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Trafficking of GPCRs /
G protein-coupled receptors (GPCRs) constitute the largest superfamily of cell surface receptors that regulate a variety of cell functions. Over the past few decades great progress has been made in defining the roles of intracellular trafficking in controlling the functionality of the receptors as w...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Waltham, MA :
Academic Press,
2015.
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| Colección: | Progress in molecular biology and translational science ;
volume 132. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Trafficking of GPCRs; Copyright; Contents; Contributors; Preface; Chapter 1: Arrestins: Critical Players in Trafficking of Many GPCRs*; 1. Arrestins and GPCR Trafficking; 2. Non-visual Arrestins Mediate GPCR Internalization via Coated Pits; 3. Visual Arrestins and Trafficking Proteins; 4. Ubiquitination and Deubiquitination in GPCR Cycling and Signaling; 5. Faster Cycling Prevents Receptor Downregulation; 6. Arrestins in Receptor Recycling and Vesicle Trafficking: Questions Without Answers; 7. Conclusions and Future Directions; References.
- Chapter 2: Regulation of GPCR Trafficking by Ubiquitin1. Introduction; 2. Ubiquitination Machinery; 3. Mechanisms of GPCR Ubiquitination; 4. GPCR Regulation by E3 Ubiquitin Ligases; 5. Role of Ubiquitin in GPCR Internalization; 6. Role of Ubiquitin in GPCR Endosome to Lysosome Sorting; 7. Role of Deubiquitination in GPCR Lysosomal Sorting; 8. Effect of Biased Agonism on GPCR Trafficking: Role of Ubiquitin; 9. Conclusion; Acknowledgments; References; Chapter 3: Rhodopsin Trafficking and Mistrafficking: Signals, Molecular Components, and Mechanisms; 1. Introduction.
- 2. Trafficking Signals of Rhodopsin3. Molecular Components and Mechanisms for Specific OS Targeting of Rhodopsin; 3.1. Biogenesis of Rhodopsin in Endoplasmic Reticulum and Subsequent Maturation in Golgi Apparatus; 3.2. Sorting of Rhodopsin at the Golgi Apparatus and Post-Golgi Trafficking; 3.3. Vectorial Targeting of Rhodopsin from Golgi to the Connecting Cilium: Possible Involvement of Microtubules; 3.4. Trafficking of Rhodopsin Toward the Distal End of the Connecting Cilium; 3.5. Trafficking of Rhodopsin Within the OS; 4. Mislocalization of Rhodopsin Mutants.
- 4.1. Mislocalization Due to Defects of Trafficking Signals4.2. Mislocalization Due to Misfolding; 4.3. Mislocalization Due to Aberrant Arrestin Binding; 5. Future Perspectives; Acknowledgment; References; Chapter 4: Intracellular Trafficking of Neuropeptide Y Receptors; 1. Introduction: The Neuropeptide Y Receptor Family; 2. Evolution of the NPY Receptor Family; 3. Intracellular Trafficking of Y Receptors; 3.1. Anterograde Transport of Y Receptors; 3.2. Internalization of Y Receptors; 3.2.1. Chimeric Receptors; 3.2.2. N-Terminal Sequences; 3.2.3. C-Terminal Sequences; 3.2.4. Sequences in ICLs.
- 3.2.5. Arrestin Binding3.3. Recycling of Y Receptors; 4. Modulation of Internalization by Ligand Modification; 5. Conclusions; References; Chapter 5: Insights into Serotonin Receptor Trafficking: Cell Membrane Targeting and Internalization; 1. Introduction; 2. Trafficking of the 5-HT1R; 2.1. The 5-HT1A Receptor; 2.1.1. 5-HT1AR Desensitization upon SSRI Treatment In Vivo; 2.1.2. 5-HT1AR Internalization in Cell Lines; 2.1.3. 5-HT1AR Internalization in Neuronal Cultures; 2.2. 5-HT1AR Addressing; 2.2.1. 5-HT1AR and 5-HT1BR Addressing in Polarized Cell Lines.