Nonsense mutation correction in human diseases : an approach for targeted medicine /

Nonsense Mutation Correction in Human Diseases: An Approach for Targeted Medicine provides an introduction on genetic diseases, discusses the prevalence of nonsense mutations, the consequences of a nonsense mutation for the expression of the mutant gene, and the presentation of the nonsense-mediated...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autores principales: Benhabiles, Hana (Autor), Jia, Jieshuang (Autor), Lejeune, Fabrice (Autor)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: London : Acedemic Press is an imprint of Elsevier, [2016]
Temas:
Genetic disorders.
Mutation (Biology)
Targeted Gene Repair
Genetic Diseases, Inborn
Mutation
Codon, Nonsense
Nonsense Mediated mRNA Decay
Maladies g�en�etiques.
Mutation (Biologie)
HEALTH & FITNESS > Diseases > General.
MEDICAL > Clinical Medicine.
MEDICAL > Diseases.
MEDICAL > Evidence-Based Medicine.
MEDICAL > Internal Medicine.
Genetic disorders
Acceso en línea:Texto completo
Descripción
Sumario:Nonsense Mutation Correction in Human Diseases: An Approach for Targeted Medicine provides an introduction on genetic diseases, discusses the prevalence of nonsense mutations, the consequences of a nonsense mutation for the expression of the mutant gene, and the presentation of the nonsense-mediated mRNA decay (NMD). It presents the mechanism of action and rationale associated with each strategy to correct nonsense mutations with the results of clinical trials to further support this basis. In addition, the book shows how it may be possible to combine several of these strategies to ultimately improve the efficiency of correction, also suggesting the future goals and objectives to improve treatment modalities in this evolving sphere of personalized medicine.
Descripción Física:1 online resource (ix, 180 pages)
Bibliografía:Includes bibliographical references and index.
ISBN:9780128044698
0128044691

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