MiRNAs in Differentiation and Development /

'MiRNAs in Differentiation and Development', the latest in the 'International Review of Cell and Molecular Biology' series, reviews and details current advances in cell and molecular biology.

Bibliographic Details
Call Number:Libro Electrónico
Other Authors: Galluzzi, Lorenzo (Editor), Vitale, Ilio (Editor)
Format: Electronic eBook
Language:Inglés
Published: London : Academic Press, 2017.
Series:International review of cell and molecular biology ; v. 333.
Subjects:
MicroRNA.
MicroARN.
SCIENCE > Life Sciences > Biochemistry.
Online Access:Texto completo
Table of Contents:
  • Front Cover; MiRNAs in Differentiation and Development; Copyright; Contents; Contributors; Chapter One: MicroRNAs in DNA Damage Response, Carcinogenesis, and Chemoresistance; 1. Introduction; 2. MiRNA Regulation in Response to DNA Damage; 2.1. Transcriptional Regulation of MiRNAs; 2.2. Posttranscriptional Regulation of MiRNAs; 3. DNA Damage Response Regulation by MiRNAs; 3.1. Sensors of DNA Damage and Mediators of the DNA Damage Response; 3.2. Transducers of the DNA Damage Response; 3.3. Effectors of the DNA Damage Response; 3.3.1. Effectors of Apoptosis; 3.3.2. Effectors of the Cell Cycle
  • 3.3.3. Effectors of DNA Repair4. MiRNAs in Cancer; 4.1. MiRNAs as Oncogenes; 4.2. MiRNAs as Tumor Suppressors; 4.3. MiRNAs as Both Oncogenes and Tumor Suppressor Genes; 5. The Role of MiRNAs in Drug Resistance; 5.1. MiRNAs Regulate Drug Resistance Through Survival and/or Apoptosis Pathways; 5.2. MiRNAs Regulate Drug Resistance Through the Drug-Targeting and DNA-Repair Pathways; 5.3. MiRNAs Regulate Drug Resistance Through Regulating Drug Delivery and Drug Metabolism; 5.4. MiRNAs Regulate Drug Resistance in Pharmacogenomics; 6. Conclusion; References
  • Chapter Two: MicroRNAs as Key Effectors in the p53 Network1. Introduction; 2. MicroRNAs, Small Helpers With Big Effects in the p53 Pathway; 2.1. p53 Transcriptionally Upregulates MicroRNAs; 2.2. p53 Transcriptionally Downregulates a Subset of MicroRNAs; 2.3. p53 Modulates MicroRNA Maturation and mRNA Accessibility; 2.4. p53 Is a Direct Target of MicroRNAs; 2.5. p53 Is an Indirect Target of MicroRNAs; 3. MicroRNAs Engaged in Fulfilling GOF Activities of Mutant p53; 3.1. MicroRNAs Transcriptionally Regulated by Mutant p53
  • 3.2. Mutant p53 Regulates MicroRNA Biogenesis at Posttranscriptional Level4. Conclusions; Acknowledgments; References; Chapter Three: Impact of MicroRNAs in the Cellular Response to Hypoxia; 1. Introduction; 2. Regulation of MiRNA Expression by Hypoxia; 2.1. Control of hypoxamiRs Expression Through HIFs-Dependent Mechanisms; 2.1.1. MiR-210; 2.1.2. Other hypoxamiRs; 2.2. HIF-Independent Transcriptional Regulation of hypoxamiRs; 2.3. Epigenetic Mechanisms; 2.4. Regulation of MiRNA Biogenesis by Hypoxia; 2.5. MiRNA Export and Hypoxia
  • 3. The Diverse Roles of MiRNAs in Cellular Adaptation to Hypoxia3.1. The hypoxamiR Targetome: Present and Future; 3.2. Feedback Regulatory Loops Between MiRNAs and Hypoxia; 3.2.1. MiR-210; 3.2.2. Other hypoxamiRs; 3.3. Metabolic Adaptation; 3.3.1. MiR-210; 3.3.2. Other hypoxamiRs; 3.4. Cell Cycle; 3.4.1. MiR-210; 3.4.2. Other hypoxamiRs; 3.5. DNA Repair; 3.5.1. MiR-210; 3.5.2. Other hypoxamiRs; 3.6. Apoptosis; 3.6.1. MiR-210; 3.6.2. Other hypoxamiRs; 3.7. Angiogenesis; 3.7.1. MiR-210; 3.7.2. Other hypoxamiRs; 3.8. Inflammation and Immunity; 3.8.1. MiR-210; 3.8.2. Other hypoxamiRs

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