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Ion channels as therapeutic targets. Part A /
This volume is the second part of�i�A�the thematic on Ion Channels as Therapeutic Targets. The popular Advances in Protein Chemistry and Structural Biology series, an essential resource for protein chemists, �i�A�brings forth new information about protocols and analysis of proteins, with each themat...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Cambridge, MA :
Academic Press is an imprint of Elsevier,
2016.
|
| Colección: | Advances in protein chemistry and structural biology ;
v. 103. |
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 245 | 0 | 0 | |a Ion channels as therapeutic targets. |n Part A / |c edited by Rossen Donev. |
| 264 | 1 | |a Cambridge, MA : |b Academic Press is an imprint of Elsevier, |c 2016. | |
| 300 | |a 1 online resource | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 490 | 1 | |a Advances in protein chemistry and structural biology ; |v volume 103 | |
| 500 | |a Includes indexes. | ||
| 588 | 0 | |a Online resource; title from PDF title page (ScienceDirect, viewed March 3, 2016). | |
| 520 | |a This volume is the second part of�i�A�the thematic on Ion Channels as Therapeutic Targets. The popular Advances in Protein Chemistry and Structural Biology series, an essential resource for protein chemists, �i�A�brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics. | ||
| 505 | 0 | |a Front Cover; Ion Channels as Therapeutic Targets, Part A; Copyright; Contents; Contributors; Preface; Chapter One: Proteostasis Maintenance of Cys-Loop Receptors; 1. Introduction; 2. Folding, Assembly, and Degradation of Cys-Loop Receptors in the ER; 2.1. Folding and Assembly of Cys-Loop Receptors; 2.2. ERAD of the Cys-Loop Receptors; 3. Trafficking of Cys-Loop Receptors from ER to Golgi and to Plasma Membrane; 4. Protein Quality Control of Cys-Loop Receptors on the Plasma Membrane; 4.1. Clustering; 4.2. Endocytosis; 5. Other Regulations of Cys-Loop Receptors | |
| 505 | 8 | |a 5.1. Lipid Involvement in Trafficking and Clustering5.2. Phosphorylation Signaling in the Biogenesis of the Receptors; 6. Disease and Therapy; References; Chapter Two: Harnessing the Flow of Excitation: TRP, Voltage-Gated Na+, and Voltage-Gated Ca2+ Channels in Contemporary M ... ; 1. Introduction; 1.1. Place of TRP, Nav, and Cav Channels in the Flow of Excitation in Neural Circuits; 2. TRP Channels; 2.1. Structure and Structural Varieties-Subfamilies of TRP Channels; 2.2. Regulation and Activation Mechanisms; 2.3. Therapeutic Potential of TRP Channels; 3. Voltage-Gated Na+ Channels | |
| 505 | 8 | |a 3.1. Structure3.2. Inactivation of Nav Channels; 3.3. Isoforms and Expression; 3.4. Regulation of Nav Channels; 3.5. Nav Channels as Therapeutic Targets; 3.5.1. Local Anesthetics; 3.5.2. Nav Blockers as Antiarrhythmic and Antianginal Drugs; 3.5.3. Nav Blockers in Neurological Disordes; 4. Voltage-Gated Ca2+ Channels; 4.1. Structure and Function; 4.2. Varieties and Expression; 4.2.1. Cav1 Channels; 4.2.2. Cav2 Channels; 4.2.3. Cav3 Channels; 4.3. Regulation; 4.4. Calcium Channels in Pharmacological Therapy; 4.4.1. L-Type Channel Blockers; 4.4.2. Blockers and Modulators of Cav2 Channels | |
| 505 | 8 | |6 880-01 |a 5.5. Considerations on the Treatment of Channelopathies6. Harnessing the Flow of Excitation in Neural Circuits; 7. Conclusion and Perspectives; Acknowledgments; References; Chapter Three: Ion Channels in Neurological Disorders; 1. Introduction; 1.1. Intricacy of Ion Channels in Membrane Physiology; 1.2. Role of Ion Channels in the Brain Homeostasis; 1.3. Impact of Channels on Blood-Brain Barrier; 1.4. How Channels Affect Gap Junctions, Release of Ions, and Homeostasis?; 1.5. What Are the Different Channels That Cause Ion Disturbance in Neurological Disorders?; 2. Aberrant Channels in NDDs | |
| 504 | |a Includes bibliographical references and indexes. | ||
| 650 | 0 | |a Ion channels. | |
| 650 | 2 | |a Ion Channels |0 (DNLM)D007473 | |
| 650 | 6 | |a Canaux ioniques. |0 (CaQQLa)201-0145111 | |
| 650 | 7 | |a SCIENCE |x Life Sciences |x Anatomy & Physiology. |2 bisacsh | |
| 650 | 7 | |a Ion channels |2 fast |0 (OCoLC)fst00978573 | |
| 700 | 1 | |a Donev, Rossen, |e editor. | |
| 776 | 0 | 8 | |i Print version: |a Donev, Rossen. |t Ion Channels as Therapeutic Targets, Part A. |d : Elsevier Science, �2016 |z 9780128047941 |
| 830 | 0 | |a Advances in protein chemistry and structural biology ; |v v. 103. | |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780128047941 |z Texto completo |
| 880 | 8 | |6 505-01/(S |a 4.4.3. Nonspecific Cav Channel Inhibitors5. Channelopathies of TRP, Nav, and Cav Channels; 5.1. TRP Channelopathies; 5.2. Channelopathies of Voltage-Gated Na+ Channels; 5.2.1. Nav1.1; 5.2.2. Nav1.2; 5.2.3. Nav1.4; 5.2.4. Nav1.5; 5.2.5. Nav1.6; 5.2.6. Nav1.7; 5.2.7. Nav1.8; 5.2.8. Nav1.9; 5.2.9. Nav β Subunit Channelopathies; 5.3. Channelopathies of Voltage-Gated Ca2+ Channels; 5.3.1. Cav1.1; 5.3.2. Cav1.2; 5.3.3. Cav1.3; 5.3.4. Cav1.4; 5.3.5. Cav2.1; 5.3.6. Cav3 Channels; 5.3.7. Cav Ancillary Subunit Channelopathies; 5.4. Acquired Channelopathies | |