Cargando…
Trafficking of GPCRs /
G protein-coupled receptors (GPCRs) constitute the largest superfamily of cell surface receptors that regulate a variety of cell functions. Over the past few decades great progress has been made in defining the roles of intracellular trafficking in controlling the functionality of the receptors as w...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Waltham, MA :
Academic Press,
2015.
|
| Colección: | Progress in molecular biology and translational science ;
volume 132. |
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
| LEADER | 00000cam a2200000Ii 4500 | ||
|---|---|---|---|
| 001 | SCIDIR_ocn910877988 | ||
| 003 | OCoLC | ||
| 005 | 20231120112003.0 | ||
| 006 | m o d | ||
| 007 | cr cnu|||unuuu | ||
| 008 | 150609s2015 mau ob 001 0 eng d | ||
| 040 | |a N$T |b eng |e rda |e pn |c N$T |d OPELS |d N$T |d IDEBK |d EBLCP |d DEBSZ |d UIU |d YDXCP |d OCLCF |d UAB |d OCLCQ |d D6H |d OCLCQ |d AU@ |d OCLCQ |d OCLCO |d OCLCQ |d OCLCO | ||
| 019 | |a 910969505 |a 931603982 | ||
| 020 | |a 9780128029558 |q electronic bk. | ||
| 020 | |a 0128029552 |q electronic bk. | ||
| 020 | |z 9780128029398 | ||
| 035 | |a (OCoLC)910877988 |z (OCoLC)910969505 |z (OCoLC)931603982 | ||
| 050 | 4 | |a QP552.G16 | |
| 072 | 7 | |a SCI |x 007000 |2 bisacsh | |
| 082 | 0 | 4 | |a 572/.69 |2 23 |
| 245 | 0 | 0 | |a Trafficking of GPCRs / |c edited by Guangyu Wu. |
| 264 | 1 | |a Waltham, MA : |b Academic Press, |c 2015. | |
| 264 | 4 | |c �2015 | |
| 300 | |a 1 online resource. | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 490 | 1 | |a Progress in molecular biology and translational science ; |v volume 132 | |
| 588 | 0 | |a Online resource; title from title details screen (ScienceDirect, viewed June 11, 2015). | |
| 504 | |a Includes bibliographical references and index. | ||
| 505 | 0 | |a Front Cover; Trafficking of GPCRs; Copyright; Contents; Contributors; Preface; Chapter 1: Arrestins: Critical Players in Trafficking of Many GPCRs*; 1. Arrestins and GPCR Trafficking; 2. Non-visual Arrestins Mediate GPCR Internalization via Coated Pits; 3. Visual Arrestins and Trafficking Proteins; 4. Ubiquitination and Deubiquitination in GPCR Cycling and Signaling; 5. Faster Cycling Prevents Receptor Downregulation; 6. Arrestins in Receptor Recycling and Vesicle Trafficking: Questions Without Answers; 7. Conclusions and Future Directions; References. | |
| 505 | 8 | |a Chapter 2: Regulation of GPCR Trafficking by Ubiquitin1. Introduction; 2. Ubiquitination Machinery; 3. Mechanisms of GPCR Ubiquitination; 4. GPCR Regulation by E3 Ubiquitin Ligases; 5. Role of Ubiquitin in GPCR Internalization; 6. Role of Ubiquitin in GPCR Endosome to Lysosome Sorting; 7. Role of Deubiquitination in GPCR Lysosomal Sorting; 8. Effect of Biased Agonism on GPCR Trafficking: Role of Ubiquitin; 9. Conclusion; Acknowledgments; References; Chapter 3: Rhodopsin Trafficking and Mistrafficking: Signals, Molecular Components, and Mechanisms; 1. Introduction. | |
| 505 | 8 | |a 2. Trafficking Signals of Rhodopsin3. Molecular Components and Mechanisms for Specific OS Targeting of Rhodopsin; 3.1. Biogenesis of Rhodopsin in Endoplasmic Reticulum and Subsequent Maturation in Golgi Apparatus; 3.2. Sorting of Rhodopsin at the Golgi Apparatus and Post-Golgi Trafficking; 3.3. Vectorial Targeting of Rhodopsin from Golgi to the Connecting Cilium: Possible Involvement of Microtubules; 3.4. Trafficking of Rhodopsin Toward the Distal End of the Connecting Cilium; 3.5. Trafficking of Rhodopsin Within the OS; 4. Mislocalization of Rhodopsin Mutants. | |
| 505 | 8 | |a 4.1. Mislocalization Due to Defects of Trafficking Signals4.2. Mislocalization Due to Misfolding; 4.3. Mislocalization Due to Aberrant Arrestin Binding; 5. Future Perspectives; Acknowledgment; References; Chapter 4: Intracellular Trafficking of Neuropeptide Y Receptors; 1. Introduction: The Neuropeptide Y Receptor Family; 2. Evolution of the NPY Receptor Family; 3. Intracellular Trafficking of Y Receptors; 3.1. Anterograde Transport of Y Receptors; 3.2. Internalization of Y Receptors; 3.2.1. Chimeric Receptors; 3.2.2. N-Terminal Sequences; 3.2.3. C-Terminal Sequences; 3.2.4. Sequences in ICLs. | |
| 505 | 8 | |a 3.2.5. Arrestin Binding3.3. Recycling of Y Receptors; 4. Modulation of Internalization by Ligand Modification; 5. Conclusions; References; Chapter 5: Insights into Serotonin Receptor Trafficking: Cell Membrane Targeting and Internalization; 1. Introduction; 2. Trafficking of the 5-HT1R; 2.1. The 5-HT1A Receptor; 2.1.1. 5-HT1AR Desensitization upon SSRI Treatment In Vivo; 2.1.2. 5-HT1AR Internalization in Cell Lines; 2.1.3. 5-HT1AR Internalization in Neuronal Cultures; 2.2. 5-HT1AR Addressing; 2.2.1. 5-HT1AR and 5-HT1BR Addressing in Polarized Cell Lines. | |
| 520 | |a G protein-coupled receptors (GPCRs) constitute the largest superfamily of cell surface receptors that regulate a variety of cell functions. Over the past few decades great progress has been made in defining the roles of intracellular trafficking in controlling the functionality of the receptors as well as in the development of various human diseases. This volume of Progress in Molecular Biology and Translational Science reviews the recent understanding of GPCR trafficking regulators and molecular mechanisms. Written by future leaders in the pain fieldCovers a wide range of targetsContains pr. | ||
| 650 | 0 | |a G proteins |x Receptors. | |
| 650 | 6 | |a Prot�eines G |0 (CaQQLa)201-0203891 |x R�ecepteurs. |0 (CaQQLa)201-0375415 | |
| 650 | 7 | |a SCIENCE / Life Sciences / Biochemistry |2 bisacsh | |
| 650 | 7 | |a G proteins |x Receptors |2 fast |0 (OCoLC)fst00936832 | |
| 700 | 1 | |a Wu, Guangyu, |e editor. | |
| 830 | 0 | |a Progress in molecular biology and translational science ; |v volume 132. | |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780128029398 |z Texto completo |