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020 |a 9780128037454  |q (electronic bk.) 
020 |a 0128037458  |q (electronic bk.) 
020 |z 9780128037249  |q (print) 
020 |z 0128037245 
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050 4 |a QP625.A27 
060 4 |a 2017 E-455 
060 4 |a QU 58 
072 7 |a SCI  |x 007000  |2 bisacsh 
082 0 4 |a 572/.475  |2 23 
245 0 0 |a Adenosine receptors in neurodegenerative diseases /  |c edited by David Blum, Lu�isa V. Lopes. 
264 1 |a London, United Kingdom :  |b Academic Press is an imprint of Elsevier,  |c 2017. 
300 |a 1 online resource 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
500 |a Includes index. 
588 0 |a Online resource; title from PDF title page (ScienceDirect, viewed March 22, 2017). 
505 0 |a Front Cover; Adenosine Receptors in Neurodegenerative Diseases; Copyright Page; Dedication; Contents; List of Contributors; Foreword and History of Adenosine in the Central Nervous System; References; Acknowledgments; I. Physiology; 1 Adenosine Receptor Biology in the Central Nervous System; Sources of Adenosine in the CNS; Receptor Subtypes and Their CNS Distribution; A1 Adenosine Receptors; A2A Adenosine Receptors; A2B Adenosine Receptors; A3 Adenosine Receptors; Crosstalk With Other Receptors; Adenosine and CNS Diseases; Recent Clinical Trials; A1 Adenosine Receptors. 
505 8 |a A2A Adenosine ReceptorsA2B Adenosine Receptors; A3 Adenosine Receptors; References; 2 Adenosine Signaling Throughout Development; Introduction; Effects of Adenosine Signaling and Its Dysfunction in CNS; Effects of Adenosine in Oligodendrocytes Development; Effects of Adenosine on Cardiovascular System During Embryogenesis; Postnatal Effects of Adenosine on Cardiovascular System; Postnatal Effect of Adenosine on Respiratory System; Use of Methylxanthines in Premature Babies; Postnatal Effects of Adenosine on the Genitourinary System; Postnatal Effect of Adenosine on the Enteric System. 
505 8 |a Postnatal Effect of Adenosine on Other SystemsConclusion; References; 3 Influence of Adenosine on Synaptic Excitability; Introduction; Molecular & Physiological Mechanisms; Influence on Neurotransmitter Availability and Basal Synaptic Transmission; Adenosine Tunes the Responses of Postsynaptic Glutamate and GABA Receptors; Astrocyte-Derived Adenosine Controls Basal Synaptic Transmission and the Available Range for Plasticity Control; Metamodulation by Adenosine: Impact on Synaptic Plasticity; Adenosine Shapes Synapses for Plasticity; Implications for Epilepsy; Pathophysiological Mechanisms. 
505 8 |a Adenosine Receptor-Dependent EffectsAdenosine Receptor-Independent Effects; Disruption of Adenosine Homeostasis in Epilepsy; Comorbidities of Epilepsy; Therapeutic Implications; Conclusions and Outlook; Acknowledgments; References; 4 Regulation of Synaptic Transmission by Adenosine at the Neuromuscular Junction; Introduction; Neuromuscular Junction; Structural Organization of the Neuromuscular Junction; Neuromuscular Transmission; Coexistence of Transmitters and Neuromodulators; Adenosine as a Neuromodulator at the Neuromuscular Junction. 
505 8 |a Pathways: Synthesis and Degradation of Adenosine at the Neuromuscular JunctionAdenosine Receptors; Nerve Terminals; Schwann Cells; Adenosine Receptors and Their Interactions With Other Receptors at the Neuromuscular Junction; Crosstalk Between A1 and A2A Receptors; Crosstalk Between Adenosine Receptors and Acetylcholine Receptors; Adenosine Receptors and BDNF Actions; Adenosine Signaling in Ageing and Disease; Conclusions; References; 5 Gene Regulation of Adenosine A2A Receptors in the Central Nervous System; General Introduction; A2AR Promoter and Gene Structure; Epigenetics of ADORA2A. 
504 |a Includes bibliographical references and index. 
650 0 |a Adenosine  |x Receptors. 
650 0 |a Nervous system  |x Degeneration  |x Molecular aspects. 
650 0 |a Adenosine. 
650 1 2 |a Receptors, Purinergic P1  |0 (DNLM)D018047 
650 2 2 |a Adenosine  |0 (DNLM)D000241 
650 2 2 |a Neurodegenerative Diseases  |0 (DNLM)D019636 
650 2 2 |a Receptor, Adenosine A2A  |0 (DNLM)D043705 
650 6 |a Ad�enosine  |0 (CaQQLa)201-0007623  |x R�ecepteurs.  |0 (CaQQLa)201-0375415 
650 6 |a Ad�enosine.  |0 (CaQQLa)201-0007623 
650 7 |a SCIENCE  |x Life Sciences  |x Biochemistry.  |2 bisacsh 
650 7 |a Adenosine  |2 fast  |0 (OCoLC)fst00796563 
650 7 |a Adenosine  |x Receptors  |2 fast  |0 (OCoLC)fst00796565 
650 7 |a Nervous system  |x Degeneration  |x Molecular aspects  |2 fast  |0 (OCoLC)fst01036094 
655 0 |a Computer network resources. 
655 4 |a Fulltext. 
655 4 |a Internet Resources. 
700 1 |a Blum, David,  |e editor. 
700 1 |a Lopes, Lu�isa V.,  |e editor. 
776 0 8 |i Print version:  |t Adenosine receptors in neurodegenerative diseases.  |d London, United Kingdom : Academic Press is an imprint of Elsevier, 2017  |z 0128037245  |z 9780128037249  |w (OCoLC)959872849 
856 4 0 |u https://sciencedirect.uam.elogim.com/science/book/9780128037249  |z Texto completo