancy; 1.3. Dormancy, metastasis, CSCs, heterogeneity, plasticity and recurrence; 2. Molecular mechanisms of dormancy; 2.1. Effect of different niches on dormancy; 2.1.1. Bone marrow stem cell niche; 2.1.2. Perivascular niche; 2.1.3. CSC niche; 2.1.4. Metastatic niche; 2.2. Angiogenic switch; 2.3. Microenvironmental factors. | |
| 505 | 8 | |a 2.4. Epigenetics in dormancy2.5. Oncogene addiction; 2.6. Biophysical regulators of dormancy; 2.7. Biomarkers of tumor dormancy; 2.8. Senescence and dormancy; 2.9. Autophagy and dormancy; 3. Therapy and dormancy; 4. Expert opinion; Acknowledgments; Conflict of interest; References; Further reading; Chapter Three: Clonal hematopoiesis: Pre-cancer PLUS; 1. Introduction; 2. CH vs CHIP; 3. CHIP vs MDS; 4. CH from stochastic processes; 5. CH from selection; 5.1. Processes of aging; 5.2. Cytotoxic therapy; 5.3. Immune-mediated; 6. Evolution of evidence for CH in asymptomatic individuals. | |
| 505 | 8 | |a 7. Epidemiology of CH8. CH from candidate drivers; 9. CH from unknown drivers; 10. Germline predisposition to CH; 11. CH and hematologic malignancy; 12. CHIP and CVD risk; 13. CH in other conditions; 14. Conclusion; References; Chapter Four: Assays for functionally defined normal and malignant mammary stem cells; 1. Introduction; 2. Breast cancer stem cells: A unifying theory or an impossible hope?; 3. Evolution of functional normal and malignant stem cell assays; 4. Mammary repopulating unit cell assay to quantify normal mammary stem cells. | |
| 505 | 8 | |a 5. Mammary tumor initiating cell assay to measure breast cancer stem cells5.1. Important considerations; 6. DNA barcoding as a method to study clonal dynamics of normal and malignant mammary stem cells; 6.1. Factors affecting barcoding experiments; 6.1.1. Barcode design; 6.1.2. Barcode diversity; 6.1.3. Viral transduction; 6.1.4. Barcode analysis; 7. Conclusions; 8. Future perspectives; Acknowledgments; References; Chapter Five: Hypoxia-inducible factors promote breast cancer stem cell specification and maintenance in response to hypo ... ; 1. Introduction; 1.1. Breast cancer stem cells. | |
| 520 | |a Cancer Stem Cells, Volume 141 in the Advances in Cancer Research series, presents the latest release in this ongoing, well-regarded serial that provides invaluable information on the exciting and fast-moving field of cancer research. Topics covered in this new release include SIX-EYA-DACH network control of cancer stem cell properties, Dormancy and the cancer cell niche, Clonal hematopoiesis: A hematopoietic stem cell disorder of aging, Stringent assays to study human breast cancer stem cells, Regulation of breast cancer stem cell specification and maintenance by hypoxia-inducible factors, Cancer stem cells in breast and prostate: fact or fiction, and much more. | ||
| 650 | 0 | |a Cancer cells |x Growth |x Regulation. | |
| 650 | 0 | |a Cancer cells |x Differentiation. | |
| 650 | 0 | |a Stem cells. | |
| 650 | 2 | |a Neoplasms |0 (DNLM)D009369 | |
| 650 | 2 | |a Neoplastic Stem Cells |0 (DNLM)D014411 | |
| 650 | 2 | |a Stem Cells |0 (DNLM)D013234 | |
| 650 | 6 | |a Cellules canc�ereuses |x Croissance |x R�egulation. |0 (CaQQLa)201-0125133 | |
| 650 | 6 | |a Cellules souches. |0 (CaQQLa)201-0058821 | |
| 650 | 6 | |a Cellules souches tumorales. |0 (CaQQLa)000346679 | |
| 650 | 7 | |a HEALTH & FITNESS |x Diseases |x General. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Clinical Medicine. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Diseases. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Evidence-Based Medicine. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Internal Medicine. |2 bisacsh | |
| 650 | 7 | |a Cancer cells |x Differentiation |2 fast |0 (OCoLC)fst01905379 | |
| 650 | 7 | |a Cancer cells |x Growth |x Regulation |2 fast |0 (OCoLC)fst00845568 | |
| 650 | 7 | |a Stem cells |2 fast |0 (OCoLC)fst01132975 | |
| 655 | 4 | |a Internet Resources. | |
| 655 | 4 | |a Index not Present. | |
| 700 | 1 | |a Civin, Curt I., |e editor. | |
| 700 | 1 | |a Kingsbury, Tami J., |e editor. | |
| 700 | 1 | |a Kim, MinJung, |e editor. | |
| 700 | 1 | |a Fisher, Paul B., |e editor. | |
| 776 | 0 | 8 | |i Print version: |z 0128149949 |z 9780128149942 |w (OCoLC)1044853537 |
| 830 | 0 | |a Advances in cancer research ; |v v. 141. | |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/bookseries/0065230X/141 |z Texto completo |