Biology and engineering of stem cell niches /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Vishwakarma, Ajaykumar (Editor ), Karp, Jeffrey (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: London, United Kingdom : Academic Press is an imprint of Elsevier, 2017.
Temas:
Stem cells.
Stem Cell Niche
Stem Cells
Cellules souches.
SCIENCE > Life Sciences > Cell Biology.
Stem cells
Electronic books.
Internet Resources.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Front Cover; BIOLOGY AND ENGINEERING OF STEM CELL NICHES; BIOLOGY AND ENGINEERING OF STEM CELL NICHES; Copyright; Contents; List of Contributors; Foreword; 1
  • Biology of Stem Cell Niches and Molecular Mechanisms; 1
  • The Need to Study, Mimic, and Target Stem Cell Niches; 1. INTRODUCTION; 1.1 The Stem Cell Niche in Health and Disease; 1.2 Components of Stem Cell Niche; 2. BIOLOGY OF THE STEM CELL NICHE; 2.1 Behavior of Stem Cells: Hierarchical Versus Stochastic Model; 2.2 Embryonic and Adult Stem Cell Niches; 3. BIOCHEMICAL AND BIOPHYSICAL REGULATION OF STEM CELL BEHAVIOR.
  • 3.1 Extracellular Matrix and Biochemical Cues3.2 Soluble Growth Factors and Ligands; 3.3 Physical Cues and Matrix Mechanics; 3.4 Oxygen and Metabolism; 3.5 Immune Cells, Inflammation, and Immunomodulation; 4. MIMICKING THE STEM CELL NICHE: BIOENGINEERING TOOLS AND TECHNIQUES; 5. BIOENGINEERING SPECIALIZED ARTIFICIAL STEM CELL NICHES FOR CLINICAL THERAPIES; References; 2
  • Harnessing the Biology of Stem Cells' Niche; 1. INTRODUCTION; 2. COMPONENTS OF THE STEM CELL NICHE; 2.1 Cellular Components; 2.2 Noncellular Components; 3. INTEGRATIVE NETWORKS REGULATING THE NICHE.
  • 4. DISTINCT NICHES FOR DIFFERENT STAGES OF DIFFERENTIATION5. NEOPLASTIC TRANSFORMATION AND DISTURBANCE OF THE TISSUE ECOSYSTEM; 6. CONCLUSION; ABBREVIATIONS AND ACRONYMS; Glossary; References; 3
  • Pluripotent Stem Cell Microenvironment; 1. INTRODUCTION; 2. PLURIPOTENT CELL MICROENVIRONMENT IN THE EARLY MAMMALIAN EMBRYO; 2.1 Lineage Specification in the Preimplantation Embryo; 2.2 Role of Extraembryonic Cells in Development of the Pluripotent Cells; 2.2.1 Interactions Between Inner and Outer Blastomeres During the ICM Versus TE Specification and Associated Signals.
  • 2.2.2 Cellular Interplay Between the PrE and the Epiblast3. MICROENVIRONMENT OF PLURIPOTENT STEM CELLS IN VITRO; 3.1 Derivation of Embryonic Stem Cells; 3.2 Cellular Heterogeneity in Mouse ESC Cultures; 3.3 Epigenetic Mechanisms Underlying Metastable States of Mouse ESCs; 3.4 Heterogeneity of Human ESC Culture; 3.5 Functional and Epigenetic Distinctions Between Human ESC Subfractions; 3.6 Regulatory Niche in Human ESC Culture; 4. CONCLUSION; ABBREVIATIONS AND ACRONYMS; Glossary; Acknowledgment; References; 4
  • Regulation of Hematopoietic Stem Cell Dynamics by Molecular Niche Signaling.

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