Research in the biomedical sciences : transparent and reproducible /

Research in the Biomedical Sciences: Transparent and Reproducible documents the widespread concerns related to reproducibility in biomedical research and provides a best practices guide to effective and transparent hypothesis generation, experimental design, reagent standardization (including valida...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Williams, Michael (Editor ), Curtis, Michael J. (Editor ), Mullane, Kevin (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: London : Academic Press, [2018]
Temas:
Medical sciences > Research.
Biology > Research.
Biomedical Research
Sciences de la sant�e > Recherche.
Biologie > Recherche.
HEALTH & FITNESS > Diseases > General.
MEDICAL > Clinical Medicine.
MEDICAL > Diseases.
MEDICAL > Evidence-Based Medicine.
MEDICAL > Internal Medicine.
Biology > Research
Medical sciences > Research
Internet Resources.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Cover
  • Title Page
  • Copyright Page
  • Contents
  • List of Contributors
  • Preface
  • References
  • Chapter 1
  • Reproducibility in Biomedical Research
  • 1.1
  • Introduction
  • 1.2
  • Defining Reproducibility
  • 1.2.1
  • A New Lexicon for Reproducibility
  • 1.2.1.1
  • Methods Reproducibility
  • 1.2.1.2
  • Results Reproducibility
  • 1.2.1.3
  • Inferential Reproducibility
  • 1.2.1.4
  • Bayesian Paradigms in Reproducibility
  • 1.3
  • Discipline Specific Terminology in the Biomedical Sciences?
  • 1.4
  • Experimental Factors in Addition to Statistics That Affect Reproducibility1.4.1
  • Unknown Unknowns Affecting Reproducibility
  • 1.4.1.1
  • The Crabbe Mouse Study
  • 1.4.1.2
  • Reproducibility Confounds in RNA Interference
  • 1.4.1.3
  • Caenorhabditis Lifespan
  • 1.4.2
  • Known Unknowns: Tacit Expertize
  • 1.4.3
  • Diminishing Effects: Regression to the Mean
  • 1.4.4
  • Overinterpretation of Effects on Secondary Endpoints in Studies
  • 1.5
  • The Impact of the Internet on the Evolution of Research Practices�a#x80;#x94;Databases and Third Party Analyses
  • 1.5.1
  • Data Input
  • 1.5.2
  • Data Curation1.5.3
  • Cross-Database Integration
  • 1.5.4
  • Analytical Tools
  • 1.6
  • The Reproducibility Problem
  • 1.6.1
  • Factors Contributing to the Reproducibility Problem
  • 1.6.2
  • Human Contributions to the Reproducibility Problem
  • 1.6.2.1
  • Litigation in Basic Biomedical Research
  • 1.6.3
  • The Impact of the Internet on Publishing and Disseminating Information
  • 1.6.3.1
  • High and Low Profile Journals
  • 1.7
  • The Literature on Reproducibility in Biomedical Research
  • 1.7.1
  • An Age-Old Concern
  • 1.7.2
  • Concerns in the 21st Century
  • 1.7.3
  • Reproducibility in the 21st Century: Origins, Scope and Momentum1.7.3.1
  • Why Most Published Research Findings are False
  • 1.7.3.2
  • Believe it or not: How Much can we Rely on Published Data on Potential Drug Targets?
  • 1.7.3.3
  • Drug Development: Raise Standards for Preclinical Cancer Research
  • 1.7.3.4
  • Reproducibility: An Academic Viewpoint
  • 1.7.3.5
  • Reproducibility in the Psychological Sciences
  • 1.7.3.6
  • Researcher Awareness of Fraud
  • 1.8
  • Is There a Reproducibility Crisis?
  • 1.9
  • Trouble at the Laboratory?
  • 1.10
  • Retractions
  • 1.10.1
  • RetractionWatch1.10.2
  • Continued Citation of Retracted Publications
  • 1.10.3
  • The Spectrum of Irreproducibility
  • 1.10.4
  • Research Misconduct
  • 1.10.5
  • Fraud
  • 1.10.6
  • Notable Examples of Fraud�a#x80;#x94;Biomedical Researchers Behaving Badly
  • 1.10.6.1
  • MMR Vaccine: Andrew Wakefield�a#x80;#x94;Royal Free Hospital
  • 1.10.6.2
  • Embryonic Stem Cells: Hwang Woo-Suk�a#x80;#x94;Seoul National University
  • 1.10.6.3
  • Environment and Human Behavior: Diederik Stapel�a#x80;#x94;Tilburg University
  • ""1.10.6.4
  • Stimulus-Triggered Acquisition of Pluripotency (STAP): Haruko Obokata�a#x80;#x94;RIKEN Institute""

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