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Genes, environment and Alzheimer's disease /
This volume explores the interplay between genetic and environmental risk factors in the induction of cognitive decline and the development of dementia-related diseases such as Alzheimer's.
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London, UK :
Academic Press is an imprint of Elsevier,
2016.
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| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 020 | |a 0128028858 |q (electronic bk.) | ||
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| 082 | 0 | 4 | |a 616.8/31 |2 23 |
| 245 | 0 | 0 | |a Genes, environment and Alzheimer's disease / |c edited by Orly Lazarov, Giuseppina Tesco. |
| 264 | 1 | |a London, UK : |b Academic Press is an imprint of Elsevier, |c 2016. | |
| 300 | |a 1 online resource | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 500 | |a Includes index. | ||
| 588 | 0 | |a Online resource; title from PDF title page (ScienceDirect, viewed March 9, 2016). | |
| 504 | |a Includes bibliographical references at the end of each chapters and index. | ||
| 505 | 0 | |a Front Cover; Genes, Environment and Alzheimer's Disease; Copyright Page; Contents; List of Contributors; Foreword; Preface; Introduction; 1 Molecular Mechanisms of Learning and Memory; From Plato's Wax Tablet to Genes; Memory Processes; Brain Structures Underlying Memory Processes; Cellular Basis of Memory; The Role of CREB in Memory; Pathways Activating CREB; HDACs/HATs Role in Gene Transcription; References; 2 When Cognitive Decline Becomes Pathology: From Normal Aging to Alzheimer's Disease; Models of Cognitive Decline in Healthy Aging | |
| 505 | 8 | |a Distinguishing AD-Associated Cognitive Decline from Normal AgingDistinguishing Preclinical AD from Normal Aging with Event-Related Potentials (ERPs); Memory Deficits in Preclinical AD; Deficits in Associative Memory; Deficits in Pattern Separation; Deficits in Recollection and Familiarity; Deficits in Prospective Memory; Deficits in Remote Memory; Deficits in Working Memory; Asymmetric Cognitive Decline in Preclinical AD; Summary and Conclusions; References; 3 Adult Neurogenesis and Cognitive Function: Relevance for Disorders Associated with Human Aging; Introduction | |
| 505 | 8 | |a Identification and Characterization of Adult NeurogenesisDevelopment and Maturation of Adult-Born Neurons; Adult Mammalian Hippocampal Circuitry; Factors Affecting Adult Neurogenesis; Neurogenic Niche; Stress; Aging; Environmental Enrichment, Physical Activity, and Diet; Antidepressants and Mood-Stabilizing Treatments; Proposed Functions of Adult Neurogenesis; Pattern Separation; Other Aspects of Spatial and Contextual Memory; Regulation of Mood and the HPA-Axis; Neurogenesis, Hippocampal Dysfunction, and Alzheimer's Disease; Proteins Linked to FAD Regulate Neurogenesis | |
| 520 | |a This volume explores the interplay between genetic and environmental risk factors in the induction of cognitive decline and the development of dementia-related diseases such as Alzheimer's. | ||
| 650 | 0 | |a Alzheimer's disease. | |
| 650 | 0 | |a Alzheimer's disease |x Molecular aspects. | |
| 650 | 0 | |a Alzheimer's disease |x Genetic aspects. | |
| 650 | 2 | |a Alzheimer Disease |0 (DNLM)D000544 | |
| 650 | 6 | |a Maladie d'Alzheimer. |0 (CaQQLa)201-0114128 | |
| 650 | 6 | |a Maladie d'Alzheimer |0 (CaQQLa)201-0114128 |x Aspect mol�eculaire. |0 (CaQQLa)201-0374959 | |
| 650 | 6 | |a Maladie d'Alzheimer |0 (CaQQLa)201-0114128 |x Aspect g�en�etique. |0 (CaQQLa)201-0377534 | |
| 650 | 7 | |a HEALTH & FITNESS |x Diseases |x General. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Clinical Medicine. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Diseases. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Evidence-Based Medicine. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Internal Medicine. |2 bisacsh | |
| 650 | 7 | |a Alzheimer's disease. |2 fast |0 (OCoLC)fst00806532 | |
| 650 | 7 | |a Alzheimer's disease |x Genetic aspects. |2 fast |0 (OCoLC)fst00806543 | |
| 650 | 7 | |a Alzheimer's disease |x Molecular aspects. |2 fast |0 (OCoLC)fst00806550 | |
| 700 | 1 | |a Lazarov, Orly, |e editor. | |
| 700 | 1 | |a Tesco, Giuseppina, |e editor. | |
| 776 | 0 | 8 | |i Print version: |t Genes, environment and Alzheimer's disease. |d Amsterdam, [Netherlands] : Academic Press, �2016 |h 425 pages |z 9780128028513 |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780128028513 |z Texto completo |
| 880 | 8 | |6 505-00/(S |a Methodologies for Studying Adult NeurogenesisLabeling Dividing and Maturing Cells; Manipulating Neurogenesis in Rodents; Human Technologies; Conclusion; References; I. Hallmarks and Genetic Forms of AD; 4 The Amyloid β Precursor Protein and Cognitive Function in Alzheimer's Disease; Introduction; The APP Gene and Its Homologs; The APP Protein, Its Domains, and Its Proteolytic Fragments; Intracellular Trafficking and Processing of APP; Cholesterol and APP Processing; APP-Interacting Proteins: Signal Transduction and Processing; Interactors with the YENPTY Motif | |
| 880 | 8 | |6 505-00/(S |a Low-Density Lipoprotein ReceptorsFunctions of APP; Neurogenesis: Embryonic and Adult; Neurite Outgrowth; Axonal Transport; Synaptic Formation and Function; Transcription Factor; Metal Binding/Redox; Does Aβ Have a Function?; APP Knockout Mice; APP and AD; Disrupted Axonal Transport; Disrupted Neurogenesis; Altered APP Processing/Translocation; Altered Signal Transduction; References; 5 Molecular Pathways in Alzheimer's Disease and Cognitive Function: New Insights into Pathobiology of Tau; Introduction; Normal Production and Function of Tau; Pathogenic Tau; Tau-Mediated Neuronal Deficits | |