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Vitamin D Hormone /
First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is rel...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Cambridge, MA :
Academic Press is an Imprint of Elsevier,
2016.
|
| Edición: | First edition. |
| Colección: | Vitamins and hormones ;
v. 100. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
MARC
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| 245 | 0 | 0 | |a Vitamin D Hormone / |c series editor, Gerald Litwack. |
| 250 | |a First edition. | ||
| 264 | 1 | |a Cambridge, MA : |b Academic Press is an Imprint of Elsevier, |c 2016. | |
| 300 | |a 1 online resource (xviii, 483 pages : |b color illustrations | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 490 | 1 | |a Vitamins and hormones ; |v volume 100 | |
| 546 | |a Text in English. | ||
| 588 | 0 | |a Online resource; title from PDF title page (EBSCO, viewed February 9, 2016). | |
| 520 | |a First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones. A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed. This volume focuses on vitamin D hormone. | ||
| 505 | 0 | |a Front Cover; Vitamin D Hormone; Copyright; Former Editors; Contents; Contributors; Preface; Chapter One: Vitamin D: Historical Overview; 1. The Discovery of Vitamin D; 2. The Discovery of the Physiological Functions of Vitamin D; 3. The Discovery of the Hormonal Form of Vitamin D; 4. The Isolation of the Final Active Form of Vitamin D; 5. Discovery of the Vitamin D Endocrine System (Fig. 5); 6. Other Metabolism of Vitamin D; 7. Discovery of the Vitamin D Receptor; References; Chapter Two: Genomic Determinants of Vitamin D-Regulated Gene Expression; 1. Introduction. | |
| 505 | 8 | |a 2. Genome-Wide Analysis Reveals New Concepts in Vitamin D Action3. Novel Principles of Vitamin D Action; 3.1. Modes of DNA Binding and Implications for the Regulatory Activity of the VDR; 3.1.1. Ligand-Independent Function of the VDR in the Hair Cycle; 3.1.2. Ligand-Independent Suppression of Gene Expression by the VDR; 3.2. 1,25(OH)2D3 Regulates Transcription via Multiple Enhancers Located at Sites Distal to Gene Promoters; 3.2.1. Defining Gene Regulation from Distal Sites; 3.2.2. Confirming Enhancer Function at Target Genes. | |
| 505 | 8 | |a 3.2.3. Application of the CRISPR/Cas9 Method to the Study of Gene Regulation4. The Influence of Cellular Differentiation on Vitamin D Activity; 4.1. Differentiation Is Accompanied by Direct Alterations in the VDR Cistrome; 4.2. The Impact of Osteoblast Differentiation on Master Regulatory Factor Distribution, Histone Modifying Activity, and R ... ; 4.3. Identification and Structure of the Osteoblast Enhancer Complex; 5. VDR Modulates Histone Acetylation at Target Genes; 6. Summary; Acknowledgments; References; Chapter Three: Inhibitors for the Vitamin D Receptor-Coregulator Interaction. | |
| 505 | 8 | |a 1. Introduction1.1. VDR Coactivators; 1.2. VDR Corepressors; 2. Peptide-Based Inhibitors of the VDR-Coregulator Interaction; 3. Small-Molecule Inhibitors of the VDR-Coregulator Interaction; 4. VDR Antagonists or Allosteric Inhibition of the VDR-Coregulators Interaction; 4.1. TEI-9647; 4.2. ZK159222; 4.3. ZK168281; 4.4. ZK191784; 4.5. Amide-Based VDR Antagonists; 4.6. Adamantane-Based VDR Antagonists; 4.7. Branched VDR Antagonists; 5. Conclusion and Future Directions; Acknowledgments; References; Chapter Four: Structural Studies of Vitamin D Nuclear Receptor Ligand-Binding Properties. | |
| 505 | 8 | |a 1. Introduction2. Crystal Structures of VDR LBD in Complex with 1,25(OH)2D3; 2.1. Overall Organization of Human, Rat, and Zebrafish VDR-LBD Complexes; 2.2. Activation Function-2; 2.3. Recognition of Coactivator Peptide; 2.4. VDR Ligand-Binding Pocket; 3. Secosteroidal Derivatives of 1,25(OH)2D3; 3.1. Superagonists of VDR; 3.1.1. 20-Epi Derivatives; 3.1.2. C2-Substituted Analogs; 3.1.3. 14-Epi Analogs; 3.2. Synthetic Compounds Expanding the VDR LBP; 3.2.1. Gemini Analogs; 3.2.2. 22-Alkyl Derivatives; 3.2.3. Adamantyl-Containing Compounds; 4. Synthetic Mimics of 1,25(OH)2D3. | |
| 650 | 0 | |a Vitamin D. | |
| 650 | 0 | |a Parathyroid hormone. | |
| 650 | 2 | |a Vitamin D |0 (DNLM)D014807 | |
| 650 | 2 | |a Parathyroid Hormone |0 (DNLM)D010281 | |
| 650 | 6 | |a Vitamine D. |0 (CaQQLa)201-0059246 | |
| 650 | 6 | |a Parathormone. |0 (CaQQLa)201-0090840 | |
| 650 | 7 | |a MEDICAL |x Physiology. |2 bisacsh | |
| 650 | 7 | |a SCIENCE |x Life Sciences |x Human Anatomy & Physiology. |2 bisacsh | |
| 650 | 7 | |a Parathyroid hormone |2 fast |0 (OCoLC)fst01053221 | |
| 650 | 7 | |a Vitamin D |2 fast |0 (OCoLC)fst01168206 | |
| 700 | 1 | |a Litwack, Gerald, |e editor. | |
| 776 | 0 | 8 | |i Print version: |a Litwack, Gerald. |t Vitamin D Hormone. |d : Elsevier Science, �2016 |z 9780128048245 |
| 830 | 0 | |a Vitamins and hormones ; |v v. 100. | |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780128048245 |z Texto completo |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/bookseries/00836729/100 |z Texto completo |