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Disease-modifying targets in neurodegenerative disorders : paving the way for disease-modifying therapies /
Disease-Modifying Targets in Neurodegenerative Disorders: Paving the Way for Disease-Modifying Therapies examines specific neurodegenerative disorders in comprehensive chapters written by experts in the respective fields. Each chapter contains a summary of the disease management field, subsequently...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London :
Academic Press,
[2017]
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Cover; Title Page; Copyright Page; Contents; List of Contributors; Chapter 1
- The multitude of therapeutic targets in neurodegenerative proteinopathies; Protein Misfolding and Aggregation; Mechanism of Assembly; Prion-Like Propagation of Protein Assemblies; Propagation Routes of Pathogenic Protein Aggregates; Limiting Steps in the Propagation of Pathogenic Protein Assemblies; Therapeutic Strategies Targeting the Physiological Levels of Aggregation-Prone Proteins Involved in Neurodegeneration.
- Therapeutic Strategies Targeting the Misfolding and Aggregation of Proteins Involved in NeurodegenerationTherapeutic Strategies Targeting the Accumulation of Misfolded Pathologic Protein Aggregates; Therapeutic Strategies Targeting the Cell-to-Cell Propagation of Pathogenic Protein Aggregates; Therapeutic Strategies Aimed at Restoring the Damage Pathogenic Protein Aggregates Induce; Therapeutic Strategies Targeting Misfolded Pathologic Protein Aggregate-Mediated Neuroinflammation; Limitations of the Different Therapeutic Strategies; Acknowledgments; References.
- Mechanisms of Neuroinflammation-Mediated NeurodegenerationAlzheimer's Disease; Parkinson's Disease; Amyotrophic Lateral Sclerosis; Huntington's Disease; Frontotemporal Dementia and Lewy Body Dementia; Therapeutic Strategies Targeting Neuroinflammation in Progressive Neurodegenerative Diseases; Future Perspectives; Conclusions; References; Chapter 4A
- Stem cells in neurodegeneration: mind the gap; Introduction; Part I: Stem Cells; Genome Editing of Stem Cells; The Generation of Specific Cell Types; Part II: Stem Cells as Regenerative Therapy; Clinical Translation and Immunology.