Cancer stem cells : targeting the roots of cancer, seeds of metastasis, and sources of therapy resistance /

This book introduces the basic concepts and advanced understanding of cancer stem cells, covering general overviews, organ-specific identifications, and their characteristic mechanisms. It also explores innovative therapeutic strategies in pre-clinical and clinical trials to target cancer stem cells...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Liu, Huiping
Otros Autores: Lathia, Justin Durla
Formato: Electrónico eBook
Idioma:Inglés
Publicado: [London] : Academic Press is an imprint of Elsevier, 2016.
Temas:
Cancer cells.
Stem cells.
Stem Cells
Cellules canc�ereuses.
Cellules souches.
HEALTH & FITNESS > Diseases > General.
MEDICAL > Clinical Medicine.
MEDICAL > Diseases.
MEDICAL > Evidence-Based Medicine.
MEDICAL > Internal Medicine.
Cancer cells
Stem cells
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Front Cover; Cancer Stem Cells; Cancer Stem Cells; Copyright; Dedication; Contents; List of Contributors; Foreword by Jane Visvader; Foreword by Stanton L. Gerson; Preface; Acknowledgments; I
  • CSC Overview and Methodology; 1
  • Introduction: Cancer Stem Cells; INTRODUCTION; CANCER STEM CELL ORIGINS; Cancer Stem Cell Generation From a Single Cell of Origin; Two Models for Tumor Growth and Expansion; IDENTIFICATION OF THE CANCER STEM CELL POPULATION; Features of Cancer Stem Cell; Biomarkers for Cancer Stem Cell Identification; Key Signaling Pathways Involved in Cancer Stem Cell Maintenance.
  • MOUSE MODELS OF CANCER STEM CELL FUNCTIONPatient-Derived Xenograft Models; Germline Genetically Engineered Mouse Models; Somatic Genetically Engineered Mouse Models; Germline-Derived Allograft Models; Humanized Mouse Models; STRATEGIES FOR TARGETING CANCER STEM CELL; Protective Signaling Pathways; Immunotherapies Against Cell Surface Markers; Tumor Microenvironment-The Complicit Cells of the Cancer Stem Cell Niche; ATP-Binding Cassette Transporters: Multidrug and Redox Stress Resistance; FUTURE OF CANCER STEM CELL-DIRECTED THERAPIES; CONCLUSION; LIST OF ACRONYMS AND ABBREVIATIONS; References.
  • Reporter Systems Used for Enrichment and Analysis of Cancer Stem CellsSOX2; NANOG; OCT4; SORE6; NOTCH; TERT; s-SHIP; Alpha Fetoprotein; Transcription Factor/Lymphoid Enhancer Binding Factor; REX-1; Caveats of Using Reporters; Enrichment for Cancer Stem Cells Using Culture Media; Surface Markers Used for Enrichment and Analysis of Cancer Stem Cells; Acute Myelogenous Leukemia; Acute Lymphoblastic Leukemia; Chronic Myelogenous Leukemia; Breast Cancer; Colorectal Cancer; Liver Cancer; Pancreatic Cancer; Glioblastoma; Lung Cancer; Prostate Cancer; FUNCTIONAL ANALYSIS; Lineage Tracing.
  • In Vivo Lineage TracingGenetic Marking Methods in Transgenic Mouse Models; Lineage Tracing of Cancer Stem Cells In Vivo; Skin Papilloma; Intestinal Polyp; Medulloblastoma; Glioblastoma; Potential Utility of Genetic Marking Based on the Zygosity State; Lineage Tracing in Human Tumor Samples; In Vitro and In Vivo Tumor Formation and Clonogenic Assays; The Utility of Time-Lapse Video Microscopy for Cancer Stem Cell Studies; CONCLUSION AND FUTURE DIRECTIONS; List of Acronyms and Abbreviations; Acknowledgment; References; II
  • CSCs in Representative Organ Systems.
  • 4
  • Critical Updates to the Leukemia Stem Cell Model.

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