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SCIDIR_ocn900011699 |
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OCoLC |
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20231120111925.0 |
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|a 9780128008218
|q (electronic bk.)
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|a 0128008210
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|z 9780128007495
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|a (OCoLC)900011699
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|a QP572.C53
|b H86 2015
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|a 612.405
|2 23
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|a Human chorionic gonadotropin (hCG) /
|c Laurence A. Cole, Stephen A. Butler.
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250 |
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|a Second edition.
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264 |
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1 |
|a Amsterdam, Netherlands :
|b Elsevier,
|c 2015.
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300 |
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|a 1 online resource (xxxi, 414 pages) :
|b illustrations
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336 |
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
|2 rdacarrier
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|a Includes bibliographical references.
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|a Online resource; title from digital title page (viewed on January 9, 2015).
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|6 880-01
|a Front Cover; Human Chorionic Gonadotropin (hCG); Copyright Page; Contents; List of Contributors; About the Editors; Laurence A. Cole, PhD; Stephen A. Butler, PhD; Preface; References; Abbreviations; List of Tables; List of Figures; A. Introduction; 1 The expanding world of hCG; References; 2 History and introduction to human chorionic gonadotropin, a group of five independent growth factors; 2.1 History; 2.2 The pregnancy test; 2.3 Introduction to hCG; References; B. Synthesis, Structure and Function; 3 The molecular genetics of hCG; 3.1 The LH/hCG gene cluster.
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|6 880-02
|a 11.5 Degradation with pregnancy advancement11.6 Degradation in cancer; References; D. Biological Function: Pregnancy; 12 Pregnancy-1, functions during preimplantation and during blastocyst implantation; 12.1 Preimplantation; 12.2 Hyperglycosylated hCG function; 12.3 Blastocyst implantation; 12.4 Hyperglycosylated hCG the human time bomb; References; 13 Pregnancy-2, maintenance of gestation; References; 14 Pregnancy-3, creation and continuation of hemochorial placentation; References; 15 Paradigm shift on the targets of hCG actions; 15.1 Summary and perspectives; References.
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|a Human chorionic gonadotropin (hCG) is produced during pregnancy by the embryo. It promotes progesterone production by corpus luteal cells. It also functions in pregnancy to promote angiogenesis in uterine vasculature, it immuno-blands the invading placental tissue so it is not rejected by the maternal uterine tissues, promotes the growth of the uterus in line with the growth of the fetus, promotes the differentiation of growing cytotrophoblast cells, promotes the quiescence of contractions in the uterine myometrium during the course of pregnancy, and also has function in growth and developmen.
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|a Chorionic gonadotropins.
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1 |
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|a Chorionic Gonadotropin
|0 (DNLM)D006063
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650 |
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|a Gonadotrophine chorionique.
|0 (CaQQLa)201-0107246
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|a MEDICAL
|x Physiology.
|2 bisacsh
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650 |
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7 |
|a SCIENCE
|x Life Sciences
|x Human Anatomy & Physiology.
|2 bisacsh
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650 |
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7 |
|a Chorionic gonadotropins
|2 fast
|0 (OCoLC)fst00858623
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700 |
1 |
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|a Cole, Laurence A.,
|e editor,
|e author.
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700 |
1 |
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|a Butler, Stephen A.
|q (Stephen Andrew),
|e editor,
|e author.
|
776 |
0 |
8 |
|i Print version:
|a Cole, Laurence A.
|t Human chorionic gonadotropin.
|b Second edition
|z 9780128007495
|w (OCoLC)896856602
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856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/book/9780128007495
|z Texto completo
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880 |
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|6 505-00/(S
|a 3.2 Control of hCG gene expression: hCGα3.3 Control of hCG gene expression: hCGβ; 3.4 Summary; References; 4 Structure, synthesis, and secretion of hCG and hyperglycosylated hCG; 4.1 Amino acid sequence of hCG; 4.2 Carbohydrate structure of hCG; 4.3 hCG primary structure; 4.4 hCG secondary structure; 4.5 hCG tertiary structure; 4.6 hCG quaternary structure; 4.7 Combination of hCG subunits; 4.8 Synthesis and secretion of hCG; References; 5 Three-dimensional structures of hCG and hyperglycosylated hCG; 5.1 X-ray crystallography; 5.2 Refining this model; References.
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|6 505-01/(S
|a 6 Structures of hCG free α-subunit and free β-subunit6.1 Free α-subunit; 6.2 Free β-subunit; References; 7 Glycobiology of hCG; 7.1 Characteristic features of the sugar chains of glycoproteins; 7.2 Biosynthetic pathways of sugar chains of glycoproteins to form characteristic features; 7.3 The hCG sugar chains from urine of pregnant women and placenta; 7.4 Characteristic features of the sugar chains of free α-subunit; 7.5 Comparative studies of the N-linked sugar chains of hCG; 7.6 Alteration induced in the O-linked sugar chains of hCG by malignant transformation of trophoblasts.
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|6 505-02/(S
|a 7.7 Altered expression of GnT-IV in choriocarcinoma cells7.8 Glycosylated hCG as a diagnostic marker of trophoblastic diseases; 7.9 Functional role of the hCG sialic acid residues; 7.10 Future prospects; References; 8 Detecting hCG and hCG variants using MALDI-ToF-MS; References; 9 The hCG/LH hormone receptor; References; 10 TGFβ-II autocrine receptor; References; C. Continuous Dissociation and Degradation; 11 Degradation products of hCG, hyperglycosylated hCG, and free β-subunit; 11.1 Pure hCG preparations; 11.2 Nicking and enzyme cleavage; 11.3 Dissociation; 11.4 Liver clearance.
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