Genes, environment and Alzheimer's disease /

This volume explores the interplay between genetic and environmental risk factors in the induction of cognitive decline and the development of dementia-related diseases such as Alzheimer's.

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Lazarov, Orly (Editor ), Tesco, Giuseppina (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: London, UK : Academic Press is an imprint of Elsevier, 2016.
Temas:
Alzheimer's disease.
Alzheimer's disease > Molecular aspects.
Alzheimer's disease > Genetic aspects.
Alzheimer Disease
Maladie d'Alzheimer.
Maladie d'Alzheimer > Aspect mol�eculaire.
Maladie d'Alzheimer > Aspect g�en�etique.
HEALTH & FITNESS > Diseases > General.
MEDICAL > Clinical Medicine.
MEDICAL > Diseases.
MEDICAL > Evidence-Based Medicine.
MEDICAL > Internal Medicine.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Front Cover; Genes, Environment and Alzheimer's Disease; Copyright Page; Contents; List of Contributors; Foreword; Preface; Introduction; 1 Molecular Mechanisms of Learning and Memory; From Plato's Wax Tablet to Genes; Memory Processes; Brain Structures Underlying Memory Processes; Cellular Basis of Memory; The Role of CREB in Memory; Pathways Activating CREB; HDACs/HATs Role in Gene Transcription; References; 2 When Cognitive Decline Becomes Pathology: From Normal Aging to Alzheimer's Disease; Models of Cognitive Decline in Healthy Aging
  • Distinguishing AD-Associated Cognitive Decline from Normal AgingDistinguishing Preclinical AD from Normal Aging with Event-Related Potentials (ERPs); Memory Deficits in Preclinical AD; Deficits in Associative Memory; Deficits in Pattern Separation; Deficits in Recollection and Familiarity; Deficits in Prospective Memory; Deficits in Remote Memory; Deficits in Working Memory; Asymmetric Cognitive Decline in Preclinical AD; Summary and Conclusions; References; 3 Adult Neurogenesis and Cognitive Function: Relevance for Disorders Associated with Human Aging; Introduction
  • Identification and Characterization of Adult NeurogenesisDevelopment and Maturation of Adult-Born Neurons; Adult Mammalian Hippocampal Circuitry; Factors Affecting Adult Neurogenesis; Neurogenic Niche; Stress; Aging; Environmental Enrichment, Physical Activity, and Diet; Antidepressants and Mood-Stabilizing Treatments; Proposed Functions of Adult Neurogenesis; Pattern Separation; Other Aspects of Spatial and Contextual Memory; Regulation of Mood and the HPA-Axis; Neurogenesis, Hippocampal Dysfunction, and Alzheimer's Disease; Proteins Linked to FAD Regulate Neurogenesis

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